ENSG00000076356


Homo sapiens

Features
Gene ID: ENSG00000076356
  
Biological name :PLXNA2
  
Synonyms : O75051 / plexin A2 / PLXNA2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q32.2
Gene start: 208022242
Gene end: 208244320
  
Corresponding Affymetrix probe sets: 207290_at (Human Genome U133 Plus 2.0 Array)   213030_s_at (Human Genome U133 Plus 2.0 Array)   227032_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000356000
NCBI entrez gene - 5362     See in Manteia.
OMIM - 601054
RefSeq - XM_005273165
RefSeq - NM_025179
RefSeq - XM_005273164
RefSeq Peptide - NP_079455
swissprot - O75051
Ensembl - ENSG00000076356
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plxna2ENSDARG00000060372Danio rerio
 PLXNA2ENSGALG00000001264Gallus gallus
 P70207ENSMUSG00000026640Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PLXNA4 / Q9HCM2 / plexin A4ENSG0000022186667
PLXNA1 / Q9UIW2 / plexin A1ENSG0000011455464
P51805 / PLXNA3 / plexin A3ENSG0000013082759
O43157 / PLXNB1 / plexin B1ENSG0000016405035
PLXNB3 / Q9ULL4 / plexin B3ENSG0000019875333
O15031 / PLXNB2 / plexin B2ENSG0000019657631
PLXND1 / Q9Y4D7 / plexin D1ENSG0000000439931
O60486 / PLXNC1 / plexin C1ENSG0000013604022


Protein motifs (from Interpro)
Interpro ID Name
 IPR001627  Sema domain
 IPR002165  Plexin repeat
 IPR002909  IPT domain
 IPR008936  Rho GTPase activation protein
 IPR013548  Plexin, cytoplasmic RasGAP domain
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016201  PSI domain
 IPR031148  Plexin family
 IPR036352  Sema domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001756 somitogenesis IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0021785 branchiomotor neuron axon guidance IBA
 biological_processGO:0021915 neural tube development IEA
 biological_processGO:0021935 cerebellar granule cell precursor tangential migration IEA
 biological_processGO:0030334 regulation of cell migration IEA
 biological_processGO:0048841 regulation of axon extension involved in axon guidance IBA
 biological_processGO:0051642 centrosome localization IEA
 biological_processGO:0060037 pharyngeal system development IEA
 biological_processGO:0060174 limb bud formation IEA
 biological_processGO:0071526 semaphorin-plexin signaling pathway ISS
 cellular_componentGO:0002116 semaphorin receptor complex TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017154 semaphorin receptor activity ISS
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Sema3A PAK dependent Axon repulsion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
CRMPs in Sema3A signaling
Other semaphorin interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000010810 FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase  / complex
 ENSG00000082701 GSK3B / P49841 / glycogen synthase kinase 3 beta  / reaction
 ENSG00000077264 PAK3 / O75914 / p21 (RAC1) activated kinase 3  / reaction / complex
 ENSG00000075213 Q14563 / SEMA3A / semaphorin 3A  / complex / reaction
 ENSG00000006607 FARP2 / O94887 / FERM, ARH/RhoGEF and pleckstrin domain protein 2  / complex / reaction
 ENSG00000099250 NRP1 / O14786 / neuropilin 1  / complex / reaction
 ENSG00000176749 CDK5R1 / Q15078 / cyclin dependent kinase 5 regulatory subunit 1  / reaction / complex
 ENSG00000149269 PAK1 / Q13153 / p21 (RAC1) activated kinase 1  / reaction / complex
 ENSG00000172602 RND1 / Q92730 / Rho family GTPase 1  / reaction / complex
 ENSG00000164885 CDK5 / Q00535 / cyclin dependent kinase 5  / complex / reaction
 ENSG00000182511 FES / P07332 / FES proto-oncogene, tyrosine kinase  / complex / reaction
 ENSG00000180370 PAK2 / Q13177 / p21 (RAC1) activated kinase 2  / reaction / complex
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / complex / reaction
 ENSG00000092421 Q9H2E6 / SEMA6A / semaphorin 6A  / reaction / complex
 ENSG00000126458 RRAS / P10301 / RAS related  / reaction






 

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