ENSG00000092421


Homo sapiens

Features
Gene ID: ENSG00000092421
  
Biological name :SEMA6A
  
Synonyms : Q9H2E6 / SEMA6A / semaphorin 6A
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: q23.1
Gene start: 116443616
Gene end: 116574934
  
Corresponding Affymetrix probe sets: 1558338_at (Human Genome U133 Plus 2.0 Array)   215028_at (Human Genome U133 Plus 2.0 Array)   220454_s_at (Human Genome U133 Plus 2.0 Array)   223449_at (Human Genome U133 Plus 2.0 Array)   225660_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000345512
Ensembl peptide - ENSP00000425553
Ensembl peptide - ENSP00000425364
Ensembl peptide - ENSP00000424388
Ensembl peptide - ENSP00000422997
Ensembl peptide - ENSP00000422275
Ensembl peptide - ENSP00000421935
Ensembl peptide - ENSP00000257414
NCBI entrez gene - 57556     See in Manteia.
OMIM - 605885
RefSeq - XM_017009676
RefSeq - NM_001300780
RefSeq - NM_020796
RefSeq - XM_005272042
RefSeq - XM_006714663
RefSeq - XM_017009675
RefSeq Peptide - NP_065847
RefSeq Peptide - NP_001287709
swissprot - D6RAG9
swissprot - B3KU01
swissprot - A0A0A0MQU6
swissprot - D6RCR0
swissprot - Q9H2E6
swissprot - H0Y8V9
swissprot - E9PDV9
Ensembl - ENSG00000092421
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SEMA6AENSGALG00000002294Gallus gallus
 O35464ENSMUSG00000019647Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8NFY4 / SEMA6D / semaphorin 6DENSG0000013787246
Q9H3T3 / SEMA6B / semaphorin 6BENSG0000016768041
Q9H3T2 / SEMA6C / semaphorin 6CENSG0000014343434
Q13591 / SEMA5A / semaphorin 5AENSG0000011290223
Q9P283 / SEMA5B / semaphorin 5BENSG0000008268423
O75326 / SEMA7A / semaphorin 7A (John Milton Hagen blood group)ENSG0000013862314


Protein motifs (from Interpro)
Interpro ID Name
 IPR001627  Sema domain
 IPR002165  Plexin repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016201  PSI domain
 IPR027231  Semaphorin
 IPR036352  Sema domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001764 neuron migration IEA
 biological_processGO:0006915 apoptotic process NAS
 biological_processGO:0007010 cytoskeleton organization NAS
 biological_processGO:0007166 cell surface receptor signaling pathway NAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development NAS
 biological_processGO:0007411 axon guidance NAS
 biological_processGO:0009887 animal organ morphogenesis NAS
 biological_processGO:0016525 negative regulation of angiogenesis IGI
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0051642 centrosome localization IEA
 biological_processGO:0071526 semaphorin-plexin signaling pathway IEA
 biological_processGO:0106089 negative regulation of cell adhesion involved in sprouting angiogenesis IGI
 biological_processGO:1903671 negative regulation of sprouting angiogenesis IDA
 biological_processGO:2001224 positive regulation of neuron migration IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane NAS
 cellular_componentGO:0030424 axon NAS
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0030215 semaphorin receptor binding IEA


Pathways (from Reactome)
Pathway description
Other semaphorin interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000221866 PLXNA4 / Q9HCM2 / plexin A4  / complex / reaction
 ENSG00000076356 O75051 / PLXNA2 / plexin A2  / complex / reaction






 

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