ENSG00000137872


Homo sapiens

Features
Gene ID: ENSG00000137872
  
Biological name :SEMA6D
  
Synonyms : Q8NFY4 / SEMA6D / semaphorin 6D
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q21.1
Gene start: 47184101
Gene end: 47774223
  
Corresponding Affymetrix probe sets: 220574_at (Human Genome U133 Plus 2.0 Array)   226492_at (Human Genome U133 Plus 2.0 Array)   233801_s_at (Human Genome U133 Plus 2.0 Array)   233882_s_at (Human Genome U133 Plus 2.0 Array)   244746_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000453755
Ensembl peptide - ENSP00000453661
Ensembl peptide - ENSP00000453689
Ensembl peptide - ENSP00000324857
Ensembl peptide - ENSP00000346786
Ensembl peptide - ENSP00000348276
Ensembl peptide - ENSP00000350770
Ensembl peptide - ENSP00000374076
Ensembl peptide - ENSP00000374079
Ensembl peptide - ENSP00000446152
Ensembl peptide - ENSP00000452815
Ensembl peptide - ENSP00000453097
Ensembl peptide - ENSP00000453420
Ensembl peptide - ENSP00000453518
Ensembl peptide - ENSP00000453530
NCBI entrez gene - 80031     See in Manteia.
OMIM - 609295
RefSeq - XM_017022621
RefSeq - XM_005254686
RefSeq - XM_005254687
RefSeq - XM_005254689
RefSeq - XM_011522075
RefSeq - XM_011522076
RefSeq - XM_011522077
RefSeq - XM_011522078
RefSeq - XM_011522079
RefSeq - XM_011522080
RefSeq - XM_011522081
RefSeq - XM_017022617
RefSeq - XM_017022618
RefSeq - XM_017022619
RefSeq - XM_017022620
RefSeq - NM_001198999
RefSeq - NM_001358351
RefSeq - NM_020858
RefSeq - NM_024966
RefSeq - NM_153616
RefSeq - NM_153617
RefSeq - NM_153618
RefSeq - NM_153619
RefSeq - XM_005254685
RefSeq Peptide - NP_001345280
RefSeq Peptide - NP_079242
RefSeq Peptide - NP_705869
RefSeq Peptide - NP_705870
RefSeq Peptide - NP_705871
RefSeq Peptide - NP_705872
RefSeq Peptide - NP_001185928
RefSeq Peptide - NP_065909
swissprot - H0YMA6
swissprot - H0YMP7
swissprot - H0YMV0
swissprot - Q8NFY4
swissprot - H0YL82
swissprot - H0YM97
Ensembl - ENSG00000137872
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sema6dlENSDARG00000011533Danio rerio
 SEMA6DENSGALG00000030542Gallus gallus
 Q76KF0ENSMUSG00000027200Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9H2E6 / SEMA6A / semaphorin 6AENSG0000009242145
Q9H3T2 / SEMA6C / semaphorin 6CENSG0000014343437
Q9H3T3 / SEMA6B / semaphorin 6BENSG0000016768033
Q9P283 / SEMA5B / semaphorin 5BENSG0000008268422
Q13591 / SEMA5A / semaphorin 5AENSG0000011290221
O75326 / SEMA7A / semaphorin 7A (John Milton Hagen blood group)ENSG0000013862313


Protein motifs (from Interpro)
Interpro ID Name
 IPR001627  Sema domain
 IPR002165  Plexin repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016201  PSI domain
 IPR027231  Semaphorin
 IPR036352  Sema domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0014911 positive regulation of smooth muscle cell migration IEA
 biological_processGO:0014912 negative regulation of smooth muscle cell migration IEA
 biological_processGO:0021591 ventricular system development IEA
 biological_processGO:0030154 cell differentiation IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0030215 semaphorin receptor binding IEA


Pathways (from Reactome)
Pathway description
Other semaphorin interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000011600 O43914 / TYROBP / TYRO protein tyrosine kinase binding protein  / complex / reaction
 ENSG00000095970 TREM2 / Q9NZC2 / triggering receptor expressed on myeloid cells 2  / reaction / complex
 ENSG00000114554 PLXNA1 / Q9UIW2 / plexin A1  / reaction / complex






 

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