ENSG00000138623


Homo sapiens

Features
Gene ID: ENSG00000138623
  
Biological name :SEMA7A
  
Synonyms : O75326 / SEMA7A / semaphorin 7A (John Milton Hagen blood group)
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q24.1
Gene start: 74409289
Gene end: 74433958
  
Corresponding Affymetrix probe sets: 210083_at (Human Genome U133 Plus 2.0 Array)   230345_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000261918
Ensembl peptide - ENSP00000438966
Ensembl peptide - ENSP00000441493
NCBI entrez gene - 8482     See in Manteia.
OMIM - 607961
RefSeq - NM_001146029
RefSeq - NM_001146030
RefSeq - NM_003612
RefSeq Peptide - NP_001139501
RefSeq Peptide - NP_001139502
RefSeq Peptide - NP_003603
swissprot - O75326
swissprot - F5GYX3
Ensembl - ENSG00000138623
  
Related genetic diseases (OMIM): 614745 - [Blood group, John-Milton-Hagen system], 614745
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sema7aENSDARG00000078707Danio rerio
 SEMA7AENSGALG00000001412Gallus gallus
 Q9QUR8ENSMUSG00000038264Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9P283 / SEMA5B / semaphorin 5BENSG0000008268424
Q13591 / SEMA5A / semaphorin 5AENSG0000011290224
Q9H2E6 / SEMA6A / semaphorin 6AENSG0000009242123
Q9H3T3 / SEMA6B / semaphorin 6BENSG0000016768022
Q9H3T2 / SEMA6C / semaphorin 6CENSG0000014343422
Q8NFY4 / SEMA6D / semaphorin 6DENSG0000013787221


Protein motifs (from Interpro)
Interpro ID Name
 IPR001627  Sema domain
 IPR002165  Plexin repeat
 IPR007110  Immunoglobulin-like domain
 IPR013783  Immunoglobulin-like fold
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016201  PSI domain
 IPR027231  Semaphorin
 IPR036179  Immunoglobulin-like domain superfamily
 IPR036352  Sema domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001649 osteoblast differentiation HDA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006955 immune response TAS
 biological_processGO:0007229 integrin-mediated signaling pathway IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0021988 olfactory lobe development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0045773 positive regulation of axon extension IDA
 biological_processGO:0048675 axon extension IEA
 biological_processGO:0050727 regulation of inflammatory response IBA
 biological_processGO:0050919 negative chemotaxis IBA
 biological_processGO:0060907 positive regulation of macrophage cytokine production IBA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009897 external side of plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 molecular_functionGO:0005178 integrin binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0038191 neuropilin binding IBA


Pathways (from Reactome)
Pathway description
Other semaphorin interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000136040 O60486 / PLXNC1 / plexin C1  / reaction / complex
 ENSG00000213949 ITGA1 / P56199 / integrin subunit alpha 1  / reaction / complex
 ENSG00000150093 ITGB1 / P05556 / integrin subunit beta 1  / reaction / complex






 

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