ENSG00000213949


Homo sapiens

Features
Gene ID: ENSG00000213949
  
Biological name :ITGA1
  
Synonyms : integrin subunit alpha 1 / ITGA1 / P56199
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q11.2
Gene start: 52787896
Gene end: 52959210
  
Corresponding Affymetrix probe sets: 1560359_at (Human Genome U133 Plus 2.0 Array)   214660_at (Human Genome U133 Plus 2.0 Array)   226731_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000282588
NCBI entrez gene - 3672     See in Manteia.
OMIM - 192968
RefSeq - NM_181501
RefSeq Peptide - NP_852478
swissprot - P56199
Ensembl - ENSG00000213949
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itga1ENSDARG00000074316Danio rerio
 ITGA1ENSGALG00000014891Gallus gallus
 Itga1ENSMUSG00000042284Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ITGA2 / P17301 / integrin subunit alpha 2ENSG0000016417140
ITGA11 / Q9UKX5 / integrin subunit alpha 11ENSG0000013780939
ITGA10 / O75578 / integrin subunit alpha 10ENSG0000014312735
ITGAM / P11215 / integrin subunit alpha MENSG0000016989627
ITGAL / P20701 / integrin subunit alpha LENSG0000000584426
ITGAX / P20702 / integrin subunit alpha XENSG0000014067825
ITGAD / Q13349 / integrin subunit alpha DENSG0000015688625
ITGAE / P38570 / integrin subunit alpha EENSG0000008345724
ITGA7 / Q13683 / integrin subunit alpha 7ENSG0000013542421
ITGA6 / P23229 / integrin subunit alpha 6ENSG0000009140920
ITGA8 / P53708 / integrin subunit alpha 8ENSG0000007794319
ITGA3 / P26006 / integrin subunit alpha 3ENSG0000000588419
ITGA9 / Q13797 / integrin subunit alpha 9ENSG0000014466819
ITGA5 / P08648 / integrin subunit alpha 5ENSG0000016163819
ITGA4 / P13612 / integrin subunit alpha 4ENSG0000011523219
ITGAV / P06756 / integrin subunit alpha VENSG0000013844818
ITGA2B / P08514 / integrin subunit alpha 2bENSG0000000596117


Protein motifs (from Interpro)
Interpro ID Name
 IPR000413  Integrin alpha chain
 IPR002035  von Willebrand factor, type A
 IPR013517  FG-GAP repeat
 IPR013519  Integrin alpha beta-propellor
 IPR013649  Integrin alpha-2
 IPR018184  Integrin alpha chain, C-terminal cytoplasmic region, conserved site
 IPR032695  Integrin domain superfamily
 IPR036465  von Willebrand factor A-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0006936 muscle contraction TAS
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007160 cell-matrix adhesion IMP
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0030198 extracellular matrix organization TAS
 biological_processGO:0030593 neutrophil chemotaxis IEA
 biological_processGO:0032516 positive regulation of phosphoprotein phosphatase activity IDA
 biological_processGO:0042059 negative regulation of epidermal growth factor receptor signaling pathway IEA
 biological_processGO:0042311 vasodilation IEA
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0045123 cellular extravasation IEA
 biological_processGO:0048812 neuron projection morphogenesis IEA
 biological_processGO:0060326 cell chemotaxis IEA
 cellular_componentGO:0001669 acrosomal vesicle IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005925 focal adhesion IDA
 cellular_componentGO:0008305 integrin complex TAS
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0034665 integrin alpha1-beta1 complex IDA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0045178 basal part of cell IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005518 collagen binding IEA
 molecular_functionGO:0019903 protein phosphatase binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0098639 collagen binding involved in cell-matrix adhesion IMP


Pathways (from Reactome)
Pathway description
Integrin cell surface interactions
Laminin interactions
Other semaphorin interactions
Smooth Muscle Contraction
CHL1 interactions
Platelet Adhesion to exposed collagen


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000138623 O75326 / SEMA7A / semaphorin 7A (John Milton Hagen blood group)  / complex / reaction
 ENSG00000134121 CHL1 / O00533 / cell adhesion molecule L1 like  / complex / reaction
 ENSG00000150093 ITGB1 / P05556 / integrin subunit beta 1  / complex






 

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