ENSG00000140678


Homo sapiens

Features
Gene ID: ENSG00000140678
  
Biological name :ITGAX
  
Synonyms : integrin subunit alpha X / ITGAX / P20702
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: p11.2
Gene start: 31355134
Gene end: 31382997
  
Corresponding Affymetrix probe sets: 1563003_at (Human Genome U133 Plus 2.0 Array)   210184_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000483860
Ensembl peptide - ENSP00000268296
Ensembl peptide - ENSP00000454623
NCBI entrez gene - 3687     See in Manteia.
OMIM - 151510
RefSeq - XM_011545852
RefSeq - NM_000887
RefSeq - NM_001286375
RefSeq Peptide - NP_000878
RefSeq Peptide - NP_001273304
swissprot - A0A087X131
swissprot - H3BN02
swissprot - P20702
Ensembl - ENSG00000140678
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itgamENSDARG00000096587Danio rerio
 si:dkey-32n7.4ENSDARG00000002956Danio rerio
 ENSGALG00000041298Gallus gallus
 ItgaxENSMUSG00000030789Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ITGAD / Q13349 / integrin subunit alpha DENSG0000015688665
ITGAM / P11215 / integrin subunit alpha MENSG0000016989660
ITGAL / P20701 / integrin subunit alpha LENSG0000000584432
ITGA2 / P17301 / integrin subunit alpha 2ENSG0000016417127
ITGA10 / O75578 / integrin subunit alpha 10ENSG0000014312726
ITGAE / P38570 / integrin subunit alpha EENSG0000008345726
ITGA11 / Q9UKX5 / integrin subunit alpha 11ENSG0000013780926
ITGA1 / P56199 / integrin subunit alpha 1ENSG0000021394925
ITGA4 / P13612 / integrin subunit alpha 4ENSG0000011523221
ITGA5 / P08648 / integrin subunit alpha 5ENSG0000016163820
ITGA7 / Q13683 / integrin subunit alpha 7ENSG0000013542419
ITGAV / P06756 / integrin subunit alpha VENSG0000013844819
ITGA9 / Q13797 / integrin subunit alpha 9ENSG0000014466819
ITGA2B / P08514 / integrin subunit alpha 2bENSG0000000596118
ITGA3 / P26006 / integrin subunit alpha 3ENSG0000000588418
ITGA6 / P23229 / integrin subunit alpha 6ENSG0000009140918
ITGA8 / P53708 / integrin subunit alpha 8ENSG0000007794318


Protein motifs (from Interpro)
Interpro ID Name
 IPR000413  Integrin alpha chain
 IPR002035  von Willebrand factor, type A
 IPR013517  FG-GAP repeat
 IPR013519  Integrin alpha beta-propellor
 IPR013649  Integrin alpha-2
 IPR018184  Integrin alpha chain, C-terminal cytoplasmic region, conserved site
 IPR032695  Integrin domain superfamily
 IPR036465  von Willebrand factor A-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0009887 animal organ morphogenesis TAS
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0030198 extracellular matrix organization TAS
 biological_processGO:0034113 heterotypic cell-cell adhesion IMP
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0050900 leukocyte migration TAS
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion IMP
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0008305 integrin complex IEA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030667 secretory granule membrane TAS
 cellular_componentGO:0070821 tertiary granule membrane TAS
 cellular_componentGO:0101003 ficolin-1-rich granule membrane TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Cell surface interactions at the vascular wall
Integrin cell surface interactions
ECM proteoglycans
Interleukin-4 and Interleukin-13 signaling
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000150093 ITGB1 / P05556 / integrin subunit beta 1  / complex
 ENSG00000171557 FGG / P02679 / fibrinogen gamma chain  / complex / reaction
 ENSG00000171564 FGB / P02675 / fibrinogen beta chain  / complex / reaction
 ENSG00000171560 FGA / P02671 / fibrinogen alpha chain  / complex / reaction
 ENSG00000160255 ITGB2 / P05107 / integrin subunit beta 2  / complex
 ENSG00000166086 JAM3 / Q9BX67 / junctional adhesion molecule 3  / reaction / complex






 

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