ENSG00000169896


Homo sapiens

Features
Gene ID: ENSG00000169896
  
Biological name :ITGAM
  
Synonyms : integrin subunit alpha M / ITGAM / P11215
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: p11.2
Gene start: 31259990
Gene end: 31332892
  
Corresponding Affymetrix probe sets: 205785_at (Human Genome U133 Plus 2.0 Array)   205786_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000287497
Ensembl peptide - ENSP00000441691
Ensembl peptide - ENSP00000454568
Ensembl peptide - ENSP00000461850
NCBI entrez gene - 3684     See in Manteia.
OMIM - 120980
RefSeq - XM_017023216
RefSeq - NM_000632
RefSeq - NM_001145808
RefSeq - XM_011545850
RefSeq Peptide - NP_000623
RefSeq Peptide - NP_001139280
swissprot - I3NI33
swissprot - P11215
swissprot - H3BMV4
Ensembl - ENSG00000169896
  
Related genetic diseases (OMIM): 609939 - {Systemic lupus erythematous, association with susceptibility to, 6}, 609939
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itgamENSDARG00000096587Danio rerio
 si:dkey-32n7.4ENSDARG00000002956Danio rerio
 ENSGALG00000041298Gallus gallus
 ItgamENSMUSG00000108596Mus musculus
 ItgamENSMUSG00000030786Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ITGAX / P20702 / integrin subunit alpha XENSG0000014067860
ITGAD / Q13349 / integrin subunit alpha DENSG0000015688659
ITGAL / P20701 / integrin subunit alpha LENSG0000000584432
ITGA10 / O75578 / integrin subunit alpha 10ENSG0000014312727
ITGA1 / P56199 / integrin subunit alpha 1ENSG0000021394927
ITGA11 / Q9UKX5 / integrin subunit alpha 11ENSG0000013780927
ITGAE / P38570 / integrin subunit alpha EENSG0000008345727
ITGA2 / P17301 / integrin subunit alpha 2ENSG0000016417126
ITGA9 / Q13797 / integrin subunit alpha 9ENSG0000014466820
ITGA5 / P08648 / integrin subunit alpha 5ENSG0000016163820
ITGA4 / P13612 / integrin subunit alpha 4ENSG0000011523220
ITGA7 / Q13683 / integrin subunit alpha 7ENSG0000013542419
ITGAV / P06756 / integrin subunit alpha VENSG0000013844819
ITGA6 / P23229 / integrin subunit alpha 6ENSG0000009140919
ITGA3 / P26006 / integrin subunit alpha 3ENSG0000000588419
ITGA8 / P53708 / integrin subunit alpha 8ENSG0000007794318
ITGA2B / P08514 / integrin subunit alpha 2bENSG0000000596118


Protein motifs (from Interpro)
Interpro ID Name
 IPR000413  Integrin alpha chain
 IPR002035  von Willebrand factor, type A
 IPR013517  FG-GAP repeat
 IPR013519  Integrin alpha beta-propellor
 IPR013649  Integrin alpha-2
 IPR018184  Integrin alpha chain, C-terminal cytoplasmic region, conserved site
 IPR032695  Integrin domain superfamily
 IPR036465  von Willebrand factor A-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001774 microglial cell activation ISS
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006911 phagocytosis, engulfment ISS
 biological_processGO:0007155 cell adhesion TAS
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0010668 ectodermal cell differentiation IEP
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0030198 extracellular matrix organization TAS
 biological_processGO:0032930 positive regulation of superoxide anion generation ISS
 biological_processGO:0034142 toll-like receptor 4 signaling pathway TAS
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0043315 positive regulation of neutrophil degranulation IGI
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045963 negative regulation of dopamine metabolic process ISS
 biological_processGO:0050900 leukocyte migration TAS
 biological_processGO:0090314 positive regulation of protein targeting to membrane ISS
 biological_processGO:0097242 amyloid-beta clearance ISS
 biological_processGO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules NAS
 biological_processGO:1901216 positive regulation of neuron death ISS
 biological_processGO:1903980 positive regulation of microglial cell activation ISS
 biological_processGO:2000363 positive regulation of prostaglandin-E synthase activity ISS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0008305 integrin complex TAS
 cellular_componentGO:0009897 external side of plasma membrane NAS
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0034688 integrin alphaM-beta2 complex NAS
 cellular_componentGO:0035579 specific granule membrane TAS
 cellular_componentGO:0044853 plasma membrane raft IDA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0070821 tertiary granule membrane TAS
 molecular_functionGO:0001851 complement component C3b binding ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031072 heat shock protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity NAS


Pathways (from Reactome)
Pathway description
Toll Like Receptor 4 (TLR4) Cascade
Cell surface interactions at the vascular wall
Integrin cell surface interactions
Interleukin-4 and Interleukin-13 signaling
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000170458 CD14 / P08571 / CD14 molecule  / reaction / complex
 ENSG00000166086 JAM3 / Q9BX67 / junctional adhesion molecule 3  / reaction / complex
 ENSG00000169896 ITGAM / P11215 / integrin subunit alpha M  / reaction
 ENSG00000160255 ITGB2 / P05107 / integrin subunit beta 2  / reaction / complex






 

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