ENSMUSG00000108596


Mus musculus

Features
Gene ID: ENSMUSG00000108596
  
Biological name :Itgam
  
Synonyms : Itgam
  
Possible biological names infered from orthology : integrin subunit alpha M / P11215
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F3
Gene start: 128062683
Gene end: 128128160
  
Corresponding Affymetrix probe sets: 10557862 (MoGene1.0st)   1422046_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000095625
Ensembl peptide - ENSMUSP00000117120
MGI - MGI:6121583
MGI - MGI:96607
swissprot - F6YXU0
swissprot - Q3U1U4
Ensembl - ENSMUSG00000108596
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itgamENSDARG00000096587Danio rerio
 si:dkey-32n7.4ENSDARG00000002956Danio rerio
 ENSGALG00000041298Gallus gallus
 ITGAMENSG00000169896Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Itgam / integrin alpha M / P11215* / integrin subunit alpha M*ENSMUSG0000003078692
Itgad / Q3V0T4 / Integrin alpha-D / Q13349* / integrin subunit alpha D*ENSMUSG0000007036950
Itgax / Q9QXH4 / Integrin alpha-X / P20702* / integrin subunit alpha X*ENSMUSG0000003078950
Itgal / P24063 / Integrin alpha-L / P20701* / integrin subunit alpha L*ENSMUSG0000003083031
Itga1 / Q3V3R4 / Integrin alpha-1 / P56199* / integrin subunit alpha 1*ENSMUSG0000004228425
Itga11 / integrin subunit alpha 11 / Q9UKX5*ENSMUSG0000003224325
Itgae / Q60677 / integrin alpha E, epithelial-associated / P38570* / integrin subunit alpha E*ENSMUSG0000000594725
Itga2 / Q62469 / Integrin alpha-2 / P17301* / integrin subunit alpha 2*ENSMUSG0000001553324
Itga10 / integrin subunit alpha 10 / O75578*ENSMUSG0000009021024
Itga5 / P11688 / Integrin alpha-5 Integrin alpha-5 heavy chain Integrin alpha-5 light chain / P08648* / integrin subunit alpha 5*ENSMUSG0000000055518
Itga4 / integrin subunit alpha 4 / P13612*ENSMUSG0000002700918
Itga9 / B8JK39 / Integrin alpha-9 / Q13797* / integrin subunit alpha 9*ENSMUSG0000003911517
Itgav / P43406 / Integrin alpha-V Integrin alpha-V heavy chain Integrin alpha-V light chain / P06756* / integrin subunit alpha V*ENSMUSG0000002708717
Itga7 / Mus musculus integrin alpha 7 (Itga7), transcript variant 2, mRNA. / Q13683* / integrin subunit alpha 7*ENSMUSG0000002534817
Itga3 / Q62470 / Integrin alpha-3 Integrin alpha-3 heavy chain Integrin alpha-3 light chain / P26006* / integrin subunit alpha 3*ENSMUSG0000000150717
Itga2b / Q9QUM0 / integrin alpha 2b / P08514* / integrin subunit alpha 2b*ENSMUSG0000003466417
Itga8 / A2ARA8 / Integrin alpha-8 Integrin alpha-8 heavy chain Integrin alpha-8 light chain / P53708* / integrin subunit alpha 8*ENSMUSG0000002676816
Itga6 / Q61739 / Integrin alpha-6 Integrin alpha-6 heavy chain Integrin alpha-6 light chain / P23229* / integrin subunit alpha 6*ENSMUSG0000002711116


Protein motifs (from Interpro)
Interpro ID Name
 IPR000413  Integrin alpha chain
 IPR001854  Ribosomal protein L29/L35
 IPR002035  von Willebrand factor, type A
 IPR013517  FG-GAP repeat
 IPR013519  Integrin alpha beta-propellor
 IPR013649  Integrin alpha-2
 IPR032695  Integrin domain superfamily
 IPR036049  Ribosomal protein L29/L35 superfamily
 IPR036465  von Willebrand factor A-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006412 translation IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005840 ribosome IEA
 cellular_componentGO:0008305 integrin complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003735 structural constituent of ribosome IEA


Pathways (from Reactome)
Pathway description
Toll Like Receptor 4 (TLR4) Cascade
Cell surface interactions at the vascular wall
Integrin cell surface interactions
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Itgaltm1Bll/Itgaltm1Bll
Genetic Background: B6.129S7-Itgaltm1Bll

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itgaltm1Bll/Itgaltm1Bll
Genetic Background: B6.129S7-Itgaltm1Bll

Allelic Composition: Itgamtm1Myd/Itgamtm1Myd
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itgamtm1Myd/Itgamtm1Myd
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Itgamm1Btlr/Itgamm1Btlr
Genetic Background: C57BL/6J-Itgamm1Btlr

Allelic Composition: Itgamm1Btlr/Itgam+
Genetic Background: C57BL/6J-Itgamm1Btlr

 MP:0000717 abnormal lymphocyte number "deviation from the normal number of white blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itgaltm1Bll/Itgaltm1Bll
Genetic Background: B6.129S7-Itgaltm1Bll

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Itgamm1Btlr/Itgamm1Btlr
Genetic Background: C57BL/6J-Itgamm1Btlr

Allelic Composition: Itgamm1Btlr/Itgam+
Genetic Background: C57BL/6J-Itgamm1Btlr

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Itgaltm1Bll/Itgaltm1Bll
Genetic Background: B6.129S7-Itgaltm1Bll

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)17Cx/?,Tg(Ttn-Ighmbp2)45Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Itgaltm1Bll/Itgaltm1Bll
Genetic Background: B6.129S7-Itgaltm1Bll

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Scn8anur14/Scn8anur14
Genetic Background: involves: C57BL/6J

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * PL/J

Allelic Composition: Itgamtm1Myd/Itgamtm1Myd
Genetic Background: B6.129S4-Itgamtm1Myd

 MP:0002467 impaired neutrophil phagocytosis "reduced ability of these leukocytes to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * PL/J

Allelic Composition: Itgamtm1Myd/Itgamtm1Myd
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * PL/J

 MP:0003566 abnormal cell adhesion "altered ability of a cell to adhere to another cell or to a non-cellular component of the environment" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Scn8anur14/Scn8anur14
Genetic Background: involves: C57BL/6J

 MP:0003628 abnormal lymphocyte adhesion "anomaly in the number of or process by which lymphocytes adhere to the luminal aspects of high endothelial venules prior to transmigration out of the vessel" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95656]
Show

Allelic Composition: Itgaltm1Bll/Itgaltm1Bll
Genetic Background: B6.129S7-Itgaltm1Bll

Allelic Composition: Itgamtm1Bll/Itgamtm1Bll
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Itgamtm1Myd/Itgamtm1Myd
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
Show

Allelic Composition: Itgamm1Btlr/Itgamm1Btlr
Genetic Background: C57BL/6J-Itgamm1Btlr

Allelic Composition: Itgamm1Btlr/Itgam+
Genetic Background: C57BL/6J-Itgamm1Btlr

 MP:0003944 abnormal T cell subpopulation ratio "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]
Show

Allelic Composition: Itgaltm1Bll/Itgaltm1Bll
Genetic Background: B6.129S7-Itgaltm1Bll

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itgamtm1Myd/Itgamtm1Myd
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * PL/J

 MP:0005065 abnormal neutrophil morphology "structural anomaly of the granular leukocytes that have a three- to five-lobed nucleus and a cytoplasm that contains inconspicuous granules stainable by neutral dyes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itgamtm1Myd/Itgamtm1Myd
Genetic Background: B6.129S4-Itgamtm1Myd

 MP:0005074 defective granulocyte bactericidal activity "inability or reduced ability of neutrophils, eosinophils, or basophils to kill bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:5405]
Show

Allelic Composition: Syktm1Tyb/Syktm1.2Tara,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Itgaltm1Bll/Itgaltm1Bll
Genetic Background: B6.129S7-Itgaltm1Bll

 MP:0006043 decreased apoptosis "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Itgamtm1Myd/Itgamtm1Myd
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0006058 decreased cerebral infarction size "decreased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Itgamtm1Myd/Itgamtm1Myd
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itgaltm1Bll/Itgaltm1Bll
Genetic Background: B6.129S7-Itgaltm1Bll

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itgaltm1Bll/Itgaltm1Bll
Genetic Background: B6.129S7-Itgaltm1Bll

 MP:0008125 abnormal dendritic cell number "anomaly in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itgamm1Btlr/Itgamm1Btlr
Genetic Background: C57BL/6J-Itgamm1Btlr

Allelic Composition: Itgamm1Btlr/Itgam+
Genetic Background: C57BL/6J-Itgamm1Btlr

 MP:0008524 increased plasmacytoid dendritic cell number "greater number of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15596797]
Show

Allelic Composition: Itgamm1Btlr/Itgamm1Btlr
Genetic Background: C57BL/6J-Itgamm1Btlr

Allelic Composition: Itgamm1Btlr/Itgam+
Genetic Background: C57BL/6J-Itgamm1Btlr

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgamtm1Myd/Itgamtm1Myd
Genetic Background: B6.129S4-Itgamtm1Myd

 MP:0009858 abnormal cellular extravasation "any anomaly in the migration of leukocytes from the blood vessels into the surrounding tissue" [GO:0045123]
Show

Allelic Composition: Itgamtm1Bll/Itgamtm1Bll
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0020332 impaired leukocyte tethering or rolling "reduced ability or inability in the transient adhesive interactions between leukocytes and endothelial cells lining blood vessels mediated primarily by selectins and which are typically the first step in cellular extravasation" [GO:0050901, ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Itgamtm1Myd/Itgamtm1Myd
Genetic Background: involves: 129S4/SvJae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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