ENSMUSG00000042284


Mus musculus

Features
Gene ID: ENSMUSG00000042284
  
Biological name :Itga1
  
Synonyms : Integrin alpha-1 / Itga1 / Q3V3R4
  
Possible biological names infered from orthology : integrin subunit alpha 1 / P56199
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: D2.2
Gene start: 114953096
Gene end: 115101964
  
Corresponding Affymetrix probe sets: 10412298 (MoGene1.0st)   1429543_at (Mouse Genome 430 2.0 Array)   1439713_at (Mouse Genome 430 2.0 Array)   1441972_at (Mouse Genome 430 2.0 Array)   1453188_at (Mouse Genome 430 2.0 Array)   1455251_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000077132
NCBI entrez gene - 109700     See in Manteia.
MGI - MGI:96599
RefSeq - NM_001033228
RefSeq Peptide - NP_001028400
swissprot - Q3V3R4
Ensembl - ENSMUSG00000042284
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itga1ENSDARG00000074316Danio rerio
 ITGA1ENSGALG00000014891Gallus gallus
 ITGA1ENSG00000213949Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Itga11 / integrin subunit alpha 11 / Q9UKX5*ENSMUSG0000003224340
Itga2 / Q62469 / Integrin alpha-2 / P17301* / integrin subunit alpha 2*ENSMUSG0000001553339
Itga10 / integrin subunit alpha 10 / O75578*ENSMUSG0000009021036
Itgax / Q9QXH4 / Integrin alpha-X / P20702* / integrin subunit alpha X*ENSMUSG0000003078926
Itgad / Q3V0T4 / Integrin alpha-D / Q13349* / integrin subunit alpha D*ENSMUSG0000007036926
Itgam / integrin alpha M / P11215* / integrin subunit alpha M*ENSMUSG0000003078626
Itgam / P11215* / integrin subunit alpha M*ENSMUSG0000010859626
Itgal / P24063 / Integrin alpha-L / P20701* / integrin subunit alpha L*ENSMUSG0000003083026
Itgae / Q60677 / integrin alpha E, epithelial-associated / P38570* / integrin subunit alpha E*ENSMUSG0000000594723
Itga7 / Mus musculus integrin alpha 7 (Itga7), transcript variant 2, mRNA. / Q13683* / integrin subunit alpha 7*ENSMUSG0000002534821
Itga4 / integrin subunit alpha 4 / P13612*ENSMUSG0000002700920
Itga9 / B8JK39 / Integrin alpha-9 / Q13797* / integrin subunit alpha 9*ENSMUSG0000003911520
Itga8 / A2ARA8 / Integrin alpha-8 Integrin alpha-8 heavy chain Integrin alpha-8 light chain / P53708* / integrin subunit alpha 8*ENSMUSG0000002676819
Itga3 / Q62470 / Integrin alpha-3 Integrin alpha-3 heavy chain Integrin alpha-3 light chain / P26006* / integrin subunit alpha 3*ENSMUSG0000000150719
Itga5 / P11688 / Integrin alpha-5 Integrin alpha-5 heavy chain Integrin alpha-5 light chain / P08648* / integrin subunit alpha 5*ENSMUSG0000000055519
Itgav / P43406 / Integrin alpha-V Integrin alpha-V heavy chain Integrin alpha-V light chain / P06756* / integrin subunit alpha V*ENSMUSG0000002708718
Itga6 / Q61739 / Integrin alpha-6 Integrin alpha-6 heavy chain Integrin alpha-6 light chain / P23229* / integrin subunit alpha 6*ENSMUSG0000002711118
Itga2b / Q9QUM0 / integrin alpha 2b / P08514* / integrin subunit alpha 2b*ENSMUSG0000003466417


Protein motifs (from Interpro)
Interpro ID Name
 IPR000413  Integrin alpha chain
 IPR002035  von Willebrand factor, type A
 IPR013517  FG-GAP repeat
 IPR013519  Integrin alpha beta-propellor
 IPR013649  Integrin alpha-2
 IPR018184  Integrin alpha chain, C-terminal cytoplasmic region, conserved site
 IPR032695  Integrin domain superfamily
 IPR036465  von Willebrand factor A-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0007155 cell adhesion IMP
 biological_processGO:0007160 cell-matrix adhesion IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0030593 neutrophil chemotaxis IMP
 biological_processGO:0032516 positive regulation of phosphoprotein phosphatase activity IEA
 biological_processGO:0042059 negative regulation of epidermal growth factor receptor signaling pathway IMP
 biological_processGO:0042311 vasodilation IEA
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0045123 cellular extravasation IMP
 biological_processGO:0048812 neuron projection morphogenesis IEA
 biological_processGO:0060326 cell chemotaxis IEA
 cellular_componentGO:0001669 acrosomal vesicle IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0008305 integrin complex IEA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0034665 integrin alpha1-beta1 complex IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0045178 basal part of cell IDA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005518 collagen binding IEA
 molecular_functionGO:0019903 protein phosphatase binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0098639 collagen binding involved in cell-matrix adhesion IEA


Pathways (from Reactome)
Pathway description
Integrin cell surface interactions
Smooth Muscle Contraction


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ins2Akita/Ins2+
Genetic Background: C.B6N-Ins2Akita

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgl2tm1Pam/Fgl2+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002704 tubular nephritis "inflammation of the renal tubules" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Col4a3tm1Dec/Col4a3tm1Dec,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * BALB/c

 MP:0002871 albuminuria "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0002965 hyperalbuminemia "blood albumin concentration above the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0003606 kidney failure "cessation of renal function" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Col4a3tm1Dec/Col4a3tm1Dec,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * BALB/c

 MP:0005165 increased susceptibility to injury "greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005264 glomerulosclerosis "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005527 increased glomerular filtration rate "greater than the normal volume of water filtered out of the plasma through glomerular capillary walls into thte Bowman s capsule per unit time" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005568 increased circulating total protein level "greater than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]
Show

Allelic Composition: Col4a3tm1Dec/Col4a3tm1Dec,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * BALB/c

 MP:0008140 podocyte foot process effacement "thinning of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0011320 abnormal glomerular capillary morphology "any structural anomaly of the small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles; these capillaries are under high pressure for filtering within the glomerulus" [MGI:csmith]
Show

Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0011339 abnormal glomerular mesangium morphology "any structural anomaly of the inner layer of the glomerulus within the basement membrane surrounding the glomerular capillaries that contain the intraglomerular mesangial cells" [MGI:csmith]
Show

Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0011348 abnormal renal glomerulus basement membrane morphology "any structural anomaly of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule; it is a fusion of the endothelial cell and podocyte basal laminas and acts as a physical barrier and an ion-selective filter" [MGI:anna]
Show

Allelic Composition: Col4a3tm1Dec/Col4a3tm1Dec,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * BALB/c

 MP:0011353 expanded mesangial matrix "increase in the amount of mesangial matrix present in the basement membrane surrounding the glomerular capillaries that also contain the intraglomerular mesangial cells" [MGI:csmith]
Show

Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0011369 increased renal glomerulus apoptosis "increase in the number of cells of the kidney glomerulus undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0011409 increased renal glomerulus basement membrane thickness "increased width of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule" [MGI:anna]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0011425 abnormal kidney interstitium morphology "any structural anomaly of the kidney region located between the nephrons, ureteric epithelia (ureteric tips, trunk and collecting duct system) and renal vasculature, and composed of renal support cells, including fibroblasts and macrophages, and mesenchymal stroma or interstitial cells; the renal vasculature lies within the renal interstitium but is not a part of it; various conditions can lead to scarring (fibrosis) and congestion of this area, which can cause kidney dysfunction and failure" [MGI:anna]
Show

Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0011430 mesangiolysis "an injurious glomerular process that affects primarily the mesangium, starting with loosening and detachment of its matrix and progressing to dissolution/attenuation with degeneration of mesangial cells; mesangial cells may show only edema and vacuolization, or may undergo severe degeneration and necrosis" [MGI:anna]
Show

Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0020518 renal glomerular protein deposits "any anomalous accumulation of protein in the renal glomerulus" [HP:0030949]
Show

Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030077 Chl1 / P70232 / Neural cell adhesion molecule L1-like protein Processed neural cell adhesion molecule L1-like protein / O00533* / cell adhesion molecule L1 like*  / complex / reaction
 ENSMUSG00000038264 Q9QUR8 / Sema7a / Semaphorin-7A / O75326* / semaphorin 7A (John Milton Hagen blood group)*  / complex / reaction
 ENSMUSG00000025809 Itgb1 / P09055 / Integrin beta-1 / P05556* / integrin subunit beta 1*  / complex






 

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