ENSMUSG00000005947


Mus musculus

Features
Gene ID: ENSMUSG00000005947
  
Biological name :Itgae
  
Synonyms : integrin alpha E, epithelial-associated / Itgae / Q60677
  
Possible biological names infered from orthology : integrin subunit alpha E / P38570
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B4
Gene start: 73090583
Gene end: 73147446
  
Corresponding Affymetrix probe sets: 10378286 (MoGene1.0st)   1447541_s_at (Mouse Genome 430 2.0 Array)   1449216_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000006101
Ensembl peptide - ENSMUSP00000099596
NCBI entrez gene - 16407     See in Manteia.
MGI - MGI:1298377
RefSeq - XM_017314299
RefSeq - NM_008399
RefSeq - NM_172944
RefSeq Peptide - NP_766532
RefSeq Peptide - NP_032425
swissprot - Q60677
swissprot - Q8BS01
Ensembl - ENSMUSG00000005947
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itgae.1ENSDARG00000098012Danio rerio
 itgae.2ENSDARG00000057787Danio rerio
 ITGAEENSG00000083457Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Itgam / integrin alpha M / P11215* / integrin subunit alpha M*ENSMUSG0000003078627
Itgam / P11215* / integrin subunit alpha M*ENSMUSG0000010859627
Itgad / Q3V0T4 / Integrin alpha-D / Q13349* / integrin subunit alpha D*ENSMUSG0000007036926
Itgax / Q9QXH4 / Integrin alpha-X / P20702* / integrin subunit alpha X*ENSMUSG0000003078926
Itgal / P24063 / Integrin alpha-L / P20701* / integrin subunit alpha L*ENSMUSG0000003083025
Itga2 / Q62469 / Integrin alpha-2 / P17301* / integrin subunit alpha 2*ENSMUSG0000001553324
Itga11 / integrin subunit alpha 11 / Q9UKX5*ENSMUSG0000003224324
Itga1 / Q3V3R4 / Integrin alpha-1 / P56199* / integrin subunit alpha 1*ENSMUSG0000004228424
Itga10 / integrin subunit alpha 10 / O75578*ENSMUSG0000009021024
Itga3 / Q62470 / Integrin alpha-3 Integrin alpha-3 heavy chain Integrin alpha-3 light chain / P26006* / integrin subunit alpha 3*ENSMUSG0000000150718
Itga6 / Q61739 / Integrin alpha-6 Integrin alpha-6 heavy chain Integrin alpha-6 light chain / P23229* / integrin subunit alpha 6*ENSMUSG0000002711118
Itga4 / integrin subunit alpha 4 / P13612*ENSMUSG0000002700918
Itga9 / B8JK39 / Integrin alpha-9 / Q13797* / integrin subunit alpha 9*ENSMUSG0000003911518
Itga7 / Mus musculus integrin alpha 7 (Itga7), transcript variant 2, mRNA. / Q13683* / integrin subunit alpha 7*ENSMUSG0000002534817
Itga5 / P11688 / Integrin alpha-5 Integrin alpha-5 heavy chain Integrin alpha-5 light chain / P08648* / integrin subunit alpha 5*ENSMUSG0000000055517
Itga8 / A2ARA8 / Integrin alpha-8 Integrin alpha-8 heavy chain Integrin alpha-8 light chain / P53708* / integrin subunit alpha 8*ENSMUSG0000002676817
Itgav / P43406 / Integrin alpha-V Integrin alpha-V heavy chain Integrin alpha-V light chain / P06756* / integrin subunit alpha V*ENSMUSG0000002708716
Itga2b / Q9QUM0 / integrin alpha 2b / P08514* / integrin subunit alpha 2b*ENSMUSG0000003466415


Protein motifs (from Interpro)
Interpro ID Name
 IPR000413  Integrin alpha chain
 IPR002035  von Willebrand factor, type A
 IPR013517  FG-GAP repeat
 IPR013519  Integrin alpha beta-propellor
 IPR013649  Integrin alpha-2
 IPR018184  Integrin alpha chain, C-terminal cytoplasmic region, conserved site
 IPR032695  Integrin domain superfamily
 IPR036465  von Willebrand factor A-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 cellular_componentGO:0008305 integrin complex IEA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Integrin cell surface interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88+
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Apobtm2Sgy/Apobtm4Sgy
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Apobtm2Sgy/Apobtm4Sgy
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000303 Cdh1 / cadherin 1 / P12830*  / complex / reaction
 ENSMUSG00000001281 Itgb7 / P26011 / Integrin beta-7 / P26010* / integrin subunit beta 7*  / complex






 

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