ENSMUSG00000070369


Mus musculus

Features
Gene ID: ENSMUSG00000070369
  
Biological name :Itgad
  
Synonyms : Integrin alpha-D / Itgad / Q3V0T4
  
Possible biological names infered from orthology : integrin subunit alpha D / Q13349
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F3
Gene start: 128154376
Gene end: 128223816
  
Corresponding Affymetrix probe sets: 10557928 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000101844
Ensembl peptide - ENSMUSP00000135309
Ensembl peptide - ENSMUSP00000135572
Ensembl peptide - ENSMUSP00000033051
Ensembl peptide - ENSMUSP00000135104
NCBI entrez gene - 381924     See in Manteia.
MGI - MGI:3578624
RefSeq - XM_006507972
RefSeq - NM_001029872
RefSeq - XM_006507971
RefSeq Peptide - NP_001025043
swissprot - H3BJS4
swissprot - E9PXZ7
swissprot - Q3V0T4
swissprot - H3BKA0
swissprot - H3BKX8
Ensembl - ENSMUSG00000070369
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itgamENSDARG00000096587Danio rerio
 si:dkey-32n7.4ENSDARG00000002956Danio rerio
 ENSGALG00000041298Gallus gallus
 ITGADENSG00000156886Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Itgax / Q9QXH4 / Integrin alpha-X / P20702* / integrin subunit alpha X*ENSMUSG0000003078962
Itgam / integrin alpha M / P11215* / integrin subunit alpha M*ENSMUSG0000003078651
Itgam / P11215* / integrin subunit alpha M*ENSMUSG0000010859651
Itgal / P24063 / Integrin alpha-L / P20701* / integrin subunit alpha L*ENSMUSG0000003083029
Itga11 / integrin subunit alpha 11 / Q9UKX5*ENSMUSG0000003224327
Itga10 / integrin subunit alpha 10 / O75578*ENSMUSG0000009021026
Itgae / Q60677 / integrin alpha E, epithelial-associated / P38570* / integrin subunit alpha E*ENSMUSG0000000594725
Itga1 / Q3V3R4 / Integrin alpha-1 / P56199* / integrin subunit alpha 1*ENSMUSG0000004228425
Itga2 / Q62469 / Integrin alpha-2 / P17301* / integrin subunit alpha 2*ENSMUSG0000001553324
Itga5 / P11688 / Integrin alpha-5 Integrin alpha-5 heavy chain Integrin alpha-5 light chain / P08648* / integrin subunit alpha 5*ENSMUSG0000000055519
Itga9 / B8JK39 / Integrin alpha-9 / Q13797* / integrin subunit alpha 9*ENSMUSG0000003911519
Itga4 / integrin subunit alpha 4 / P13612*ENSMUSG0000002700919
Itgav / P43406 / Integrin alpha-V Integrin alpha-V heavy chain Integrin alpha-V light chain / P06756* / integrin subunit alpha V*ENSMUSG0000002708719
Itga2b / Q9QUM0 / integrin alpha 2b / P08514* / integrin subunit alpha 2b*ENSMUSG0000003466418
Itga7 / Mus musculus integrin alpha 7 (Itga7), transcript variant 2, mRNA. / Q13683* / integrin subunit alpha 7*ENSMUSG0000002534818
Itga3 / Q62470 / Integrin alpha-3 Integrin alpha-3 heavy chain Integrin alpha-3 light chain / P26006* / integrin subunit alpha 3*ENSMUSG0000000150718
Itga6 / Q61739 / Integrin alpha-6 Integrin alpha-6 heavy chain Integrin alpha-6 light chain / P23229* / integrin subunit alpha 6*ENSMUSG0000002711117
Itga8 / A2ARA8 / Integrin alpha-8 Integrin alpha-8 heavy chain Integrin alpha-8 light chain / P53708* / integrin subunit alpha 8*ENSMUSG0000002676817


Protein motifs (from Interpro)
Interpro ID Name
 IPR000413  Integrin alpha chain
 IPR002035  von Willebrand factor, type A
 IPR013517  FG-GAP repeat
 IPR013519  Integrin alpha beta-propellor
 IPR013649  Integrin alpha-2
 IPR018184  Integrin alpha chain, C-terminal cytoplasmic region, conserved site
 IPR032695  Integrin domain superfamily
 IPR036465  von Willebrand factor A-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0034113 heterotypic cell-cell adhesion IEA
 biological_processGO:0050798 activated T cell proliferation IMP
 cellular_componentGO:0008305 integrin complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Integrin cell surface interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000717 abnormal lymphocyte number "deviation from the normal number of white blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itgaltm1Bll/Itgaltm1Bll
Genetic Background: B6.129S7-Itgaltm1Bll

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Spint1Gt(OST380474)Lex/Spint1Gt(OST380474)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0001793 altered susceptibility to infection "a change in the likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Spint1Gt(OST380474)Lex/Spint1Gt(OST380474)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Itgaltm1Bll/Itgaltm1Bll
Genetic Background: B6.129S7-Itgaltm1Bll

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Spint1Gt(OST380474)Lex/Spint1Gt(OST380474)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Spint1Gt(OST380474)Lex/Spint1Gt(OST380474)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0003944 abnormal T cell subpopulation ratio "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]
Show

Allelic Composition: Itgaltm1Bll/Itgaltm1Bll
Genetic Background: B6.129S7-Itgaltm1Bll

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spint1Gt(OST380474)Lex/Spint1Gt(OST380474)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0005026 decreased susceptibility to parasitic infection "reduced likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Spint1Gt(OST380474)Lex/Spint1Gt(OST380474)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Itgaltm1Bll/Itgaltm1Bll
Genetic Background: B6.129S7-Itgaltm1Bll

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itgaltm1Bll/Itgaltm1Bll
Genetic Background: B6.129S7-Itgaltm1Bll

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itgaltm1Bll/Itgaltm1Bll
Genetic Background: B6.129S7-Itgaltm1Bll

 MP:0008617 increased circulating interleukin-12 level "increase in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
Show

Allelic Composition: Spint1Gt(OST380474)Lex/Spint1Gt(OST380474)Lex
Genetic Background: involves: 129S5/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000033831 Fgb / Q8K0E8 / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain / P02675* / fibrinogen beta chain*  / complex / reaction
 ENSMUSG00000033860 Fgg / Q8VCM7 / Fibrinogen gamma chain / P02679*  / complex / reaction
 ENSMUSG00000028001 Fga / E9PV24 / Fibrinogen alpha chain Fibrinopeptide A Fibrinogen alpha chain / P02671* / fibrinogen alpha chain*  / complex / reaction






 

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