ENSMUSG00000033860


Mus musculus

Features
Gene ID: ENSMUSG00000033860
  
Biological name :Fgg
  
Synonyms : Fgg / Fibrinogen gamma chain / Q8VCM7
  
Possible biological names infered from orthology : P02679
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: E3
Gene start: 83007724
Gene end: 83015049
  
Corresponding Affymetrix probe sets: 10492735 (MoGene1.0st)   1416025_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000037018
Ensembl peptide - ENSMUSP00000141648
NCBI entrez gene - 99571     See in Manteia.
MGI - MGI:95526
RefSeq - NM_133862
RefSeq - NM_001317105
RefSeq Peptide - NP_001304034
RefSeq Peptide - NP_598623
swissprot - Q3UEM7
swissprot - Q3UER8
swissprot - Q8VCM7
Ensembl - ENSMUSG00000033860
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fggENSDARG00000037281Danio rerio
 FGGENSGALG00000009268Gallus gallus
 FGGENSG00000171557Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fgb / Q8K0E8 / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain / P02675* / fibrinogen beta chain*ENSMUSG0000003383129
Fga / E9PV24 / Fibrinogen alpha chain Fibrinopeptide A Fibrinogen alpha chain / P02671* / fibrinogen alpha chain*ENSMUSG0000002800128
Fgl1 / fibrinogen like 1 / Q08830*ENSMUSG0000003159426
Tnn / Q80Z71 / Tenascin-N / Q9UQP3*ENSMUSG0000002672525
Tnr / Q8BYI9 / Tenascin-R / Q92752*ENSMUSG0000001582923
Q9R182 / Angptl3 / Angiopoietin-related protein 3 ANGPTL3(17-224) / Q9Y5C1* / angiopoietin like 3*ENSMUSG0000002855323
Tnc / Q80YX1 / tenascin C / P24821*ENSMUSG0000002836423
Tnxb / tenascin XB / P22105*ENSMUSG0000003332723
Q9Z1P8 / Angptl4 / Angiopoietin-related protein 4 / Q9BY76* / angiopoietin like 4*ENSMUSG0000000228922
Fn1 / P11276 / Fibronectin Anastellin / P02751* / fibronectin 1*ENSMUSG0000002619316


Protein motifs (from Interpro)
Interpro ID Name
 IPR002181  Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
 IPR012290  Fibrinogen, alpha/beta/gamma chain, coiled coil domain
 IPR014715  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
 IPR014716  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
 IPR020837  Fibrinogen, conserved site
 IPR036056  Fibrinogen-like, C-terminal
 IPR037581  Fibrinogen gamma chain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0007160 cell-matrix adhesion IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007596 blood coagulation IEA
 biological_processGO:0007599 hemostasis IEA
 biological_processGO:0009306 protein secretion IEA
 biological_processGO:0030168 platelet activation IEA
 biological_processGO:0031639 plasminogen activation IEA
 biological_processGO:0034116 positive regulation of heterotypic cell-cell adhesion IEA
 biological_processGO:0034622 cellular protein-containing complex assembly IEA
 biological_processGO:0036345 platelet maturation IEA
 biological_processGO:0042730 fibrinolysis IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045907 positive regulation of vasoconstriction IEA
 biological_processGO:0045921 positive regulation of exocytosis IEA
 biological_processGO:0050714 positive regulation of protein secretion IEA
 biological_processGO:0051258 protein polymerization IEA
 biological_processGO:0051592 response to calcium ion IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070527 platelet aggregation IEA
 biological_processGO:0071347 cellular response to interleukin-1 IEA
 biological_processGO:0071354 cellular response to interleukin-6 IEA
 biological_processGO:0072378 blood coagulation, fibrin clot formation IEA
 biological_processGO:0090277 positive regulation of peptide hormone secretion IEA
 biological_processGO:0090331 negative regulation of platelet aggregation IEA
 biological_processGO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
 biological_processGO:2000352 negative regulation of endothelial cell apoptotic process IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005577 fibrinogen complex IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005938 cell cortex IDA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0031091 platelet alpha granule IEA
 cellular_componentGO:0072562 blood microparticle IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0030674 protein binding, bridging IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050839 cell adhesion molecule binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Common Pathway of Fibrin Clot Formation
Integrin cell surface interactions
Integrin alphaIIb beta3 signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
MAP2K and MAPK activation
Regulation of TLR by endogenous ligand
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000182 increased circulating LDL cholesterol level "greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Apobec1tm1Ddsn/Apobec1tm1Ddsn,Fggtm1Fjc/Fggtm1Fjc,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.129-Fggtm1Fjc Apobec1tm1Ddsn Ldlrtm1Her

 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fggtm1Lord/Fggtm1Lord
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fggtm1Lord/Fggtm1Lord
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
Show

Allelic Composition: F9tm1Emg/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: F9tm1Emg/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0001711 abnormal placenta 
Show

Allelic Composition: F9tm1Emg/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0001712 abnormal placental development "malformed or incomplete differentiation of the organ of metabolic exchange between the fetus and mother" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: F9tm1Emg/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
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Allelic Composition: F9tm1Emg/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
Show

Allelic Composition: F9tm1Emg/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: F9tm1Emg/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Fggtm1Lord/Fggtm1Lord
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tcf3tm1Wein/Tcf3+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tcf3tm1Wein/Tcf3+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: F9tm1Emg/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Fggtm1Lord/Fggtm1Lord
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Fggtm1Lord/Fgg+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apobec1tm1Ddsn/Apobec1tm1Ddsn,Fggtm1Fjc/Fggtm1Fjc,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.129-Fggtm1Fjc Apobec1tm1Ddsn Ldlrtm1Her

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fggtm1Lord/Fggtm1Lord
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003422 abnormal thrombolysis "altered ability to break up (lyse) blood clots that are restricting the blood flow" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:17427]
Show

Allelic Composition: Fggtm1Lord/Fggtm1Lord
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Fggtm1Lord/Fgg+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004244 abnormal spontaneous abortion rate "change in frequency of a natural or accidental termination of a pregnancy at a stage where the embryo or the fetus is incapable of surviving independently of the mother" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: F9tm1Emg/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0004259 small placenta "reduced size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: F9tm1Emg/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0004898 uterine hemorrhage "presence of bleeding in the uterus; often in response to failed pregnancy" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: F9tm1Emg/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Fggtm1Lord/Fggtm1Lord
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005048 thrombosis "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fggtm1Lord/Fggtm1Lord
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005338 atherosclerotic lesions "thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Apobec1tm1Ddsn/Apobec1tm1Ddsn,Fggtm1Fjc/Fggtm1Fjc,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.129-Fggtm1Fjc Apobec1tm1Ddsn Ldlrtm1Her

 MP:0005435 hemoperitoneum "blood in the peritoneal cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87293]
Show

Allelic Composition: Atp2a2tm1Fwuy/Atp2a2tm1Fwuy,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129 * FVB/N * Swiss

Allelic Composition: Fggtm1Lord/Fggtm1Lord
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005606 increased bleeding time "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Atp2a2tm1Fwuy/Atp2a2tm1Fwuy,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129 * FVB/N * Swiss

 MP:0009549 impaired platelet aggregation "decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
Show

Allelic Composition: Atp2a2tm1Fwuy/Atp2a2tm1Fwuy,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129 * FVB/N * Swiss

 MP:0010213 abnormal circulating fibrinogen level "deviation from the normal levels in the blood of a globulin that is converted into fibrin by the action of thrombin in the presence of ionized calcium to produce coagulation of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fggtm1Lord/Fggtm1Lord
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Fggtm1Lord/Fgg+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Fggtm1Lord/Fggtm1Lord
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apobec1tm1Ddsn/Apobec1tm1Ddsn,Fggtm1Fjc/Fggtm1Fjc,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.129-Fggtm1Fjc Apobec1tm1Ddsn Ldlrtm1Her

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / reaction / complex
 ENSMUSG00000020689 Itgb3 / O54890 / Integrin beta-3 / P05106* / AC068234.1* / integrin subunit beta 3*  / complex / reaction
 ENSMUSG00000025779 Ly96 / Q9JHF9 / lymphocyte antigen 96 / Q9Y6Y9*  / reaction / complex
 ENSMUSG00000070369 Itgad / Q3V0T4 / Integrin alpha-D / Q13349* / integrin subunit alpha D*  / reaction / complex
 ENSMUSG00000027249 F2 / P19221 / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain / P00734* / coagulation factor II, thrombin*  / reaction
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000032312 Csk / P41241 / Tyrosine-protein kinase CSK / P41240* / C-terminal Src kinase*  / reaction / complex
 ENSMUSG00000027540 Ptpn1 / P35821 / protein tyrosine phosphatase, non-receptor type 1 / P18031*  / reaction
 ENSMUSG00000028001 Fga / E9PV24 / Fibrinogen alpha chain Fibrinopeptide A Fibrinogen alpha chain / P02671* / fibrinogen alpha chain*  / reaction / complex
 ENSMUSG00000030789 Itgax / Q9QXH4 / Integrin alpha-X / P20702* / integrin subunit alpha X*  / reaction / complex
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / reaction / complex
 ENSMUSG00000021457 Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*  / complex / reaction
 ENSMUSG00000039005 Tlr4 / Q9QUK6 / toll-like receptor 4 / O00206*  / complex / reaction
 ENSMUSG00000033860 Fgg / Q8VCM7 / Fibrinogen gamma chain / P02679*  / complex / reaction
 ENSMUSG00000028465 Tln1 / P26039 / talin 1 / Q9Y490*  / reaction / complex
 ENSMUSG00000033831 Fgb / Q8K0E8 / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain / P02675* / fibrinogen beta chain*  / complex / reaction
 ENSMUSG00000031955 Bcar1 / Q61140 / Breast cancer anti-estrogen resistance protein 1 / P56945* / BCAR1, Cas family scaffolding protein*  / complex / reaction
 ENSMUSG00000017776 Crk / Q64010 / Adapter molecule crk / P46108* / CRK proto-oncogene, adaptor protein*  / complex / reaction
 ENSMUSG00000052681 Rap1b / Q99JI6 / RAS related protein 1b / P61224* / RAP1B, member of RAS oncogene family*  / reaction / complex
 ENSMUSG00000021823 Vcl / Q64727 / vinculin / P18206*  / complex
 ENSMUSG00000034664 Itga2b / Q9QUM0 / integrin alpha 2b / P08514* / integrin subunit alpha 2b*  / reaction / complex
 ENSMUSG00000022607 Ptk2 / P34152 / PTK2 protein tyrosine kinase 2 / Q05397* / protein tyrosine kinase 2*  / complex / reaction
 ENSMUSG00000026786 Q8R5A3 / Apbb1ip / amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein / Q7Z5R6* / amyloid beta precursor protein binding family B member 1 interacting protein*  / complex / reaction
 ENSMUSG00000068798 Rap1a / P62835 / RAS-related protein 1a / P62834* / RAP1A, member of RAS oncogene family*  / complex / reaction






 

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