ENSMUSG00000015829


Mus musculus

Features
Gene ID: ENSMUSG00000015829
  
Biological name :Tnr
  
Synonyms : Q8BYI9 / Tenascin-R / Tnr
  
Possible biological names infered from orthology : Q92752
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H1
Gene start: 159523769
Gene end: 159931729
  
Corresponding Affymetrix probe sets: 10350951 (MoGene1.0st)   1436148_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000141752
Ensembl peptide - ENSMUSP00000107298
Ensembl peptide - ENSMUSP00000141509
Ensembl peptide - ENSMUSP00000141553
NCBI entrez gene - 21960     See in Manteia.
MGI - MGI:99516
RefSeq - XM_006496746
RefSeq - XM_006496742
RefSeq - XM_006496743
RefSeq - XM_006496744
RefSeq - XM_006496745
RefSeq - NM_022312
RefSeq Peptide - NP_071707
swissprot - A0A0A6YWY3
swissprot - A0A0A6YWD9
swissprot - Q8BYI9
Ensembl - ENSMUSG00000015829
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tnrENSDARG00000020771Danio rerio
 TNRENSGALG00000004526Gallus gallus
 TNRENSG00000116147Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tnc / Q80YX1 / tenascin C / P24821*ENSMUSG0000002836444
Tnn / Q80Z71 / Tenascin-N / Q9UQP3*ENSMUSG0000002672534
Tnxb / tenascin XB / P22105*ENSMUSG0000003332731
Fn1 / P11276 / Fibronectin Anastellin / P02751* / fibronectin 1*ENSMUSG0000002619323
Fga / E9PV24 / Fibrinogen alpha chain Fibrinopeptide A Fibrinogen alpha chain / P02671* / fibrinogen alpha chain*ENSMUSG0000002800111
Q9R182 / Angptl3 / Angiopoietin-related protein 3 ANGPTL3(17-224) / Q9Y5C1* / angiopoietin like 3*ENSMUSG000000285538
Fgb / Q8K0E8 / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain / P02675* / fibrinogen beta chain*ENSMUSG000000338318
Fgg / Q8VCM7 / Fibrinogen gamma chain / P02679*ENSMUSG000000338608
Fgl1 / fibrinogen like 1 / Q08830*ENSMUSG000000315948
Q9Z1P8 / Angptl4 / Angiopoietin-related protein 4 / Q9BY76* / angiopoietin like 4*ENSMUSG000000022897


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR002181  Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
 IPR003961  Fibronectin type III
 IPR013032  EGF-like, conserved site
 IPR013783  Immunoglobulin-like fold
 IPR014715  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
 IPR014716  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
 IPR033079  Tenascin-R
 IPR036056  Fibrinogen-like, C-terminal
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007158 neuron cell-cell adhesion IMP
 biological_processGO:0008306 associative learning IMP
 biological_processGO:0010977 negative regulation of neuron projection development IDA
 biological_processGO:0022029 telencephalon cell migration IMP
 biological_processGO:0022408 negative regulation of cell-cell adhesion IMP
 biological_processGO:0030198 extracellular matrix organization IMP
 biological_processGO:0030517 negative regulation of axon extension IDA
 biological_processGO:0035641 locomotory exploration behavior IMP
 biological_processGO:0048692 negative regulation of axon extension involved in regeneration IMP
 biological_processGO:0050767 regulation of neurogenesis IEA
 biological_processGO:0050804 modulation of chemical synaptic transmission IMP
 biological_processGO:0050805 negative regulation of synaptic transmission IMP
 biological_processGO:0050808 synapse organization IMP
 biological_processGO:0050885 neuromuscular process controlling balance IMP
 biological_processGO:0051968 positive regulation of synaptic transmission, glutamatergic IMP
 biological_processGO:0051971 positive regulation of transmission of nerve impulse IMP
 biological_processGO:0060291 long-term synaptic potentiation IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0045121 membrane raft IDA
 cellular_componentGO:0072534 perineuronal net IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0046625 sphingolipid binding TAS


Pathways (from Reactome)
Pathway description
ECM proteoglycans


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003632 abnormal nervous system morphology 
Show

Allelic Composition: Pafah1b2tm1Arai/Pafah1b2tm1Arai,Pafah1b3tm1Arai/Pafah1b3tm1Arai
Genetic Background: involves: 129X1/SvJ * C57BL/6N

 MP:0004792 abnormal synaptic vesicle number "anomaly in the number of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pafah1b2tm1Arai/Pafah1b2tm1Arai,Pafah1b3tm1Arai/Pafah1b3tm1Arai
Genetic Background: involves: 129X1/SvJ * C57BL/6N

 MP:0008263 abnormal hippocampus CA1 region morphology 
Show

Allelic Composition: Pafah1b2tm1Arai/Pafah1b2tm1Arai,Pafah1b3tm1Arai/Pafah1b3tm1Arai
Genetic Background: involves: 129X1/SvJ * C57BL/6N

 MP:0008284 abnormal hippocampus pyramidal cell layer 
Show

Allelic Composition: Pafah1b2tm1Arai/Pafah1b2tm1Arai,Pafah1b3tm1Arai/Pafah1b3tm1Arai
Genetic Background: involves: 129X1/SvJ * C57BL/6N

 MP:0008814 reduced nerve conduction velocity "decrease in the rate at which an eletrical impulse travels through a nerve" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pafah1b2tm1Arai/Pafah1b2tm1Arai,Pafah1b3tm1Arai/Pafah1b3tm1Arai
Genetic Background: involves: 129X1/SvJ * C57BL/6N

 MP:0009538 abnormal synapse morphology "any strucutral anomaly of the membrane junction site of a nerve cell to a target cell, such as another nerve cell, an effector cell, or a sensory receptor cell; transmission of nerve impulses may be mediated by chemical or by electrical means" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.850]
Show

Allelic Composition: Pafah1b2tm1Arai/Pafah1b2tm1Arai,Pafah1b3tm1Arai/Pafah1b3tm1Arai
Genetic Background: involves: 129X1/SvJ * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026193 Fn1 / P11276 / Fibronectin Anastellin / P02751* / fibronectin 1*  / reaction / complex
 ENSMUSG00000015829 Tnr / Q8BYI9 / Tenascin-R / Q92752*  / complex






 

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