ENSMUSG00000002289


Mus musculus

Features
Gene ID: ENSMUSG00000002289
  
Biological name :Angptl4
  
Synonyms : Angiopoietin-related protein 4 / Angptl4 / Q9Z1P8
  
Possible biological names infered from orthology : angiopoietin like 4 / Q9BY76
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: B1
Gene start: 33773750
Gene end: 33781575
  
Corresponding Affymetrix probe sets: 10450038 (MoGene1.0st)   1417130_s_at (Mouse Genome 430 2.0 Array)   1453410_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000002360
Ensembl peptide - ENSMUSP00000133417
NCBI entrez gene - 57875     See in Manteia.
MGI - MGI:1888999
RefSeq - NM_020581
RefSeq Peptide - NP_065606
swissprot - G3UWT7
swissprot - Q9Z1P8
Ensembl - ENSMUSG00000002289
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 angptl4ENSDARG00000035859Danio rerio
 ANGPTL4ENSGALG00000000619Gallus gallus
 Q9BY76ENSG00000167772Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9R182 / Angptl3 / Angiopoietin-related protein 3 ANGPTL3(17-224) / Q9Y5C1* / angiopoietin like 3*ENSMUSG0000002855331
Fgg / Q8VCM7 / Fibrinogen gamma chain / P02679*ENSMUSG0000003386024
Fga / E9PV24 / Fibrinogen alpha chain Fibrinopeptide A Fibrinogen alpha chain / P02671* / fibrinogen alpha chain*ENSMUSG0000002800123
Tnxb / tenascin XB / P22105*ENSMUSG0000003332723
Fgb / Q8K0E8 / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain / P02675* / fibrinogen beta chain*ENSMUSG0000003383122
Tnc / Q80YX1 / tenascin C / P24821*ENSMUSG0000002836422
Tnr / Q8BYI9 / Tenascin-R / Q92752*ENSMUSG0000001582922
Tnn / Q80Z71 / Tenascin-N / Q9UQP3*ENSMUSG0000002672521
Fgl1 / fibrinogen like 1 / Q08830*ENSMUSG0000003159420
Fn1 / P11276 / Fibronectin Anastellin / P02751* / fibronectin 1*ENSMUSG0000002619315


Protein motifs (from Interpro)
Interpro ID Name
 IPR002181  Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
 IPR014715  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
 IPR014716  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
 IPR020837  Fibrinogen, conserved site
 IPR028793  Angiopoietin-related protein 4
 IPR036056  Fibrinogen-like, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0009267 cellular response to starvation NAS
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045834 positive regulation of lipid metabolic process NAS
 biological_processGO:0051005 negative regulation of lipoprotein lipase activity IEA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0070328 triglyceride homeostasis IMP
 biological_processGO:2000352 negative regulation of endothelial cell apoptotic process IDA
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0004857 enzyme inhibitor activity IDA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Assembly of active LPL and LIPC lipase complexes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Grb2tm1Paw/Grb2+,Ptentm2Mak/Ptentm2Mak,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Angptl4tm1Lex/Angptl4tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0000511 abnormal intestinal mucosa morphology "structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Grb2tm1Paw/Grb2+,Ptentm2Mak/Ptentm2Mak,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Angptl4tm1Lex/Angptl4tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Angptl3tm1Akos/Angptl3tm1Akos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001333 absent optic nerve "absence of the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Alg10btm1(KOMP)Vlcg/Alg10btm1(KOMP)Vlcg
Genetic Background: C57BL/6N-Alg10btm1(KOMP)Vlcg/Bay

 MP:0001879 abnormal lymphatic vessel morphology "malformation of the network of vessels which carries lymph around the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Grb2tm1Paw/Grb2+,Ptentm2Mak/Ptentm2Mak,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Angptl4tm1Lex/Angptl4tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Grb2tm1Paw/Grb2+,Ptentm2Mak/Ptentm2Mak,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Angptl4tm1Lex/Angptl4tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Angptl3tm1Akos/Angptl3tm1Akos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Grb2tm1Paw/Grb2+,Ptentm2Mak/Ptentm2Mak,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Angptl3tm1Akos/Angptl3tm1Akos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Angptl3tm1Akos/Angptl3tm1Akos,Angptl4tm1Akos/Angptl4tm1Akos
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Angptl4tm1Lex/Angptl4tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Angptl4tm1Lex/Angptl4+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0002725 abnormal vein morphology "malformation of the blood vessels that carry blood towards the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mc3rtm1Butl/Mc3rtm1Butl,Tg(Nes-cre)1Kln/0
Genetic Background: B6.Cg-Mc3rtm1Butl Tg(Nes-Cre)1Kln

 MP:0003070 increased vascular permeability "greater or faster ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mc3rtm1Butl/Mc3rtm1Butl,Tg(Nes-cre)1Kln/0
Genetic Background: B6.Cg-Mc3rtm1Butl Tg(Nes-Cre)1Kln

 MP:0003658 abnormal capillaries "malformation in the minute blood vessels that connect arterioles and venules" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96775]
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Allelic Composition: Mc3rtm1Butl/Mc3rtm1Butl,Tg(Nes-cre)1Kln/0
Genetic Background: B6.Cg-Mc3rtm1Butl Tg(Nes-Cre)1Kln

 MP:0003719 abnormal pericyte morphology "malformation in the connective tissue cells that occurs around capillaries or other small blood vessels " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mc3rtm1Butl/Mc3rtm1Butl,Tg(Nes-cre)1Kln/0
Genetic Background: B6.Cg-Mc3rtm1Butl Tg(Nes-Cre)1Kln

 MP:0005146 decreased circulating VLDL cholesterol level "less than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Grb2tm1Paw/Grb2+,Ptentm2Mak/Ptentm2Mak,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Angptl4tm1Lex/Angptl4tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Angptl3tm1Akos/Angptl3tm1Akos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Angptl3tm1Akos/Angptl3tm1Akos,Angptl4tm1Akos/Angptl4tm1Akos
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005232 abnormal mesenteric lymph node morphology "anomalous structure, development, or number of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Grb2tm1Paw/Grb2+,Ptentm2Mak/Ptentm2Mak,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Angptl4tm1Lex/Angptl4tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0005318 decreased triglyceride level "lower than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Grb2tm1Paw/Grb2+,Ptentm2Mak/Ptentm2Mak,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Angptl4tm1Lex/Angptl4tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Angptl4tm2Lex/Angptl4tm2Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
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Allelic Composition: Mc3rtm1Butl/Mc3rtm1Butl,Tg(Nes-cre)1Kln/0
Genetic Background: B6.Cg-Mc3rtm1Butl Tg(Nes-Cre)1Kln

 MP:0005666 abnormal adipose tissue physiology "functional anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Foxo3Gt(XAO26)Byg/Foxo3Gt(XAO26)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0008034 enhanced lipolysis "increase in the rate of the hydrolysis of fat into free fatty acids " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grb2tm1Paw/Grb2+,Ptentm2Mak/Ptentm2Mak,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Angptl4tm1Lex/Angptl4tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0009660 abnormal induced retinal neovascularization "any anomaly in the response to conditions which induce the pathological growth of vessels into the retina" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mc3rtm1Butl/Mc3rtm1Butl,Tg(Nes-cre)1Kln/0
Genetic Background: B6.Cg-Mc3rtm1Butl Tg(Nes-Cre)1Kln

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grb2tm1Paw/Grb2+,Ptentm2Mak/Ptentm2Mak,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Angptl4tm1Lex/Angptl4tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxo3Gt(XAO26)Byg/Foxo3Gt(XAO26)Byg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Angptl4tm1Jig/Angptl4+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0010097 abnormal retinal blood vessel morphology "any structural anomaly of the blood vessels supplying the retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mc3rtm1Butl/Mc3rtm1Butl,Tg(Nes-cre)1Kln/0
Genetic Background: B6.Cg-Mc3rtm1Butl Tg(Nes-Cre)1Kln

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Angptl3tm1Akos/Angptl3tm1Akos,Angptl4tm1Akos/Angptl4tm1Akos
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Mc3rtm1Butl/Mc3rtm1Butl,Tg(Nes-cre)1Kln/0
Genetic Background: B6.Cg-Mc3rtm1Butl Tg(Nes-Cre)1Kln

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Mc3rtm1Butl/Mc3rtm1Butl,Tg(Nes-cre)1Kln/0
Genetic Background: B6.Cg-Mc3rtm1Butl Tg(Nes-Cre)1Kln

 MP:0011578 increased lipoprotein lipase activity "greater ability to catalyze the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate" [GO:0004465]
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Allelic Composition: Angptl3tm1Akos/Angptl3tm1Akos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0012080 chylous ascites "the extravasation of milky triglyceride-rich chyle into the peritoneal cavity; often a secondary symptom of neoplasms" [MGI:csmith]
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Allelic Composition: Grb2tm1Paw/Grb2+,Ptentm2Mak/Ptentm2Mak,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Angptl4tm1Lex/Angptl4tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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