ENSMUSG00000033327


Mus musculus

Features
Gene ID: ENSMUSG00000033327
  
Biological name :Tnxb
  
Synonyms : tenascin XB / Tnxb
  
Possible biological names infered from orthology : P22105
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: B1
Gene start: 34670535
Gene end: 34719815
  
Corresponding Affymetrix probe sets: 10444459 (MoGene1.0st)   1450798_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000084661
Ensembl peptide - ENSMUSP00000127487
NCBI entrez gene - 81877     See in Manteia.
MGI - MGI:1932137
RefSeq - XM_006525191
RefSeq - NM_031176
RefSeq - XM_006525188
RefSeq - XM_006525189
RefSeq - XM_006525190
RefSeq - XM_006525185
RefSeq - XM_006525186
RefSeq - XM_006525187
RefSeq Peptide - NP_112453
swissprot - O35452
swissprot - E9Q2T3
Ensembl - ENSMUSG00000033327
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tnxbaENSDARG00000001760Danio rerio
 ENSGALG00000041031Gallus gallus
 TNXBENSG00000168477Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tnc / Q80YX1 / tenascin C / P24821*ENSMUSG0000002836423
Tnn / Q80Z71 / Tenascin-N / Q9UQP3*ENSMUSG0000002672514
Tnr / Q8BYI9 / Tenascin-R / Q92752*ENSMUSG0000001582914
Fn1 / P11276 / Fibronectin Anastellin / P02751* / fibronectin 1*ENSMUSG0000002619311
Fga / E9PV24 / Fibrinogen alpha chain Fibrinopeptide A Fibrinogen alpha chain / P02671* / fibrinogen alpha chain*ENSMUSG000000280015
Fgb / Q8K0E8 / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain / P02675* / fibrinogen beta chain*ENSMUSG000000338314
Q9Z1P8 / Angptl4 / Angiopoietin-related protein 4 / Q9BY76* / angiopoietin like 4*ENSMUSG000000022893
Q9R182 / Angptl3 / Angiopoietin-related protein 3 ANGPTL3(17-224) / Q9Y5C1* / angiopoietin like 3*ENSMUSG000000285533
Fgl1 / fibrinogen like 1 / Q08830*ENSMUSG000000315943
Fgg / Q8VCM7 / Fibrinogen gamma chain / P02679*ENSMUSG000000338603


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR002181  Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
 IPR003961  Fibronectin type III
 IPR013032  EGF-like, conserved site
 IPR013111  EGF-like domain, extracellular
 IPR013783  Immunoglobulin-like fold
 IPR014715  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
 IPR014716  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
 IPR020837  Fibrinogen, conserved site
 IPR033081  Tenascin-X
 IPR036056  Fibrinogen-like, C-terminal
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IMP
 biological_processGO:0006631 fatty acid metabolic process IMP
 biological_processGO:0006641 triglyceride metabolic process IMP
 biological_processGO:0007160 cell-matrix adhesion IMP
 biological_processGO:0030198 extracellular matrix organization IMP
 biological_processGO:0030199 collagen fibril organization IMP
 biological_processGO:0032963 collagen metabolic process ISO
 biological_processGO:0043506 regulation of JUN kinase activity IMP
 biological_processGO:0048251 elastic fiber assembly ISO
 biological_processGO:0098609 cell-cell adhesion IMP
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005583 fibrillar collagen trimer ISO
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0005622 intracellular ISO
 cellular_componentGO:0031012 extracellular matrix ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005518 collagen binding IDA
 molecular_functionGO:0008201 heparin binding IDA


Pathways (from Reactome)
Pathway description
ECM proteoglycans


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

 MP:0002166 altered tumor susceptibility/resistance "greater than or less than the average number of tumors, usually a specific type, arising in a given strain when compared to controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Plscr1tm1Lex/Plscr1tm1Lex,Plscr3tm1Sims/Plscr3tm1Sims
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005275 abnormal skin tensile strength "change from the normal maximum tension the skin can withstand without tearing" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84062]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005566 decreased blood urea nitrogen level "low circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

 MP:0008438 abnormal cutaneous collagen fibril morphology "any structural anomaly of the connective tissue bundles in the extracellular matrix of skin tissue that are composed of collagen, and play a role in skin strength and elasticity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plscr1tm1Lex/Plscr1tm1Lex,Plscr3tm1Sims/Plscr3tm1Sims
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plscr1tm1Lex/Plscr1tm1Lex,Plscr3tm1Sims/Plscr3tm1Sims
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000033327 Tnxb / tenascin XB / P22105*  / complex






 

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