ENSMUSG00000026193


Mus musculus

Features
Gene ID: ENSMUSG00000026193
  
Biological name :Fn1
  
Synonyms : Fibronectin Anastellin / Fn1 / P11276
  
Possible biological names infered from orthology : fibronectin 1 / P02751
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: C3
Gene start: 71585520
Gene end: 71653200
  
Corresponding Affymetrix probe sets: 10355403 (MoGene1.0st)   1426642_at (Mouse Genome 430 2.0 Array)   1437218_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000140315
Ensembl peptide - ENSMUSP00000140153
Ensembl peptide - ENSMUSP00000140372
Ensembl peptide - ENSMUSP00000141193
Ensembl peptide - ENSMUSP00000141123
Ensembl peptide - ENSMUSP00000140975
Ensembl peptide - ENSMUSP00000140955
Ensembl peptide - ENSMUSP00000140907
Ensembl peptide - ENSMUSP00000140816
Ensembl peptide - ENSMUSP00000140471
Ensembl peptide - ENSMUSP00000054499
Ensembl peptide - ENSMUSP00000139702
NCBI entrez gene - 14268     See in Manteia.
MGI - MGI:95566
RefSeq - XM_017315848
RefSeq - NM_001276408
RefSeq - NM_001276409
RefSeq - NM_001276410
RefSeq - NM_001276411
RefSeq - NM_001276412
RefSeq - NM_001276413
RefSeq - NM_010233
RefSeq - XM_006495697
RefSeq - XM_006495699
RefSeq - XM_006495700
RefSeq - XM_017315775
RefSeq - XM_017315837
RefSeq Peptide - NP_001263338
RefSeq Peptide - NP_001263339
RefSeq Peptide - NP_001263340
RefSeq Peptide - NP_001263341
RefSeq Peptide - NP_001263342
RefSeq Peptide - NP_034363
RefSeq Peptide - NP_001263337
swissprot - A0A087WS99
swissprot - A0A087WS56
swissprot - A0A087WR50
swissprot - A0A087WQW8
swissprot - Q3UHL6
swissprot - P11276
swissprot - Q4KL80
swissprot - A0A087WQE0
swissprot - B9EHT6
swissprot - B7ZNJ1
swissprot - A0A087WSU6
swissprot - A0A087WSN6
Ensembl - ENSMUSG00000026193
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fn1aENSDARG00000019815Danio rerio
 fn1bENSDARG00000006526Danio rerio
 FN1ENSGALG00000003578Gallus gallus
 FN1ENSG00000115414Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tnc / Q80YX1 / tenascin C / P24821*ENSMUSG0000002836416
Tnxb / tenascin XB / P22105*ENSMUSG0000003332714
Tnr / Q8BYI9 / Tenascin-R / Q92752*ENSMUSG0000001582913
Tnn / Q80Z71 / Tenascin-N / Q9UQP3*ENSMUSG0000002672513
Fgb / Q8K0E8 / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain / P02675* / fibrinogen beta chain*ENSMUSG000000338314
Fga / E9PV24 / Fibrinogen alpha chain Fibrinopeptide A Fibrinogen alpha chain / P02671* / fibrinogen alpha chain*ENSMUSG000000280014
Fgg / Q8VCM7 / Fibrinogen gamma chain / P02679*ENSMUSG000000338603
Q9Z1P8 / Angptl4 / Angiopoietin-related protein 4 / Q9BY76* / angiopoietin like 4*ENSMUSG000000022893
Q9R182 / Angptl3 / Angiopoietin-related protein 3 ANGPTL3(17-224) / Q9Y5C1* / angiopoietin like 3*ENSMUSG000000285533
Fgl1 / fibrinogen like 1 / Q08830*ENSMUSG000000315942


Protein motifs (from Interpro)
Interpro ID Name
 IPR000083  Fibronectin, type I
 IPR000562  Fibronectin type II domain
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR013806  Kringle-like fold
 IPR036116  Fibronectin type III superfamily
 IPR036943  Fibronectin type II domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001932 regulation of protein phosphorylation IEA
 biological_processGO:0006953 acute-phase response IEA
 biological_processGO:0007044 cell-substrate junction assembly IDA
 biological_processGO:0007155 cell adhesion IDA
 biological_processGO:0007160 cell-matrix adhesion IDA
 biological_processGO:0007161 calcium-independent cell-matrix adhesion IDA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008360 regulation of cell shape IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010952 positive regulation of peptidase activity IEA
 biological_processGO:0018149 peptide cross-linking IEA
 biological_processGO:0033622 integrin activation IEA
 biological_processGO:0034446 substrate adhesion-dependent cell spreading IEA
 biological_processGO:0035987 endodermal cell differentiation IEA
 biological_processGO:0042060 wound healing IMP
 biological_processGO:0045773 positive regulation of axon extension IDA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IEA
 biological_processGO:0051702 interaction with symbiont IEA
 biological_processGO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction IEA
 biological_processGO:0070372 regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:1904237 positive regulation of substrate-dependent cell migration, cell attachment to substrate IEA
 biological_processGO:2001202 negative regulation of transforming growth factor-beta secretion IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005577 fibrinogen complex IEA
 cellular_componentGO:0005604 basement membrane IDA
 cellular_componentGO:0005605 basal lamina IDA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005793 endoplasmic reticulum-Golgi intermediate compartment IEA
 cellular_componentGO:0016324 apical plasma membrane IDA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0070062 extracellular exosome IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0016504 peptidase activator activity IDA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0051087 chaperone binding IEA
 molecular_functionGO:0097718 disordered domain specific binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Degradation of the extracellular matrix
Extracellular matrix organization
Fibronectin matrix formation
Cell surface interactions at the vascular wall
Molecules associated with elastic fibres
Integrin cell surface interactions
Syndecan interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
Integrin alphaIIb beta3 signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
MAP2K and MAPK activation
MET activates PTK2 signaling
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
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Allelic Composition: Gbatm1Karl/Gbatm1Karl,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ets2tm3Rgo/Ets2+,Meox2tm1(cre)Sor/?,Tg(MMTV-cre)7Mul/?
Genetic Background: involves: 129S4/SvJaeSor * FVB/N

Allelic Composition: Fn1tm3Hyn/Fn1tm3Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0000292 distended pericardial sacs "stretched outer parietal layer of the pericardium" [J:25248]
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Allelic Composition: Fn1tm4Hyn/Fn1tm4Hyn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000297 abnormal endocardial cushion morphology "malformation of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal; these mounds eventually fuse to form the valves between the right and left atrioventricular orifices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fn1tm4Hyn/Fn1tm4Hyn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
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Allelic Composition: Fn1tm2.1Ref/Fn1tm2.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ticam2M1Btlr/Ticam2+
Genetic Background: C57BL/6J-Ticam2M1Btlr

 MP:0000932 absent notochord "missing axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0001209 spontaneous skin ulceration "unpredictable appearance of skin lesions, usually with inflammation" [J:65302]
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Allelic Composition: Fn1tm2Feb/Fn1tm2Feb
Genetic Background: involves: 129X1/SvJ

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
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Allelic Composition: Fn1tm2Feb/Fn1tm2Feb
Genetic Background: involves: 129X1/SvJ

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Fn1tm4Hyn/Fn1tm4Hyn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001622 abnormal vasculogenesis "aberrant process of the initial establishment of the vascular network " [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0001680 abnormal mesoderm development "failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0001689 incomplete somite formation "arrest of differentiation or patterning of the somites" [J:62882]
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Allelic Composition: Fn1tm2.1Ref/Fn1tm2.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001695 abnormal gastrulation "anomalous development and invagination of the embryonic germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lamc1Gt(Ex183)Byg/Lamc1Gt(Ex183)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
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Allelic Composition: Fn1tm2.1Ref/Fn1tm2.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

Allelic Composition: Fn1tm2Hyn/Fn1tm2Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Fn1tm3Hyn/Fn1tm3Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Fn1tm4Hyn/Fn1tm4Hyn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001719 absent vitelline blood vessels "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

Allelic Composition: Fn1tm2Hyn/Fn1tm2Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Fn1tm3Hyn/Fn1tm3Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Fn1tm4Hyn/Fn1tm4Hyn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001721 absent blood islands "missing pools of blood in the yolk sac" [J:12623]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0001723 disorganized vascular plexus 
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Allelic Composition: Fn1tm4Hyn/Fn1tm4Hyn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001792 impaired wound healing "reduced ability or inability to self-repair and close wounds" [J:65302, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fn1tm2Feb/Fn1tm2Feb
Genetic Background: involves: 129X1/SvJ

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Fn1tm4Hyn/Fn1tm4Hyn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002038 carcinoma "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: T41H/T41H
Genetic Background: involves: 101/Rl * BALB/cOlaHsd * C3H/Rl

Allelic Composition: Fn1tm1Ksek/Fn1tm1Ksek,Tg(RIP1-Tag)2Dh/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc45a2uw/Slc45a2uw
Genetic Background: C57BL/6J-Slc45a2uw/J

Allelic Composition: Fn1tm2Feb/Fn1tm2Feb
Genetic Background: involves: 129X1/SvJ

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

Allelic Composition: Fn1tm2.1Ref/Fn1tm2.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn1atm2(HBx)Xya/Cdkn1atm2(HBx)Xya
Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss)

Allelic Composition: Fn1tm1Ref/Fn1tm1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Fn1tm2Bwg/Fn1tm2Bwg
Genetic Background: involves: 129S4/SvJae

 MP:0002825 abnormal notochord "malformation or absence of the axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Fn1tm2Hyn/Fn1tm2Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Fn1tm3Hyn/Fn1tm3Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0003076 increased susceptibility to ischemic brain injury "increased lesion size following loss of circulation in a region of the brain; may be induced or spontaneous" [J:90111, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Fn1tm1Ref/Fn1tm1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Fn1tm1Ref/Fn1tm1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: Fn1tm2.1Ref/Fn1tm2.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003231 abnormal placental vasculature "malformation in the vessels of the placenta" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
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Allelic Composition: Fn1tm4Hyn/Fn1tm4Hyn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003400 kinked neural tube "twists or kinks in the embryonic neural tube" [J:66514, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

Allelic Composition: Fn1tm2Hyn/Fn1tm2Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Fn1tm3Hyn/Fn1tm3Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Fn1tm4Hyn/Fn1tm4Hyn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Fn1tm2.1Ref/Fn1tm2.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003974 abnormal endocardium morphology "malformation of the thin serous membrane, primarily composed of endothelial tissue, that lines the interior of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

Allelic Composition: Fn1tm2Hyn/Fn1tm2Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Fn1tm3Hyn/Fn1tm3Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0004076 abnormal vitelline vascular remodelling "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Fn1tm4Hyn/Fn1tm4Hyn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004180 failure of initiation of embryo turning "failure to begin the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0004573 absent limb buds "missing the mesenchymal outgrowth on the lateral trunk of the embryo that develops into the limbs" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Fn1tm2.1Ref/Fn1tm2.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004787 abnormal dorsal aorta morphology "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0005029 abnormal amnion "malformed innermost layer of the extraembryonic membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

Allelic Composition: Fn1tm2Hyn/Fn1tm2Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Fn1tm3Hyn/Fn1tm3Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0005048 thrombosis "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fn1tm1Ref/Fn1tm1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005146 decreased circulating VLDL cholesterol level "less than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn1atm2(HBx)Xya/Cdkn1atm2(HBx)Xya
Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss)

 MP:0005164 abnormal response to injury "anomaly in the body s reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ticam2M1Btlr/Ticam2+
Genetic Background: C57BL/6J-Ticam2M1Btlr

 MP:0005278 abnormal cholesterol homeostasis "anomaly in the state of equilibrium in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:71350]
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Allelic Composition: Cdkn1atm2(HBx)Xya/Cdkn1atm2(HBx)Xya
Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss)

 MP:0005341 decreased susceptibility to atherosclerosis "less likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn1atm2(HBx)Xya/Cdkn1atm2(HBx)Xya
Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss)

 MP:0005592 abnormal vascular smooth muscle morphology "structural anomaly of the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fn1tm4Hyn/Fn1tm4Hyn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0006060 increased cerebral infarction size "increased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Fn1tm1Ref/Fn1tm1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006126 abnormal outflow tract development "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Fn1tm4Hyn/Fn1tm4Hyn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0006386 absent somites "missing all somites" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

Allelic Composition: Fn1tm2Hyn/Fn1tm2Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Fn1tm3Hyn/Fn1tm3Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0008469 abnormal protein level "anomaly in the amount of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc45a2uw/Slc45a2uw
Genetic Background: C57BL/6J-Slc45a2uw/J

 MP:0008530 abnormal rostral-caudal patterning of the somites "anomaly in the developmental pattern of the somites along the axis that runs from the head to the caudal region of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fn1tm2.1Ref/Fn1tm2.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009382 abnormal cardiac jelly morphology "any structural anomaly of the gelatinous noncellular material between the endothelial lining and the myocardial layer of the developing heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0009657 failure of chorioallantoic fusion "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0010117 abnormal lateral plate mesoderm "anomaly of the portion of the middle of the three primary germ layers of the embryo that resides on the periphery of the embryo, is continuous with the extra-embryonic mesoderm, splits into two layers enclosing the intra-embryonic coelom, and gives rise to body wall structures" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0010656 thick myocardium "increased thickness of the heart muscle layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Fn1tm4Hyn/Fn1tm4Hyn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Lamc1Gt(Ex183)Byg/Lamc1Gt(Ex183)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

Allelic Composition: Fn1tm2Hyn/Fn1tm2Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Fn1tm3Hyn/Fn1tm3Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Fn1tm2.1Ref/Fn1tm2.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Fn1tm4Hyn/Fn1tm4Hyn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Fn1tm4Hyn/Fn1tm4Hyn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: T41H/T41H
Genetic Background: involves: 101/Rl * BALB/cOlaHsd * C3H/Rl

 MP:0012173 short rostral-caudal axis "length reduction or truncation of the axis that runs from the head to the tail of the body" [MGI:anna]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

Allelic Composition: Fn1tm2Hyn/Fn1tm2Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Fn1tm3Hyn/Fn1tm3Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Fn1tm2.1Ref/Fn1tm2.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0012277 increased tail bud apoptosis "increased number of cells undergoing programmed cell death in the primordial region of the embryo that arises to form the tail of the adult" [MGI:anna]
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Allelic Composition: Fn1tm2.1Ref/Fn1tm2.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0013200 head mesenchyme hypoplasia "underdevelopment or reduced size of the head mesenchyme, usually due to a reduced cell number" [MGI:anna]
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Allelic Composition: Fn1tm2Hyn/Fn1tm2Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Fn1tm3Hyn/Fn1tm3Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0013258 abnormal extracellular matrix morphology "any structural anomaly of the structure lying external to one or more cells, which provides structural support for cells or tissues; in mammals, the extracellular matrix is completely external to the cell " [GO:0031012]
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Allelic Composition: T41H/T41H
Genetic Background: involves: 101/Rl * BALB/cOlaHsd * C3H/Rl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / reaction / complex
 ENSMUSG00000020689 Itgb3 / O54890 / Integrin beta-3 / P05106* / AC068234.1* / integrin subunit beta 3*  / complex / reaction
 ENSMUSG00000028364 Tnc / Q80YX1 / tenascin C / P24821*  / complex / reaction
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction / complex
 ENSMUSG00000032312 Csk / P41241 / Tyrosine-protein kinase CSK / P41240* / C-terminal Src kinase*  / complex / reaction
 ENSMUSG00000064080 Fbln2 / P37889 / Fibulin-2 / P98095*  / complex / reaction
 ENSMUSG00000027540 Ptpn1 / P35821 / protein tyrosine phosphatase, non-receptor type 1 / P18031*  / reaction
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / complex / reaction
 ENSMUSG00000021457 Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*  / complex / reaction
 ENSMUSG00000006369 Fbln1 / Q08879 / Mus musculus fibulin 1 (Fbln1), transcript variant 2, mRNA. / P23142* / fibulin 1*  / complex / reaction
 ENSMUSG00000068798 Rap1a / P62835 / RAS-related protein 1a / P62834* / RAP1A, member of RAS oncogene family*  / reaction / complex
 ENSMUSG00000031955 Bcar1 / Q61140 / Breast cancer anti-estrogen resistance protein 1 / P56945* / BCAR1, Cas family scaffolding protein*  / reaction / complex
 ENSMUSG00000025809 Itgb1 / P09055 / Integrin beta-1 / P05556* / integrin subunit beta 1*  / complex / reaction
 ENSMUSG00000000555 Itga5 / P11688 / Integrin alpha-5 Integrin alpha-5 heavy chain Integrin alpha-5 light chain / P08648* / integrin subunit alpha 5*  / complex / reaction
 ENSMUSG00000017776 Crk / Q64010 / Adapter molecule crk / P46108* / CRK proto-oncogene, adaptor protein*  / reaction / complex
 ENSMUSG00000021823 Vcl / Q64727 / vinculin / P18206*  / complex
 ENSMUSG00000028465 Tln1 / P26039 / talin 1 / Q9Y490*  / reaction / complex
 ENSMUSG00000026193 Fn1 / P11276 / Fibronectin Anastellin / P02751* / fibronectin 1*  / - / complex / reaction
 ENSMUSG00000034664 Itga2b / Q9QUM0 / integrin alpha 2b / P08514* / integrin subunit alpha 2b*  / reaction / complex
 ENSMUSG00000022607 Ptk2 / P34152 / PTK2 protein tyrosine kinase 2 / Q05397* / protein tyrosine kinase 2*  / complex / reaction
 ENSMUSG00000026786 Q8R5A3 / Apbb1ip / amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein / Q7Z5R6* / amyloid beta precursor protein binding family B member 1 interacting protein*  / complex / reaction
 ENSMUSG00000052681 Rap1b / Q99JI6 / RAS related protein 1b / P61224* / RAP1B, member of RAS oncogene family*  / reaction / complex
 ENSMUSG00000015829 Tnr / Q8BYI9 / Tenascin-R / Q92752*  / reaction / complex






 

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