ENSGALG00000003578


Gallus gallus

Features
Gene ID: ENSGALG00000003578
  
Biological name :FN1
  
Synonyms : fibronectin 1 / FN1
  
Possible biological names infered from orthology : Fibronectin Anastellin / P02751 / P11276
  
Species: Gallus gallus
  
Chr. number: 7
Strand: -1
Band:
Gene start: 4390375
Gene end: 4439659
  
Corresponding Affymetrix probe sets: Gga.10439.1.S1_at (Chicken Array)   Gga.13487.1.A1_at (Chicken Array)   Gga.3994.1.A1_s_at (Chicken Array)   Gga.9293.1.S1_at (Chicken Array)   Gga.9772.1.S1_at (Chicken Array)   Gga.9772.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000043859
Ensembl peptide - ENSGALP00000005653
Ensembl peptide - ENSGALP00000005654
NCBI entrez gene - 396133     See in Manteia.
RefSeq - XM_015289133
RefSeq - XM_015289128
RefSeq - XM_015289129
RefSeq - XM_015289131
RefSeq - XM_015289132
RefSeq - NM_001198712
RefSeq Peptide - NP_001185641
swissprot - F1NJT3
swissprot - F1NJT4
swissprot - A0A1D5NU50
Ensembl - ENSGALG00000003578
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fn1aENSDARG00000019815Danio rerio
 fn1bENSDARG00000006526Danio rerio
 FN1ENSG00000115414Homo sapiens
 Fn1ENSMUSG00000026193Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TNC / tenascin C / P24821* / Q80YX1*ENSGALG0000003999016
TNR / tenascin-R precursor / Q8BYI9* / Q92752* / tenascin R*ENSGALG0000000452612
TNN / tenascin N / Q80Z71* / Q9UQP3*ENSGALG000000045389
TNXB* / P22105* / tenascin XB*ENSGALG000000410317
FGA / fibrinogen alpha chain isoform 1 precursor / E9PV24* / P02671* / fibrinogen alpha chain* / Fibrinogen alpha chain Fibrinopeptide A Fibrinogen alpha chain*ENSGALG000000092664
ANGPTL4 / angiopoietin like 4 / Q9BY76* / Q9Z1P8* / Angiopoietin-related protein 4 *ENSGALG000000006193
ANGPTL5 / Q86XS5* / angiopoietin like 5*ENSGALG000000171913
ANGPTL3 / angiopoietin-related protein 3 precursor / Q9R182* / Q9Y5C1* / angiopoietin like 3* / Angiopoietin-related protein 3 ANGPTL3(17-224)*ENSGALG000000109783
FGG / fibrinogen gamma chain / P02679* / Q8VCM7*ENSGALG000000092683
FGB / fibrinogen beta chain / P02675* / Q8K0E8* / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain*ENSGALG000000092623
ANGPT1L / angiopoietin-related protein 1-like precursor ENSGALG000000415022
FGL1 / fibrinogen like 1 / Q08830*ENSGALG000000136062
ENSGALG000000428192
ENSGALG000000418332
ENSGALG000000170292
ENSGALG000000464822
ENSGALG000000333142
ENSGALG000000452382
ENSGALG000000275202


Protein motifs (from Interpro)
Interpro ID Name
 IPR000083  Fibronectin, type I
 IPR000562  Fibronectin type II domain
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR013806  Kringle-like fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001932 regulation of protein phosphorylation IEA
 biological_processGO:0006929 substrate-dependent cell migration IMP
 biological_processGO:0007044 cell-substrate junction assembly IEA
 biological_processGO:0007155 cell adhesion IDA
 biological_processGO:0007160 cell-matrix adhesion IEA
 biological_processGO:0007161 calcium-independent cell-matrix adhesion IEA
 biological_processGO:0008283 cell proliferation IDA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010952 positive regulation of peptidase activity IEA
 biological_processGO:0018149 peptide cross-linking IEA
 biological_processGO:0031589 cell-substrate adhesion IMP
 biological_processGO:0033622 integrin activation IEA
 biological_processGO:0034446 substrate adhesion-dependent cell spreading IEA
 biological_processGO:0035987 endodermal cell differentiation IEA
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0045176 apical protein localization IDA
 biological_processGO:0045773 positive regulation of axon extension IEA
 biological_processGO:0048041 focal adhesion assembly IDA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IEA
 biological_processGO:0051702 interaction with symbiont IEA
 biological_processGO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction IEA
 biological_processGO:0060974 cell migration involved in heart formation IMP
 biological_processGO:0070372 regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0090245 axis elongation involved in somitogenesis IDA
 biological_processGO:1904237 positive regulation of substrate-dependent cell migration, cell attachment to substrate IEA
 biological_processGO:2001202 negative regulation of transforming growth factor-beta secretion IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005577 fibrinogen complex IEA
 cellular_componentGO:0005604 basement membrane IDA
 cellular_componentGO:0005605 basal lamina IEA
 cellular_componentGO:0005614 interstitial matrix IDA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005623 cell IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005793 endoplasmic reticulum-Golgi intermediate compartment IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0045178 basal part of cell IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0070062 extracellular exosome IEA
 cellular_componentGO:0099512 supramolecular fiber IDA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0016504 peptidase activator activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0051087 chaperone binding IEA
 molecular_functionGO:0097718 disordered domain specific binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Degradation of the extracellular matrix
Extracellular matrix organization
Fibronectin matrix formation
Cell surface interactions at the vascular wall
Molecules associated with elastic fibres
Integrin cell surface interactions
Syndecan interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
Integrin alphaIIb beta3 signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
MAP2K and MAPK activation
MET activates PTK2 signaling
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000379 ITGB3 / P05106* / O54890* / AC068234.1* / Integrin beta-3 * / integrin subunit beta 3*  / reaction / complex
 ENSGALG00000001476 RAP1A / RAP1A, member of RAS oncogene family / P62834* / P62835* / RAS-related protein 1a*  / reaction / complex
 ENSGALG00000002548 TLN1 / talin-1 / P26039* / Q9Y490*  / reaction / complex
 ENSGALG00000003855 SRC / P00523 / Proto-oncogene tyrosine-protein kinase Src / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction / complex
 ENSGALG00000039450 SOS1 / SOS Ras/Rac guanine nucleotide exchange factor 1 / Q07889* / Q62245* / Son of sevenless homolog 1 *  / complex / reaction
 ENSGALG00000015216 SYK / F1N9Y5 / Tyrosine-protein kinase SYK / P48025* / P43405* / spleen tyrosine kinase* / spleen associated tyrosine kinase*  / reaction / complex
 ENSGALG00000042895 BCAR1 / BCAR1, Cas family scaffolding protein / P56945* / Q61140* / Breast cancer anti-estrogen resistance protein 1 *  / complex / reaction
 ENSGALG00000007145 ITGB1 / integrin subunit beta 1 / P05556* / P09055* / Integrin beta-1 *  / reaction / complex
 ENSGALG00000003578 FN1 / fibronectin 1 / P02751* / P11276* / Fibronectin Anastellin*  / reaction / - / complex
 ENSGALG00000005079 VCL / P12003 / Vinculin / P18206* / Q64727*  / complex
 ENSGALG00000031270 CSK / tyrosine-protein kinase CSK / P41240* / P41241* / C-terminal Src kinase*  / reaction / complex
 ENSGALG00000002656 CRK / Q04929 / Adapter molecule crk / P46108* / Q64010* / CRK proto-oncogene, adaptor protein*  / complex / reaction
 ENSGALG00000031741 PTK2 / Q00944 / Focal adhesion kinase 1 / P34152* / Q05397* / protein tyrosine kinase 2* / PTK2 protein tyrosine kinase 2*  / complex / reaction
 ENSGALG00000008010 PTPN1 / tyrosine-protein phosphatase non-receptor type 1 / P18031* / P35821* / protein tyrosine phosphatase, non-receptor type 1*  / reaction
 ENSGALG00000007579 APBB1IP / amyloid beta precursor protein binding family B member 1 interacting protein / Q7Z5R6* / Q8R5A3* / amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein*  / reaction / complex
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / complex / reaction
 ENSGALG00000014233 FBLN1 / fibulin-1 precursor / P23142* / Q08879* / fibulin 1* / Mus musculus fibulin 1 (Fbln1), transcript variant 2, mRNA.*  / reaction / complex
 ENSGALG00000009927 RAP1B / Q5ZHX1 / Ras-related protein Rap-1b / Q99JI6* / P61224* / RAS related protein 1b* / RAP1B, member of RAS oncogene family*  / complex / reaction
 ENSGALG00000039990 TNC / tenascin C / P24821* / Q80YX1*  / reaction / complex






 

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