ENSGALG00000005079


Gallus gallus

Features
Gene ID: ENSGALG00000005079
  
Biological name :VCL
  
Synonyms : P12003 / VCL / Vinculin
  
Possible biological names infered from orthology : P18206 / Q64727
  
Species: Gallus gallus
  
Chr. number: 6
Strand: -1
Band:
Gene start: 15394778
Gene end: 15448303
  
Corresponding Affymetrix probe sets: Gga.698.1.S1_at (Chicken Array)   Gga.698.1.S2_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000008131
Ensembl peptide - ENSGALP00000048583
NCBI entrez gene - 396422     See in Manteia.
RefSeq - XM_015288203
RefSeq - NM_205441
RefSeq - XM_015288200
RefSeq - XM_015288201
RefSeq - XM_015288202
RefSeq Peptide - NP_990772
swissprot - P12003
swissprot - F1NYY0
Ensembl - ENSGALG00000005079
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vclaENSDARG00000098695Danio rerio
 vclaENSDARG00000044968Danio rerio
 VCLENSG00000035403Homo sapiens
 VclENSMUSG00000021823Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CTNNA1 / catenin alpha 1 / P26231* / P35221*ENSGALG0000000244719
CTNNA3 / catenin alpha 3 / Q65CL1* / Q9UI47*ENSGALG0000000284517
CTNNA2 / catenin alpha-2 / P26232* / Q61301* / Mus musculus catenin (cadherin associated protein), alpha 2 (Ctnna2), transcript variant 4, mRNA.*ENSGALG0000002785312
CTNNAL1 / catenin alpha like 1 / O88327* / Q9UBT7* / Alpha-catulin *ENSGALG0000001320710
CTNNA2* / P26232* / Q61301* / catenin alpha 2* / Mus musculus catenin (cadherin associated protein), alpha 2 (Ctnna2), transcript variant 4, mRNA.*ENSGALG000000159667


Protein motifs (from Interpro)
Interpro ID Name
 IPR000633  Vinculin, conserved site
 IPR006077  Vinculin/alpha-catenin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002009 morphogenesis of an epithelium IDA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0030032 lamellipodium assembly ISS
 biological_processGO:0030334 regulation of cell migration ISS
 biological_processGO:0034333 adherens junction assembly IDA
 biological_processGO:0090136 epithelial cell-cell adhesion IDA
 cellular_componentGO:0001725 stress fiber IDA
 cellular_componentGO:0005623 cell ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005743 mitochondrial inner membrane IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0005903 brush border ISS
 cellular_componentGO:0005911 cell-cell junction ISS
 cellular_componentGO:0005912 adherens junction ISS
 cellular_componentGO:0005915 zonula adherens ISS
 cellular_componentGO:0005925 focal adhesion ISS
 cellular_componentGO:0005927 muscle tendon junction IDA
 cellular_componentGO:0015629 actin cytoskeleton IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030018 Z disc IDA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031594 neuromuscular junction IDA
 cellular_componentGO:0042383 sarcolemma ISS
 cellular_componentGO:0043034 costamere ISS
 cellular_componentGO:0090636 outer dense plaque of desmosome ISS
 cellular_componentGO:0090637 inner dense plaque of desmosome ISS
 cellular_componentGO:0098723 skeletal muscle myofibril IDA
 cellular_componentGO:1990357 terminal web ISS
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding IDA
 molecular_functionGO:0017166 vinculin binding IDA
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0045294 alpha-catenin binding IDA
 molecular_functionGO:0045296 cadherin binding IPI
 molecular_functionGO:0051015 actin filament binding IEA
 molecular_functionGO:0051371 muscle alpha-actinin binding IMP
 molecular_functionGO:0051393 alpha-actinin binding IDA
 molecular_functionGO:0097110 scaffold protein binding IPI


Pathways (from Reactome)
Pathway description
Platelet degranulation
Smooth Muscle Contraction
MAP2K and MAPK activation
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000379 ITGB3 / P05106* / O54890* / AC068234.1* / Integrin beta-3 * / integrin subunit beta 3*  / complex
 ENSGALG00000001476 RAP1A / RAP1A, member of RAS oncogene family / P62834* / P62835* / RAS-related protein 1a*  / complex
 ENSGALG00000002548 TLN1 / talin-1 / P26039* / Q9Y490*  / complex
 ENSGALG00000003855 SRC / P00523 / Proto-oncogene tyrosine-protein kinase Src / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex
 ENSGALG00000003578 FN1 / fibronectin 1 / P02751* / P11276* / Fibronectin Anastellin*  / complex
 ENSGALG00000007579 APBB1IP / amyloid beta precursor protein binding family B member 1 interacting protein / Q7Z5R6* / Q8R5A3* / amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein*  / complex
 ENSGALG00000009268 FGG / fibrinogen gamma chain / P02679* / Q8VCM7*  / complex
 ENSGALG00000009927 RAP1B / Q5ZHX1 / Ras-related protein Rap-1b / Q99JI6* / P61224* / RAS related protein 1b* / RAP1B, member of RAS oncogene family*  / complex
 ENSGALG00000031270 CSK / tyrosine-protein kinase CSK / P41240* / P41241* / C-terminal Src kinase*  / complex
 ENSGALG00000009262 FGB / fibrinogen beta chain / P02675* / Q8K0E8* / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain*  / complex






 

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