ENSGALG00000009262


Gallus gallus

Features
Gene ID: ENSGALG00000009262
  
Biological name :FGB
  
Synonyms : FGB / fibrinogen beta chain
  
Possible biological names infered from orthology : Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain / P02675 / Q8K0E8
  
Species: Gallus gallus
  
Chr. number: 4
Strand: 1
Band:
Gene start: 20472456
Gene end: 20478595
  
Corresponding Affymetrix probe sets: Gga.4557.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000038105
NCBI entrez gene - 373926     See in Manteia.
RefSeq - NM_001167683
RefSeq Peptide - NP_001161155
swissprot - F1NUL9
Ensembl - ENSGALG00000009262
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fgbENSDARG00000008969Danio rerio
 FGBENSG00000171564Homo sapiens
 FgbENSMUSG00000033831Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FGA / fibrinogen alpha chain isoform 1 precursor / E9PV24* / P02671* / fibrinogen alpha chain* / Fibrinogen alpha chain Fibrinopeptide A Fibrinogen alpha chain*ENSGALG0000000926629
FGG / fibrinogen gamma chain / P02679* / Q8VCM7*ENSGALG0000000926826
TNN / tenascin N / Q80Z71* / Q9UQP3*ENSGALG0000000453823
ENSGALG0000001702922
TNR / tenascin-R precursor / Q8BYI9* / Q92752* / tenascin R*ENSGALG0000000452622
FGL1 / fibrinogen like 1 / Q08830*ENSGALG0000001360621
ANGPTL4 / angiopoietin like 4 / Q9BY76* / Q9Z1P8* / Angiopoietin-related protein 4 *ENSGALG0000000061921
ANGPTL3 / angiopoietin-related protein 3 precursor / Q9R182* / Q9Y5C1* / angiopoietin like 3* / Angiopoietin-related protein 3 ANGPTL3(17-224)*ENSGALG0000001097821
TNC / tenascin C / P24821* / Q80YX1*ENSGALG0000003999020
ANGPTL5 / Q86XS5* / angiopoietin like 5*ENSGALG0000001719120
TNXB* / P22105* / tenascin XB*ENSGALG0000004103117
ENSGALG0000002752016
ENSGALG0000004523816
FN1 / fibronectin 1 / P02751* / P11276* / Fibronectin Anastellin*ENSGALG0000000357816
ENSGALG0000004281915
ENSGALG0000003331415
ANGPT1L / angiopoietin-related protein 1-like precursor ENSGALG0000004150214
ENSGALG0000004648214
ENSGALG0000004183314


Protein motifs (from Interpro)
Interpro ID Name
 IPR002181  Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
 IPR012290  Fibrinogen, alpha/beta/gamma chain, coiled coil domain
 IPR014715  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
 IPR014716  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
 IPR020837  Fibrinogen, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007160 cell-matrix adhesion IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007596 blood coagulation IEA
 biological_processGO:0030168 platelet activation IEA
 biological_processGO:0031639 plasminogen activation IEA
 biological_processGO:0034116 positive regulation of heterotypic cell-cell adhesion IEA
 biological_processGO:0034622 cellular protein-containing complex assembly IEA
 biological_processGO:0042730 fibrinolysis IEA
 biological_processGO:0043152 induction of bacterial agglutination IEA
 biological_processGO:0045907 positive regulation of vasoconstriction IEA
 biological_processGO:0045921 positive regulation of exocytosis IEA
 biological_processGO:0050714 positive regulation of protein secretion IEA
 biological_processGO:0051258 protein polymerization IEA
 biological_processGO:0051592 response to calcium ion IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070527 platelet aggregation IEA
 biological_processGO:0072378 blood coagulation, fibrin clot formation IEA
 biological_processGO:0090277 positive regulation of peptide hormone secretion IEA
 biological_processGO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
 biological_processGO:2000352 negative regulation of endothelial cell apoptotic process IEA
 cellular_componentGO:0005577 fibrinogen complex IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0031091 platelet alpha granule IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0030674 protein binding, bridging IEA
 molecular_functionGO:0050839 cell adhesion molecule binding IEA
 molecular_functionGO:0051087 chaperone binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Common Pathway of Fibrin Clot Formation
Integrin cell surface interactions
Integrin alphaIIb beta3 signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
MAP2K and MAPK activation
Regulation of TLR by endogenous ligand


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000379 ITGB3 / P05106* / O54890* / AC068234.1* / Integrin beta-3 * / integrin subunit beta 3*  / reaction / complex
 ENSGALG00000001476 RAP1A / RAP1A, member of RAS oncogene family / P62834* / P62835* / RAS-related protein 1a*  / reaction / complex
 ENSGALG00000002548 TLN1 / talin-1 / P26039* / Q9Y490*  / complex / reaction
 ENSGALG00000003855 SRC / P00523 / Proto-oncogene tyrosine-protein kinase Src / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex / reaction
 ENSGALG00000008010 PTPN1 / tyrosine-protein phosphatase non-receptor type 1 / P18031* / P35821* / protein tyrosine phosphatase, non-receptor type 1*  / reaction
 ENSGALG00000007579 APBB1IP / amyloid beta precursor protein binding family B member 1 interacting protein / Q7Z5R6* / Q8R5A3* / amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein*  / reaction / complex
 ENSGALG00000008332 F2 / prothrombin precursor / P00734* / P19221* / coagulation factor II, thrombin* / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain*  / reaction
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / complex / reaction
 ENSGALG00000009268 FGG / fibrinogen gamma chain / P02679* / Q8VCM7*  / complex / reaction
 ENSGALG00000009927 RAP1B / Q5ZHX1 / Ras-related protein Rap-1b / Q99JI6* / P61224* / RAS related protein 1b* / RAP1B, member of RAS oncogene family*  / reaction / complex
 ENSGALG00000031270 CSK / tyrosine-protein kinase CSK / P41240* / P41241* / C-terminal Src kinase*  / complex / reaction
 ENSGALG00000005079 VCL / P12003 / Vinculin / P18206* / Q64727*  / complex
 ENSGALG00000032701 LY96 / lymphocyte antigen 96 / Q9JHF9* / Q9Y6Y9*  / reaction / complex
 ENSGALG00000042895 BCAR1 / BCAR1, Cas family scaffolding protein / P56945* / Q61140* / Breast cancer anti-estrogen resistance protein 1 *  / complex / reaction
 ENSGALG00000009262 FGB / fibrinogen beta chain / P02675* / Q8K0E8* / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain*  / reaction / complex
 ENSGALG00000031741 PTK2 / Q00944 / Focal adhesion kinase 1 / P34152* / Q05397* / protein tyrosine kinase 2* / PTK2 protein tyrosine kinase 2*  / reaction / complex
 ENSGALG00000039450 SOS1 / SOS Ras/Rac guanine nucleotide exchange factor 1 / Q07889* / Q62245* / Son of sevenless homolog 1 *  / complex / reaction
 ENSGALG00000015216 SYK / F1N9Y5 / Tyrosine-protein kinase SYK / P48025* / P43405* / spleen tyrosine kinase* / spleen associated tyrosine kinase*  / complex / reaction
 ENSGALG00000002656 CRK / Q04929 / Adapter molecule crk / P46108* / Q64010* / CRK proto-oncogene, adaptor protein*  / reaction / complex






 

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