ENSGALG00000008010


Gallus gallus

Features
Gene ID: ENSGALG00000008010
  
Biological name :PTPN1
  
Synonyms : PTPN1 / tyrosine-protein phosphatase non-receptor type 1
  
Possible biological names infered from orthology : P18031 / P35821 / protein tyrosine phosphatase, non-receptor type 1
  
Species: Gallus gallus
  
Chr. number: 20
Strand: -1
Band:
Gene start: 13756142
Gene end: 13795020
  
Corresponding Affymetrix probe sets: Gga.4404.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000012986
NCBI entrez gene - 395688     See in Manteia.
RefSeq - XM_015296333
RefSeq - NM_204875
RefSeq - XM_015296331
RefSeq - XM_015296332
RefSeq - XM_015296330
RefSeq Peptide - NP_990206
swissprot - A0A1I7Q402
Ensembl - ENSGALG00000008010
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptpn1ENSDARG00000007923Danio rerio
 PTPN1ENSG00000196396Homo sapiens
 Ptpn1ENSMUSG00000027540Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PTPN2 / protein tyrosine phosphatase, non-receptor type 2 / P17706* / Q06180* / Tyrosine-protein phosphatase non-receptor type 2 *ENSGALG0000001386748
PTPN9 / tyrosine-protein phosphatase non-receptor type 9 / O35239* / P43378* / protein tyrosine phosphatase, non-receptor type 9*ENSGALG0000000166423
PTPRB / protein tyrosine phosphatase, receptor type B / B2RU80* / P23467*ENSGALG0000001004923
PTPRJ / receptor-type tyrosine-protein phosphatase eta precursor / Q12913* / protein tyrosine phosphatase, receptor type J*ENSGALG0000000638222
PTPN22 / protein tyrosine phosphatase, non-receptor type 22 / P29352* / Q9Y2R2* / Tyrosine-protein phosphatase non-receptor type 22 *ENSGALG0000002165620
PTPRO / receptor-type tyrosine-protein phosphatase O / E9Q612* / Q16827* / protein tyrosine phosphatase, receptor type O*ENSGALG0000001308520
PTPRQ / protein tyrosine phosphatase, receptor type Q / P0C5E4* / Phosphatidylinositol phosphatase PTPRQ *ENSGALG0000001093519
ENSGALG0000002135514
P35831* / PTPN12* / Q05209* / protein tyrosine phosphatase, non-receptor type 12*ENSGALG000000425698
ENSGALG000000005844


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR012265  Protein-tyrosine phosphatase, non-receptor type-1/2
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR029021  Protein-tyrosine phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0007257 activation of JUN kinase activity IEA
 biological_processGO:0008286 insulin receptor signaling pathway IEA
 biological_processGO:0009966 regulation of signal transduction IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0030100 regulation of endocytosis IEA
 biological_processGO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway IEA
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response IEA
 biological_processGO:0031532 actin cytoskeleton reorganization IEA
 biological_processGO:0033157 regulation of intracellular protein transport IEA
 biological_processGO:0034976 response to endoplasmic reticulum stress IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0035791 platelet-derived growth factor receptor-beta signaling pathway IEA
 biological_processGO:0036498 IRE1-mediated unfolded protein response IEA
 biological_processGO:0043407 negative regulation of MAP kinase activity IEA
 biological_processGO:0061098 positive regulation of protein tyrosine kinase activity IEA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:1902202 regulation of hepatocyte growth factor receptor signaling pathway IEA
 biological_processGO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IEA
 biological_processGO:1903898 negative regulation of PERK-mediated unfolded protein response IEA
 biological_processGO:1990264 peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity IEA
 biological_processGO:2000646 positive regulation of receptor catabolic process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0097443 sorting endosome IEA
 cellular_componentGO:0098554 cytoplasmic side of endoplasmic reticulum membrane IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0030971 receptor tyrosine kinase binding IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0046875 ephrin receptor binding IEA


Pathways (from Reactome)
Pathway description
Integrin alphaIIb beta3 signaling
Negative regulation of MET activity
Regulation of IFNA signaling
Growth hormone receptor signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000003855 SRC / P00523 / Proto-oncogene tyrosine-protein kinase Src / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction
 ENSGALG00000015062 IFNK* / IFNA6* / IFNA7* / IFNA8* / Ifna9* / Ifnab* / IFNW1* / IFNA2* / IFNA4* / IFNA1* / IFNA5* / Q9P0W0* / IFNA10* / Ifna11* / Ifna12* / IFNA13* / IFNA14* / Ifna15* / IFNA16* / IFNA17* / I...  / reaction
 ENSGALG00000009927 RAP1B / Q5ZHX1 / Ras-related protein Rap-1b / Q99JI6* / P61224* / RAS related protein 1b* / RAP1B, member of RAS oncogene family*  / reaction
 ENSGALG00000000379 ITGB3 / P05106* / O54890* / AC068234.1* / Integrin beta-3 * / integrin subunit beta 3*  / reaction
 ENSGALG00000001476 RAP1A / RAP1A, member of RAS oncogene family / P62834* / P62835* / RAS-related protein 1a*  / reaction
 ENSGALG00000009262 FGB / fibrinogen beta chain / P02675* / Q8K0E8* / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain*  / reaction
 ENSGALG00000000249 GH / P08998 / Somatotropin / GH2* / GH1* / CSH1* / CSH2* / CSHL1* / Q14406* / P0DML3* / P0DML2* / P01241* / P01242* / P06880* / growth hormone 1* / growth hormone 2* / chorionic somatomamm...  / complex / reaction
 ENSGALG00000036883 MET / hepatocyte growth factor receptor precursor / P08581* / MET proto-oncogene, receptor tyrosine kinase*  / reaction
 ENSGALG00000003578 FN1 / fibronectin 1 / P02751* / P11276* / Fibronectin Anastellin*  / reaction
 ENSGALG00000002548 TLN1 / talin-1 / P26039* / Q9Y490*  / reaction
 ENSGALG00000009268 FGG / fibrinogen gamma chain / P02679* / Q8VCM7*  / reaction
 ENSGALG00000011031 JAK1 / tyrosine-protein kinase JAK1 / P23458* / Janus kinase 1*  / reaction
 ENSGALG00000015027 JAK2 / Janus kinase 2 / O60674*  / complex / reaction
 ENSGALG00000014855 GHR / growth hormone receptor precursor / P16882* / P10912* / growth hormone receptor* / Growth hormone receptor Growth hormone-binding protein*  / complex / reaction
 ENSGALG00000033974 HGF / hepatocyte growth factor / P14210* / Q08048* / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain*  / reaction
 ENSGALG00000030661 STAT2 / signal transducer and activator of transcription 2 / P52630*  / reaction
 ENSGALG00000007579 APBB1IP / amyloid beta precursor protein binding family B member 1 interacting protein / Q7Z5R6* / Q8R5A3* / amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein*  / reaction






 

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