ENSDARG00000007923


Danio rerio

Features
Gene ID: ENSDARG00000007923
  
Biological name :ptpn1
  
Synonyms : protein tyrosine phosphatase, non-receptor type 1 / ptpn1
  
Possible biological names infered from orthology : P18031 / P35821
  
Species: Danio rerio
  
Chr. number: 8
Strand: -1
Band:
Gene start: 28398780
Gene end: 28408410
  
Corresponding Affymetrix probe sets: Dr.8290.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000062692
NCBI entrez gene - 30081     See in Manteia.
RefSeq - NM_001313685
RefSeq Peptide - NP_001300614
swissprot - F1QDL0
ZFIN ID - ZDB-GENE-980605-23
Ensembl - ENSDARG00000007923
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PTPN1ENSGALG00000008010Gallus gallus
 PTPN1ENSG00000196396Homo sapiens
 Ptpn1ENSMUSG00000027540Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ptpn2b / protein tyrosine phosphatase, non-receptor type 2, b / PTPN2* / P17706* / Q06180* / protein tyrosine phosphatase, non-receptor type 2* / Tyrosine-protein phosphatase non-receptor type 2 *ENSDARG0000003598650
ptpn2a / protein tyrosine phosphatase, non-receptor type 2, a / PTPN2* / P17706* / Q06180* / protein tyrosine phosphatase, non-receptor type 2* / Tyrosine-protein phosphatase non-receptor type 2 *ENSDARG0000001648147
ptpn9b / protein tyrosine phosphatase, non-receptor type 9, bENSDARG0000007390226
ptpn9a / protein tyrosine phosphatase, non-receptor type 9, a / PTPN9* / O35239* / P43378* / protein tyrosine phosphatase, non-receptor type 9*ENSDARG0000007749522
ptpn22 / protein tyrosine phosphatase, non-receptor type 22 / P29352* / Q9Y2R2* / Tyrosine-protein phosphatase non-receptor type 22 *ENSDARG0000010419722
ptprh / protein tyrosine phosphatase, receptor type, hENSDARG0000007956021
ptprjb.2 / protein tyrosine phosphatase, receptor type, Jb, tandem duplicate 2 / PTPRJ* / Q12913* / protein tyrosine phosphatase, receptor type J*ENSDARG0000008651121
ptpn18 / protein tyrosine phosphatase, non-receptor type 18 / Q61152* / Q99952*ENSDARG0000000630821
ptprh / protein tyrosine phosphatase, receptor type, hENSDARG0000007829721
ptprjb.1 / protein tyrosine phosphatase, receptor type, Jb, tandem duplicate 1 / PTPRJ* / Q12913* / protein tyrosine phosphatase, receptor type J*ENSDARG0000009153920
ptprq / protein tyrosine phosphatase, receptor type, Q / P0C5E4* / Phosphatidylinositol phosphatase PTPRQ *ENSDARG0000000884920
ptprja / protein tyrosine phosphatase, receptor type, J a / PTPRJ* / Q12913* / protein tyrosine phosphatase, receptor type J*ENSDARG0000003304220
ptprb / protein tyrosine phosphatase, receptor type, b / P23467*ENSDARG0000007662420
ptpro / protein tyrosine phosphatase, receptor type, O / E9Q612* / Q16827* / Receptor-type tyrosine-protein phosphatase O *ENSDARG0000011047019
ptpro / protein tyrosine phosphatase, receptor type, OENSDARG000001004229


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR012265  Protein-tyrosine phosphatase, non-receptor type-1/2
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR029021  Protein-tyrosine phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA


Pathways (from Reactome)
Pathway description
Integrin alphaIIb beta3 signaling
Negative regulation of MET activity
PTK6 Down-Regulation
Growth hormone receptor signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000018882 jak2b / Janus kinase 2b / JAK2* / O60674* / Janus kinase 2*  / complex / reaction
 ENSDARG00000007671 ghrb / growth hormone receptor b / GHR* / P10912* / P16882* / growth hormone receptor* / Growth hormone receptor Growth hormone-binding protein*  / complex / reaction
 ENSDARG00000008867 rap1b / Q6TEN1 / RAP1B, member of RAS oncogene family / Q99JI6* / P61224* / RAS related protein 1b*  / reaction
 ENSDARG00000012553 rap1aa / RAP1A, member of RAS oncogene family a / RAP1B* / Q99JI6* / P61224* / RAS related protein 1b* / RAP1B, member of RAS oncogene family*  / reaction
 ENSDARG00000100729 tln1 / talin 1 / P26039* / Q9Y490*  / reaction
 ENSDARG00000077231 vwf / von Willebrand factor / P04275*  / reaction
 ENSDARG00000104808 jak2a / Janus kinase 2a / JAK2* / O60674* / Janus kinase 2*  / complex / reaction
 ENSDARG00000037281 fgg / fibrinogen gamma chain / P02679* / Q8VCM7*  / reaction
 ENSDARG00000038185 gh1 / growth hormone 1 / Gh* / GH2* / CSH2* / CSH1* / CSHL1* / P01242* / Q14406* / P0DML3* / P0DML2* / P01241* / P06880* / Somatotropin * / growth hormone 2* / chorionic somatomammotropin h...  / complex / reaction
 ENSDARG00000008107 src / Q1JPZ3 / v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyr...  / reaction
 ENSDARG00000006526 fn1b / fibronectin 1b / FN1* / P02751* / P11276* / fibronectin 1* / Fibronectin Anastellin*  / reaction
 ENSDARG00000045544 hgfa / hepatocyte growth factor a / HGF* / P14210* / Q08048* / hepatocyte growth factor* / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain*  / reaction
 ENSDARG00000020741 fga / fibrinogen alpha chain / E9PV24* / P02671* / Fibrinogen alpha chain Fibrinopeptide A Fibrinogen alpha chain*  / reaction
 ENSDARG00000008969 fgb / fibrinogen beta chain / P02675* / Q8K0E8* / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain*  / reaction
 ENSDARG00000087346 rap1ab / RAP1A, member of RAS oncogene family b / RAP1B* / Q99JI6* / P61224* / RAS related protein 1b* / RAP1B, member of RAS oncogene family*  / reaction
 ENSDARG00000019815 fn1a / fibronectin 1a / FN1* / P02751* / P11276* / fibronectin 1* / Fibronectin Anastellin*  / reaction
 ENSDARG00000070903 met / MET proto-oncogene, receptor tyrosine kinase / P08581*  / reaction
 ENSDARG00000059956 ptk6b / PTK6 protein tyrosine kinase 6b / PTK6* / Q64434* / Q13882* / protein tyrosine kinase 6* / PTK6 protein tyrosine kinase 6*  / reaction / complex
 ENSDARG00000017947 ptk6a / PTK6 protein tyrosine kinase 6a / PTK6* / Q64434* / Q13882* / protein tyrosine kinase 6* / PTK6 protein tyrosine kinase 6*  / reaction / complex






 

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