ENSDARG00000012553


Danio rerio

Features
Gene ID: ENSDARG00000012553
  
Biological name :rap1aa
  
Synonyms : rap1aa / RAP1A, member of RAS oncogene family a
  
Possible biological names infered from orthology : P61224 / Q99JI6 / RAP1B / RAP1B, member of RAS oncogene family / RAS related protein 1b
  
Species: Danio rerio
  
Chr. number: 8
Strand: -1
Band:
Gene start: 28267546
Gene end: 28274552
  
Corresponding Affymetrix probe sets: Dr.5310.1.S1_at (Zebrafish Array)   NM_001002152_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000050670
Ensembl peptide - ENSDARP00000116523
NCBI entrez gene - 415242     See in Manteia.
RefSeq - XM_005167023
RefSeq - NM_001002152
RefSeq Peptide - NP_001002152
swissprot - Q6IQP4
ZFIN ID - ZDB-GENE-040625-167
Ensembl - ENSDARG00000012553
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RAP1BENSGALG00000009927Gallus gallus
 RAP1BENSG00000127314Homo sapiens
 Rap1bENSMUSG00000052681Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
rap1ab / RAP1A, member of RAS oncogene family b / RAP1B* / Q99JI6* / P61224* / RAS related protein 1b* / RAP1B, member of RAS oncogene family*ENSDARG0000008734697
rap1b / Q6TEN1 / RAP1B, member of RAS oncogene family / Q99JI6* / P61224* / RAS related protein 1b*ENSDARG0000000886792
rap2c / RAP2C, member of RAS oncogene family / Q8BU31* / Q9Y3L5* / Ras-related protein Rap-2c *ENSDARG0000001564961
rap2aa / RAP2A, member of RAS oncogene family aENSDARG0000007755361
rap2b / RAP2B, member of RAS oncogene family / P61225* / P61226*ENSDARG0000010303261
rap2ab / RAP2A, member of RAS oncogene family bENSDARG0000004024660
rit1 / Ras-like without CAAX 1 / P70426* / Q92963* / GTP-binding protein Rit1 *ENSDARG0000006915047
diras1a / DIRAS family, GTP-binding RAS-like 1a / Q91Z61* / O95057* / DIRAS1* / DIRAS family GTPase 1* / GTP-binding protein Di-Ras1 *ENSDARG0000002806641
diras1b / DIRAS family, GTP-binding RAS-like 1b / Q91Z61* / O95057* / DIRAS1* / DIRAS family GTPase 1* / GTP-binding protein Di-Ras1 *ENSDARG0000000937241
rasd4 / rasd family member 4ENSDARG0000009923840
rasd1 / RAS, dexamethasone-induced 1 / Q9Y272* / O35626* / ras related dexamethasone induced 1* / Dexamethasone-induced Ras-related protein 1 *ENSDARG0000001927439
rasd3 / RASD family member 3ENSDARG0000005846434
si:dkey-27j5.5ENSDARG0000002638332
zgc:114118ENSDARG0000005222232
rasl10a / RAS-like, family 10, member AENSDARG0000006231429
RASL10B / RAS like family 10 member B / Q96S79*ENSDARG0000010943614


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR020849  Small GTPase superfamily, Ras-type
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0003428 chondrocyte intercalation involved in growth plate cartilage morphogenesis IGI
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007507 heart development IGI
 biological_processGO:0060026 convergent extension IGI
 biological_processGO:0060536 cartilage morphogenesis IGI
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0004708 MAP kinase kinase activity IGI
 molecular_functionGO:0005525 GTP binding IEA


Pathways (from Reactome)
Pathway description
Integrin alphaIIb beta3 signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
Rap1 signalling
MAP2K and MAPK activation
Neutrophil degranulation
MET activates RAP1 and RAC1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000155 somite somite increased width , abnormal
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 ZFA:0001094 whole organism whole organism decreased length , abnormal
whole organism increased curvature , abnormal
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 ZFA:0001114 head head decreased size , abnormal
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 ZFA:0001205 Meckel s cartilage Meckels cartilage decreased distance ceratohyal cartilage , abnormal
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 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage increased width , abnormal
ceratohyal cartilage kinked , abnormal
ceratohyal cartilage shortened , abnormal
ceratohyal cartilage chondrocyte disorganized , abnormal
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 ZFA:0009084 chondrocyte chondrocyte filamentous actin position , abnormal
chondrocyte myosin II filament position , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000044968 vcla / vinculin a / VCL* / Q64727* / P18206* / vinculin*  / complex
 ENSDARG00000020741 fga / fibrinogen alpha chain / E9PV24* / P02671* / Fibrinogen alpha chain Fibrinopeptide A Fibrinogen alpha chain*  / reaction / complex
 ENSDARG00000075437 shc1 / SHC (Src homology 2 domain containing) transforming protein 1 / P98083* / P29353* / SHC adaptor protein 1* / SHC-transforming protein 1 *  / reaction / complex
 ENSDARG00000008969 fgb / fibrinogen beta chain / P02675* / Q8K0E8* / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain*  / complex / reaction
 ENSDARG00000019815 fn1a / fibronectin 1a / FN1* / P02751* / P11276* / fibronectin 1* / Fibronectin Anastellin*  / reaction / complex
 ENSDARG00000008186 syk / spleen tyrosine kinase / P43405* / P48025* / spleen associated tyrosine kinase*  / complex / reaction
 ENSDARG00000037281 fgg / fibrinogen gamma chain / P02679* / Q8VCM7*  / reaction / complex
 ENSDARG00000055635 crk / v-crk avian sarcoma virus CT10 oncogene homolog / P46108* / Q64010* / Adapter molecule crk * / CRK proto-oncogene, adaptor protein*  / complex / reaction
 ENSDARG00000067996 csk / C-terminal Src kinase / P41240* / P41241* / Tyrosine-protein kinase CSK *  / reaction / complex
 ENSDARG00000008107 src / Q1JPZ3 / v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyr...  / reaction / complex
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / reaction / complex
 ENSDARG00000006526 fn1b / fibronectin 1b / FN1* / P02751* / P11276* / fibronectin 1* / Fibronectin Anastellin*  / reaction / complex
 ENSDARG00000056525 bcar1 / breast cancer anti-estrogen resistance 1 / Q61140* / P56945* / BCAR1, Cas family scaffolding protein* / Breast cancer anti-estrogen resistance protein 1 *  / complex / reaction
 ENSDARG00000100729 tln1 / talin 1 / P26039* / Q9Y490*  / complex / reaction
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000077231 vwf / von Willebrand factor / P04275*  / reaction / complex
 ENSDARG00000062328 rasgrp2 / RAS guanyl releasing protein 2 (calcium and DAG-regulated) / Q7LDG7* / Q9QUG9* / RAS guanyl releasing protein 2*  / reaction
 ENSDARG00000007923 ptpn1 / protein tyrosine phosphatase, non-receptor type 1 / P18031*  / reaction
 ENSDARG00000053272 si:dkey-166d12.2 / P47736* / RAP1GAP* / RAP1 GTPase activating protein*  / reaction
 ENSDARG00000061551 rap1gap2a / RAP1 GTPase activating protein 2a / Q5SVL6* / Q684P5* / RAP1GAP2* / RAP1 GTPase activating protein 2*  / reaction
 ENSDARG00000079291 rapgef3 / Rap guanine nucleotide exchange factor (GEF) 3 / Q8VCC8* / O95398* / Rap guanine nucleotide exchange factor 3* / Mus musculus Rap guanine nucleotide exchange factor (GEF) 3 (Rapge...  / reaction
 ENSDARG00000076697 zmp:0000001168 / SIPA1* / Q96FS4* / signal-induced proliferation-associated 1*  / reaction






 

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