ENSDARG00000079291


Danio rerio

Features
Gene ID: ENSDARG00000079291
  
Biological name :rapgef3
  
Synonyms : rapgef3 / Rap guanine nucleotide exchange factor (GEF) 3
  
Possible biological names infered from orthology : Mus musculus Rap guanine nucleotide exchange factor (GEF) 3 (Rapgef3), transcript variant 4, mRNA. / O95398 / Q8VCC8 / Rap guanine nucleotide exchange factor 3
  
Species: Danio rerio
  
Chr. number: 23
Strand: 1
Band:
Gene start: 33381154
Gene end: 33444055
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000098662
Ensembl peptide - ENSDARP00000122193
NCBI entrez gene - 101886094     See in Manteia.
swissprot - E7FDC9
swissprot - F1QWC5
ZFIN ID - ZDB-GENE-090312-38
Ensembl - ENSDARG00000079291
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RAPGEF3ENSGALG00000043775Gallus gallus
 O95398ENSG00000079337Homo sapiens
 Q8VCC8ENSMUSG00000022469Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
rapgef4 / Rap guanine nucleotide exchange factor (GEF) 4 / Q8WZA2* / Q9EQZ6* / Rap guanine nucleotide exchange factor 4*ENSDARG0000007987250
zgc:171558 / Q8WZA2* / Q9EQZ6* / RAPGEF4* / Rap guanine nucleotide exchange factor 4* / Rap guanine nucleotide exchange factor (GEF) 4*ENSDARG0000007592449
si:dkey-253i9.4ENSDARG0000006145924
rapgef2 / Rap guanine nucleotide exchange factor (GEF) 2 / Q8CHG7* / Q9Y4G8* / Rap guanine nucleotide exchange factor 2*ENSDARG0000000548223
rapgef5a / Rap guanine nucleotide exchange factor (GEF) 5a / Q92565* / RAPGEF5* / Rap guanine nucleotide exchange factor 5*ENSDARG0000007527122
rapgef6 / Rap guanine nucleotide exchange factor (GEF) 6 / Q8TEU7* / AC008695.1* / Rap guanine nucleotide exchange factor 6*ENSDARG0000001094521
rapgefl1 / Rap guanine nucleotide exchange factor (GEF)-like 1 / Q68EF8* / Q9UHV5* / Rap guanine nucleotide exchange factor like 1*ENSDARG0000007991220
Q6DHR3 / rasgef1ba / RasGEF domain family, member 1Ba / Q8JZL7* / Q0VAM2* / RASGEF1B* / RasGEF domain family member 1B* / Ras-GEF domain-containing family member 1B *ENSDARG0000003361411
RASGRP2 / RAS guanyl releasing protein 2 / Q7LDG7*ENSDARG0000009909210
rasgrp3 / RAS guanyl releasing protein 3 (calcium and DAG-regulated) / Q8IV61* / RAS guanyl releasing protein 3*ENSDARG0000007786410
Q6DBW1 / rasgef1bb / RasGEF domain family, member 1Bb / Q8JZL7* / Q0VAM2* / RASGEF1B* / RasGEF domain family member 1B* / Ras-GEF domain-containing family member 1B *ENSDARG0000004425110
rasgrp4 / RAS guanyl releasing protein 4 / Q8BTM9* / Q8TDF6*ENSDARG0000006179610
rasgrp2 / RAS guanyl releasing protein 2 (calcium and DAG-regulated) / Q7LDG7* / Q9QUG9* / RAS guanyl releasing protein 2*ENSDARG000000623289


Protein motifs (from Interpro)
Interpro ID Name
 IPR000591  DEP domain
 IPR000595  Cyclic nucleotide-binding domain
 IPR000651  Ras-like guanine nucleotide exchange factor, N-terminal
 IPR001895  Ras guanine-nucleotide exchange factors catalytic domain
 IPR011991  ArsR-like helix-turn-helix domain
 IPR014710  RmlC-like jelly roll fold
 IPR018490  Cyclic nucleotide-binding-like
 IPR019804  Ras guanine-nucleotide exchange factor, conserved site
 IPR023578  Ras guanine nucleotide exchange factor domain superfamily
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA


Pathways (from Reactome)
Pathway description
Integrin alphaIIb beta3 signaling
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Rap1 signalling
Regulation of insulin secretion


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000087346 rap1ab / RAP1A, member of RAS oncogene family b / RAP1B* / Q99JI6* / P61224* / RAS related protein 1b* / RAP1B, member of RAS oncogene family*  / reaction
 ENSDARG00000012553 rap1aa / RAP1A, member of RAS oncogene family a / RAP1B* / Q99JI6* / P61224* / RAS related protein 1b* / RAP1B, member of RAS oncogene family*  / reaction
 ENSDARG00000008867 rap1b / Q6TEN1 / RAP1B, member of RAS oncogene family / Q99JI6* / P61224* / RAS related protein 1b*  / reaction






 

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