ENSDARG00000075924


Danio rerio

Features
Gene ID: ENSDARG00000075924
  
Biological name :zgc:171558
  
Synonyms : zgc:171558
  
Possible biological names infered from orthology : Q8WZA2 / Q9EQZ6 / RAPGEF4 / Rap guanine nucleotide exchange factor 4 / Rap guanine nucleotide exchange factor (GEF) 4
  
Species: Danio rerio
  
Chr. number: 6
Strand: 1
Band:
Gene start: 6850821
Gene end: 6922290
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000098635
Ensembl peptide - ENSDARP00000135639
NCBI entrez gene - 100141331     See in Manteia.
RefSeq - NM_001114896
RefSeq Peptide - NP_001108368
swissprot - F1QCZ6
swissprot - A0A0R4IM06
ZFIN ID - ZDB-GENE-080219-4
Ensembl - ENSDARG00000075924
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RAPGEF4ENSGALG00000043694Gallus gallus
 Q8WZA2ENSG00000091428Homo sapiens
 Q9EQZ6ENSMUSG00000049044Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
rapgef4 / Rap guanine nucleotide exchange factor (GEF) 4 / Q8WZA2* / Q9EQZ6* / Rap guanine nucleotide exchange factor 4*ENSDARG0000007987277
rapgef3 / Rap guanine nucleotide exchange factor (GEF) 3 / Q8VCC8* / O95398* / Rap guanine nucleotide exchange factor 3* / Mus musculus Rap guanine nucleotide exchange factor (GEF) 3 (Rapge...ENSDARG0000007929142
rapgef2 / Rap guanine nucleotide exchange factor (GEF) 2 / Q8CHG7* / Q9Y4G8* / Rap guanine nucleotide exchange factor 2*ENSDARG0000000548225
si:dkey-253i9.4ENSDARG0000006145925
rapgef5a / Rap guanine nucleotide exchange factor (GEF) 5a / Q92565* / RAPGEF5* / Rap guanine nucleotide exchange factor 5*ENSDARG0000007527123
rapgefl1 / Rap guanine nucleotide exchange factor (GEF)-like 1 / Q68EF8* / Q9UHV5* / Rap guanine nucleotide exchange factor like 1*ENSDARG0000007991221
rapgef6 / Rap guanine nucleotide exchange factor (GEF) 6 / Q8TEU7* / AC008695.1* / Rap guanine nucleotide exchange factor 6*ENSDARG0000001094520
Q6DHR3 / rasgef1ba / RasGEF domain family, member 1Ba / Q8JZL7* / Q0VAM2* / RASGEF1B* / RasGEF domain family member 1B* / Ras-GEF domain-containing family member 1B *ENSDARG0000003361411
Q6DBW1 / rasgef1bb / RasGEF domain family, member 1Bb / Q8JZL7* / Q0VAM2* / RASGEF1B* / RasGEF domain family member 1B* / Ras-GEF domain-containing family member 1B *ENSDARG000000442519
rasgrp4 / RAS guanyl releasing protein 4 / Q8BTM9* / Q8TDF6*ENSDARG000000617968
rasgrp3 / RAS guanyl releasing protein 3 (calcium and DAG-regulated) / Q8IV61* / RAS guanyl releasing protein 3*ENSDARG000000778648
RASGRP2 / RAS guanyl releasing protein 2 / Q7LDG7*ENSDARG000000990927
rasgrp2 / RAS guanyl releasing protein 2 (calcium and DAG-regulated) / Q7LDG7* / Q9QUG9* / RAS guanyl releasing protein 2*ENSDARG000000623287


Protein motifs (from Interpro)
Interpro ID Name
 IPR000159  Ras-associating (RA) domain
 IPR000591  DEP domain
 IPR000595  Cyclic nucleotide-binding domain
 IPR000651  Ras-like guanine nucleotide exchange factor, N-terminal
 IPR001895  Ras guanine-nucleotide exchange factors catalytic domain
 IPR011991  ArsR-like helix-turn-helix domain
 IPR014710  RmlC-like jelly roll fold
 IPR018490  Cyclic nucleotide-binding-like
 IPR019804  Ras guanine-nucleotide exchange factor, conserved site
 IPR023578  Ras guanine nucleotide exchange factor domain superfamily
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA


Pathways (from Reactome)
Pathway description
Integrin alphaIIb beta3 signaling
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Rap1 signalling
Regulation of insulin secretion


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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