ENSMUSG00000049044


Mus musculus

Features
Gene ID: ENSMUSG00000049044
  
Biological name :Rapgef4
  
Synonyms : Q9EQZ6 / Rapgef4 / Rap guanine nucleotide exchange factor (GEF) 4
  
Possible biological names infered from orthology : Q8WZA2 / Rap guanine nucleotide exchange factor 4
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: C3
Gene start: 71981240
Gene end: 72257474
  
Corresponding Affymetrix probe sets: 10472860 (MoGene1.0st)   1421622_a_at (Mouse Genome 430 2.0 Array)   1425518_at (Mouse Genome 430 2.0 Array)   1440274_at (Mouse Genome 430 2.0 Array)   1444034_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099759
Ensembl peptide - ENSMUSP00000028525
Ensembl peptide - ENSMUSP00000088336
NCBI entrez gene - 56508     See in Manteia.
MGI - MGI:1917723
RefSeq - XM_017319139
RefSeq - NM_001204165
RefSeq - NM_001204166
RefSeq - NM_019688
RefSeq - XM_006499938
RefSeq - XM_011239711
RefSeq - XM_017319138
RefSeq Peptide - NP_062662
RefSeq Peptide - NP_001191094
RefSeq Peptide - NP_001191095
swissprot - A2ASW8
swissprot - Q9EQZ6
swissprot - A2ASW4
Ensembl - ENSMUSG00000049044
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rapgef4ENSDARG00000079872Danio rerio
 zgc:171558ENSDARG00000075924Danio rerio
 RAPGEF4ENSGALG00000043694Gallus gallus
 Q8WZA2ENSG00000091428Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8VCC8 / Rapgef3 / Mus musculus Rap guanine nucleotide exchange factor (GEF) 3 (Rapgef3), transcript variant 4, mRNA. / O95398* / Rap guanine nucleotide exchange factor 3*ENSMUSG0000002246943
Q8C0Q9 / Rapgef5 / Rap guanine nucleotide exchange factor 5 / Q92565*ENSMUSG0000004199233
Rapgef6 / Rap guanine nucleotide exchange factor (GEF) 6 / Q8TEU7* / AC008695.1* / Rap guanine nucleotide exchange factor 6*ENSMUSG0000003753324
Q68EF8 / Rapgefl1 / Rap guanine nucleotide exchange factor-like 1 / Q9UHV5*ENSMUSG0000003802023
Q8CHG7 / Rapgef2 / Rap guanine nucleotide exchange factor 2 / Q9Y4G8*ENSMUSG0000006223220
Rasgef1a / RasGEF domain family, member 1A / Q8N9B8*ENSMUSG0000003013410
Rasgrp3 / RAS, guanyl releasing protein 3 / Q8IV61*ENSMUSG000000710429
Q9D300 / Rasgef1c / Ras-GEF domain-containing family member 1C / Q8N431* / RasGEF domain family member 1C*ENSMUSG000000203749
Q8JZL7 / Rasgef1b / Ras-GEF domain-containing family member 1B / Q0VAM2* / RasGEF domain family member 1B*ENSMUSG000000898099
Q9Z1S3 / Rasgrp1 / RAS guanyl releasing protein 1 / O95267*ENSMUSG000000273479
Q8BTM9 / Rasgrp4 / RAS guanyl releasing protein 4 / Q8TDF6*ENSMUSG000000305899
Q9QUG9 / Rasgrp2 / RAS, guanyl releasing protein 2 / Q7LDG7*ENSMUSG000000329468


Protein motifs (from Interpro)
Interpro ID Name
 IPR000591  DEP domain
 IPR000595  Cyclic nucleotide-binding domain
 IPR000651  Ras-like guanine nucleotide exchange factor, N-terminal
 IPR001895  Ras guanine-nucleotide exchange factors catalytic domain
 IPR014710  RmlC-like jelly roll fold
 IPR018490  Cyclic nucleotide-binding-like
 IPR019804  Ras guanine-nucleotide exchange factor, conserved site
 IPR023578  Ras guanine nucleotide exchange factor domain superfamily
 IPR029071  Ubiquitin-like domain superfamily
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily
 IPR036964  Ras guanine-nucleotide exchange factor catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0017156 calcium ion regulated exocytosis IDA
 biological_processGO:0017157 regulation of exocytosis IDA
 biological_processGO:0019933 cAMP-mediated signaling IDA
 biological_processGO:0030073 insulin secretion IDA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017016 Ras GTPase binding IPI
 molecular_functionGO:0030552 cAMP binding IEA


Pathways (from Reactome)
Pathway description
Integrin alphaIIb beta3 signaling
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Rap1 signalling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003564 abnormal insulin secretion "aberrant release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Fbxw7tm1Kei/Fbxw7tm1Kei,Rbpjtm1Hon/Rbpjtm1Hon,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0004088 abnormal sarcoplasmic reticulum morphology "any structural abnormality in the endoplasmic reticulum of skeletal and cardiac muscle, i.e. the complex of vesicles, tubules, and cisternae that form a continuous structure around striated myofibrils, with a repetition of structure within each sarcomere " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Cryabtm1.1Ady/Cryabtm1.1Ady
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Rapgef3tm1.2Chen/Rapgef3tm1.2Chen,Rapgef4tm1.2Chen/Rapgef4tm1.2Chen
Genetic Background: involves: 129 * Black Swiss * C57BL/6 * SJL

 MP:0004231 abnormal calcium ion homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of calcium ions within the body or between a cell and its external environment" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tyrc-55H/Tyrc-55H
Genetic Background: involves: 101/H * C3H/HeH

 MP:0008950 ventricular tachycardia "paroxysmal rapid beating of the heart originating in an ectopic focus in the heart ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cryabtm1.1Ady/Cryabtm1.1Ady
Genetic Background: involves: 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000068798 Rap1a / P62835 / RAS-related protein 1a / P62834* / RAP1A, member of RAS oncogene family*  / reaction
 ENSMUSG00000052681 Rap1b / Q99JI6 / RAS related protein 1b / P61224* / RAP1B, member of RAS oncogene family*  / reaction






 

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