ENSMUSG00000032946


Mus musculus

Features
Gene ID: ENSMUSG00000032946
  
Biological name :Rasgrp2
  
Synonyms : Q9QUG9 / Rasgrp2 / RAS, guanyl releasing protein 2
  
Possible biological names infered from orthology : Q7LDG7
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: A
Gene start: 6399340
Gene end: 6415216
  
Corresponding Affymetrix probe sets: 10460968 (MoGene1.0st)   1417804_at (Mouse Genome 430 2.0 Array)   1438932_at (Mouse Genome 430 2.0 Array)   1438933_x_at (Mouse Genome 430 2.0 Array)   1442264_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000109103
Ensembl peptide - ENSMUSP00000129873
Ensembl peptide - ENSMUSP00000123036
Ensembl peptide - ENSMUSP00000121635
Ensembl peptide - ENSMUSP00000120949
Ensembl peptide - ENSMUSP00000120630
Ensembl peptide - ENSMUSP00000119740
Ensembl peptide - ENSMUSP00000117681
Ensembl peptide - ENSMUSP00000109104
Ensembl peptide - ENSMUSP00000041135
Ensembl peptide - ENSMUSP00000109095
Ensembl peptide - ENSMUSP00000109096
Ensembl peptide - ENSMUSP00000109097
Ensembl peptide - ENSMUSP00000109099
Ensembl peptide - ENSMUSP00000109100
NCBI entrez gene - 19395     See in Manteia.
MGI - MGI:1333849
RefSeq - XM_017318082
RefSeq - XM_006531686
RefSeq - XM_006531687
RefSeq - XM_006531688
RefSeq - XM_006531689
RefSeq - XM_006531690
RefSeq - XM_006531691
RefSeq - XM_006531692
RefSeq - XM_011248612
RefSeq - XM_011248613
RefSeq - XM_011248615
RefSeq - NM_011242
RefSeq - XM_006531685
RefSeq Peptide - NP_035372
swissprot - D3YZX2
swissprot - D3YZP4
swissprot - D3YZP2
swissprot - D3YZP1
swissprot - D3YXD6
swissprot - D3Z3N3
swissprot - D6RDD3
swissprot - D3Z2F9
swissprot - Q9QUG9
Ensembl - ENSMUSG00000032946
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rasgrp2ENSDARG00000062328Danio rerio
 RASGRP2ENSDARG00000099092Danio rerio
 Q7LDG7ENSG00000068831Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rasgrp3 / RAS, guanyl releasing protein 3 / Q8IV61*ENSMUSG0000007104251
Q9Z1S3 / Rasgrp1 / RAS guanyl releasing protein 1 / O95267*ENSMUSG0000002734743
Q8BTM9 / Rasgrp4 / RAS guanyl releasing protein 4 / Q8TDF6*ENSMUSG0000003058941
Q8CHG7 / Rapgef2 / Rap guanine nucleotide exchange factor 2 / Q9Y4G8*ENSMUSG0000006223217
Rapgef6 / Rap guanine nucleotide exchange factor (GEF) 6 / Q8TEU7* / AC008695.1* / Rap guanine nucleotide exchange factor 6*ENSMUSG0000003753316
Q8VCC8 / Rapgef3 / Mus musculus Rap guanine nucleotide exchange factor (GEF) 3 (Rapgef3), transcript variant 4, mRNA. / O95398* / Rap guanine nucleotide exchange factor 3*ENSMUSG0000002246915
Q8C0Q9 / Rapgef5 / Rap guanine nucleotide exchange factor 5 / Q92565*ENSMUSG0000004199213
Q9EQZ6 / Rapgef4 / Rap guanine nucleotide exchange factor (GEF) 4 / Q8WZA2* / Rap guanine nucleotide exchange factor 4*ENSMUSG0000004904413
Rasgef1a / RasGEF domain family, member 1A / Q8N9B8*ENSMUSG0000003013413
Q8JZL7 / Rasgef1b / Ras-GEF domain-containing family member 1B / Q0VAM2* / RasGEF domain family member 1B*ENSMUSG0000008980913
Q9D300 / Rasgef1c / Ras-GEF domain-containing family member 1C / Q8N431* / RasGEF domain family member 1C*ENSMUSG0000002037413
Q68EF8 / Rapgefl1 / Rap guanine nucleotide exchange factor-like 1 / Q9UHV5*ENSMUSG0000003802011


Protein motifs (from Interpro)
Interpro ID Name
 IPR000651  Ras-like guanine nucleotide exchange factor, N-terminal
 IPR001895  Ras guanine-nucleotide exchange factors catalytic domain
 IPR002048  EF-hand domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site
 IPR023578  Ras guanine nucleotide exchange factor domain superfamily
 IPR036964  Ras guanine-nucleotide exchange factor catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity ISO
 biological_processGO:0071277 cellular response to calcium ion ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity ISO
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Integrin alphaIIb beta3 signaling
Rap1 signalling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tcirg1tm1Utku/Tcirg1tm1Utku
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tcirg1tm1Utku/Tcirg1tm1Utku
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005606 increased bleeding time "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Tcirg1tm1Utku/Tcirg1tm1Utku
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008719 impaired neutrophil recruitment "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tcirg1tm1Utku/Tcirg1tm1Utku
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0009549 impaired platelet aggregation "decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
Show

Allelic Composition: Tcirg1tm1Utku/Tcirg1tm1Utku
Genetic Background: involves: 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000052681 Rap1b / Q99JI6 / RAS related protein 1b / P61224* / RAP1B, member of RAS oncogene family*  / reaction
 ENSMUSG00000068798 Rap1a / P62835 / RAS-related protein 1a / P62834* / RAP1A, member of RAS oncogene family*  / reaction






 

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