ENSMUSG00000022469


Mus musculus

Features
Gene ID: ENSMUSG00000022469
  
Biological name :Rapgef3
  
Synonyms : Mus musculus Rap guanine nucleotide exchange factor (GEF) 3 (Rapgef3), transcript variant 4, mRNA. / Q8VCC8 / Rapgef3
  
Possible biological names infered from orthology : O95398 / Rap guanine nucleotide exchange factor 3
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: F1
Gene start: 97744770
Gene end: 97767972
  
Corresponding Affymetrix probe sets: 10431974 (MoGene1.0st)   1424470_a_at (Mouse Genome 430 2.0 Array)   1424471_at (Mouse Genome 430 2.0 Array)   1437012_x_at (Mouse Genome 430 2.0 Array)   1437946_x_at (Mouse Genome 430 2.0 Array)   1438590_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000122285
Ensembl peptide - ENSMUSP00000122746
Ensembl peptide - ENSMUSP00000135317
Ensembl peptide - ENSMUSP00000135238
Ensembl peptide - ENSMUSP00000135194
Ensembl peptide - ENSMUSP00000116426
Ensembl peptide - ENSMUSP00000116673
Ensembl peptide - ENSMUSP00000117337
Ensembl peptide - ENSMUSP00000118148
Ensembl peptide - ENSMUSP00000120126
NCBI entrez gene - 223864     See in Manteia.
MGI - MGI:2441741
RefSeq - XM_011245600
RefSeq - XM_017316584
RefSeq - XM_017316583
RefSeq - XM_006520876
RefSeq - XM_017316582
RefSeq - XM_011245603
RefSeq - XM_011245602
RefSeq - XM_011245601
RefSeq - NM_001177810
RefSeq - NM_001177811
RefSeq - NM_001357630
RefSeq - NM_144850
RefSeq - XM_017316585
RefSeq Peptide - NP_001171282
RefSeq Peptide - NP_001171281
RefSeq Peptide - NP_001344559
RefSeq Peptide - NP_659099
swissprot - Q8VCC8
swissprot - E9Q2E5
swissprot - D3Z4E9
swissprot - H3BKA8
swissprot - H3BK39
swissprot - H3BK02
swissprot - F7BXV7
swissprot - D3Z514
swissprot - D6RGA9
Ensembl - ENSMUSG00000022469
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rapgef3ENSDARG00000079291Danio rerio
 RAPGEF3ENSGALG00000043775Gallus gallus
 O95398ENSG00000079337Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9EQZ6 / Rapgef4 / Rap guanine nucleotide exchange factor (GEF) 4 / Q8WZA2* / Rap guanine nucleotide exchange factor 4*ENSMUSG0000004904447
Q8C0Q9 / Rapgef5 / Rap guanine nucleotide exchange factor 5 / Q92565*ENSMUSG0000004199230
Q68EF8 / Rapgefl1 / Rap guanine nucleotide exchange factor-like 1 / Q9UHV5*ENSMUSG0000003802023
Rapgef6 / Rap guanine nucleotide exchange factor (GEF) 6 / Q8TEU7* / AC008695.1* / Rap guanine nucleotide exchange factor 6*ENSMUSG0000003753323
Q8CHG7 / Rapgef2 / Rap guanine nucleotide exchange factor 2 / Q9Y4G8*ENSMUSG0000006223222
Q8BTM9 / Rasgrp4 / RAS guanyl releasing protein 4 / Q8TDF6*ENSMUSG0000003058912
Rasgef1a / RasGEF domain family, member 1A / Q8N9B8*ENSMUSG0000003013411
Q8JZL7 / Rasgef1b / Ras-GEF domain-containing family member 1B / Q0VAM2* / RasGEF domain family member 1B*ENSMUSG0000008980910
Q9QUG9 / Rasgrp2 / RAS, guanyl releasing protein 2 / Q7LDG7*ENSMUSG0000003294610
Q9D300 / Rasgef1c / Ras-GEF domain-containing family member 1C / Q8N431* / RasGEF domain family member 1C*ENSMUSG0000002037410
Rasgrp3 / RAS, guanyl releasing protein 3 / Q8IV61*ENSMUSG0000007104210
Q9Z1S3 / Rasgrp1 / RAS guanyl releasing protein 1 / O95267*ENSMUSG0000002734710


Protein motifs (from Interpro)
Interpro ID Name
 IPR000591  DEP domain
 IPR000595  Cyclic nucleotide-binding domain
 IPR000651  Ras-like guanine nucleotide exchange factor, N-terminal
 IPR001895  Ras guanine-nucleotide exchange factors catalytic domain
 IPR014710  RmlC-like jelly roll fold
 IPR018490  Cyclic nucleotide-binding-like
 IPR019804  Ras guanine-nucleotide exchange factor, conserved site
 IPR023578  Ras guanine nucleotide exchange factor domain superfamily
 IPR029071  Ubiquitin-like domain superfamily
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily
 IPR036964  Ras guanine-nucleotide exchange factor catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0032486 Rap protein signal transduction ISS
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation ISO
 biological_processGO:0034242 negative regulation of syncytium formation by plasma membrane fusion ISO
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity ISS
 biological_processGO:0045766 positive regulation of angiogenesis ISS
 biological_processGO:0046827 positive regulation of protein export from nucleus ISO
 biological_processGO:0051496 positive regulation of stress fiber assembly ISO
 biological_processGO:0060143 positive regulation of syncytium formation by plasma membrane fusion ISO
 biological_processGO:0061028 establishment of endothelial barrier ISS
 biological_processGO:0071320 cellular response to cAMP ISS
 biological_processGO:1901985 positive regulation of protein acetylation ISO
 biological_processGO:2000249 regulation of actin cytoskeleton reorganization ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005902 microvillus ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030027 lamellipodium ISO
 cellular_componentGO:0030175 filopodium ISO
 cellular_componentGO:0030864 cortical actin cytoskeleton ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017034 Rap guanyl-nucleotide exchange factor activity ISS
 molecular_functionGO:0019904 protein domain specific binding ISO
 molecular_functionGO:0030552 cAMP binding IEA


Pathways (from Reactome)
Pathway description
Integrin alphaIIb beta3 signaling
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Rap1 signalling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kmt2bGena263/Kmt2bGena263
Genetic Background: involves: BALB/c * C3H/HeH

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Kmt2bGena263/Kmt2bGena263
Genetic Background: involves: BALB/c * C3H/HeH

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Arxtm5Kki/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: Kmt2bGena263/Kmt2bGena263
Genetic Background: involves: BALB/c * C3H/HeH

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Kmt2bGena263/Kmt2bGena263
Genetic Background: involves: BALB/c * C3H/HeH

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Arxtm5Kki/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kmt2bGena263/Kmt2bGena263
Genetic Background: involves: BALB/c * C3H/HeH

Allelic Composition: Rapgef3tm1.1Chen/Rapgef3tm1.1Chen
Genetic Background: B6.129(Cg)-Rapgef3tm1.1Chen

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Rapgef3tm1.1Chen/Rapgef3tm1.1Chen
Genetic Background: B6.129(Cg)-Rapgef3tm1.1Chen

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Kmt2bGena263/Kmt2bGena263
Genetic Background: involves: BALB/c * C3H/HeH

 MP:0003204 decreased neuron apoptosis "decrease in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Dkk1tm1Lmgd/Dkk1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003562 abnormal beta cell physiology "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Kmt2bGena263/Kmt2bGena263
Genetic Background: involves: BALB/c * C3H/HeH

 MP:0004031 insulitis "a histologic change in the islets of Langerhans characterized by edema and the infiltration of small numbers of white blood cells" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Kmt2bGena263/Kmt2bGena263
Genetic Background: involves: BALB/c * C3H/HeH

 MP:0004088 abnormal sarcoplasmic reticulum morphology "any structural abnormality in the endoplasmic reticulum of skeletal and cardiac muscle, i.e. the complex of vesicles, tubules, and cisternae that form a continuous structure around striated myofibrils, with a repetition of structure within each sarcomere " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cryabtm1.1Ady/Cryabtm1.1Ady
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kmt2bGena263/Kmt2bGena263
Genetic Background: involves: BALB/c * C3H/HeH

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rapgef3tm1.1Chen/Rapgef3tm1.1Chen
Genetic Background: B6.129(Cg)-Rapgef3tm1.1Chen

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Kmt2bGena263/Kmt2bGena263
Genetic Background: involves: BALB/c * C3H/HeH

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kmt2bGena263/Kmt2bGena263
Genetic Background: involves: BALB/c * C3H/HeH

 MP:0005491 islet cell hyperplasia "increased numbers cells within the structures that are scattered throughout the pancreas and comprise its endocrine portion" [J:48446, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Kmt2bGena263/Kmt2bGena263
Genetic Background: involves: BALB/c * C3H/HeH

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rapgef3tm1.1Chen/Rapgef3tm1.1Chen
Genetic Background: B6.129(Cg)-Rapgef3tm1.1Chen

 MP:0005566 decreased blood urea nitrogen level "low circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kmt2bGena263/Kmt2bGena263
Genetic Background: involves: BALB/c * C3H/HeH

 MP:0005658 susceptibility to diet-induced obesity "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Kmt2bGena263/Kmt2bGena263
Genetic Background: involves: BALB/c * C3H/HeH

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Rapgef3tm1.1Chen/Rapgef3tm1.1Chen
Genetic Background: B6.129(Cg)-Rapgef3tm1.1Chen

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rapgef3tm1.1Chen/Rapgef3tm1.1Chen
Genetic Background: B6.129(Cg)-Rapgef3tm1.1Chen

 MP:0009133 decreased white fat cell size "reduction in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rapgef3tm1.1Chen/Rapgef3tm1.1Chen
Genetic Background: B6.129(Cg)-Rapgef3tm1.1Chen

 MP:0009171 enlarged pancreatic islets "increase in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
Show

Allelic Composition: Kmt2bGena263/Kmt2bGena263
Genetic Background: involves: BALB/c * C3H/HeH

 MP:0009176 increased pancreatic alpha cell number "increase in the number of the cells of the pancreas that secrete glucagon" [MESH:A03.734.414.065]
Show

Allelic Composition: Kmt2bGena263/Kmt2bGena263
Genetic Background: involves: BALB/c * C3H/HeH

 MP:0009289 decreased epididymal fat pad weight 
Show

Allelic Composition: Rapgef3tm1.1Chen/Rapgef3tm1.1Chen
Genetic Background: B6.129(Cg)-Rapgef3tm1.1Chen

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rapgef3tm1.1Chen/Rapgef3tm1.1Chen
Genetic Background: B6.129(Cg)-Rapgef3tm1.1Chen

 MP:0010378 increased respiratory quotient "increase in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kmt2bGena263/Kmt2bGena263
Genetic Background: involves: BALB/c * C3H/HeH

 MP:0011167 abnormal adipose tissue development "anomaly in the process of the formation of the connective tissue composed of fat cells enmeshed in areolar tissue" [MESH:A10.165.114, MGI:csmith]
Show

Allelic Composition: Rapgef3tm1.1Chen/Rapgef3tm1.1Chen
Genetic Background: B6.129(Cg)-Rapgef3tm1.1Chen

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Rapgef3tm1.1Chen/Rapgef3tm1.1Chen
Genetic Background: B6.129(Cg)-Rapgef3tm1.1Chen

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000052681 Rap1b / Q99JI6 / RAS related protein 1b / P61224* / RAP1B, member of RAS oncogene family*  / reaction
 ENSMUSG00000068798 Rap1a / P62835 / RAS-related protein 1a / P62834* / RAP1A, member of RAS oncogene family*  / reaction






 

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