ENSG00000091428


Homo sapiens

Features
Gene ID: ENSG00000091428
  
Biological name :RAPGEF4
  
Synonyms : Q8WZA2 / RAPGEF4 / Rap guanine nucleotide exchange factor 4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q31.1
Gene start: 172735274
Gene end: 173052893
  
Corresponding Affymetrix probe sets: 205651_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000438011
Ensembl peptide - ENSP00000387104
Ensembl peptide - ENSP00000440135
Ensembl peptide - ENSP00000440250
Ensembl peptide - ENSP00000380271
Ensembl peptide - ENSP00000380274
Ensembl peptide - ENSP00000380276
NCBI entrez gene - 11069     See in Manteia.
OMIM - 606058
RefSeq - XM_017003197
RefSeq - NM_001100397
RefSeq - NM_001282899
RefSeq - NM_001282900
RefSeq - NM_001282901
RefSeq - NM_007023
RefSeq - XM_005246246
RefSeq - XM_006712205
RefSeq - XM_011510505
RefSeq - XM_017003196
RefSeq Peptide - NP_001269828
RefSeq Peptide - NP_001269829
RefSeq Peptide - NP_001269830
RefSeq Peptide - NP_008954
RefSeq Peptide - NP_001093867
swissprot - H7BYQ0
swissprot - Q8WZA2
swissprot - B7Z278
swissprot - E9PB94
Ensembl - ENSG00000091428
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rapgef4ENSDARG00000079872Danio rerio
 zgc:171558ENSDARG00000075924Danio rerio
 RAPGEF4ENSGALG00000043694Gallus gallus
 Q9EQZ6ENSMUSG00000049044Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O95398 / RAPGEF3 / Rap guanine nucleotide exchange factor 3ENSG0000007933743
Q92565 / RAPGEF5 / Rap guanine nucleotide exchange factor 5ENSG0000013623731
AC008695.1ENSG0000027321723
Q8TEU7 / RAPGEF6 / Rap guanine nucleotide exchange factor 6ENSG0000015898723
Q9Y4G8 / RAPGEF2 / Rap guanine nucleotide exchange factor 2ENSG0000010975621
Q9UHV5 / RAPGEFL1 / Rap guanine nucleotide exchange factor like 1ENSG0000010835220
Q8TDF6 / RASGRP4 / RAS guanyl releasing protein 4ENSG0000017177710
Q8N9B8 / RASGEF1A / RasGEF domain family member 1AENSG0000019891510
O95267 / RASGRP1 / RAS guanyl releasing protein 1ENSG000001725759
Q8IV61 / RASGRP3 / RAS guanyl releasing protein 3ENSG000001526899
Q8N431 / RASGEF1C / RasGEF domain family member 1CENSG000001460909
Q0VAM2 / RASGEF1B / RasGEF domain family member 1BENSG000001386709
Q7LDG7 / RASGRP2 / RAS guanyl releasing protein 2ENSG000000688318


Protein motifs (from Interpro)
Interpro ID Name
 IPR000591  DEP domain
 IPR000595  Cyclic nucleotide-binding domain
 IPR000651  Ras-like guanine nucleotide exchange factor, N-terminal
 IPR001895  Ras guanine-nucleotide exchange factors catalytic domain
 IPR014710  RmlC-like jelly roll fold
 IPR018490  Cyclic nucleotide-binding-like
 IPR019804  Ras guanine-nucleotide exchange factor, conserved site
 IPR023578  Ras guanine nucleotide exchange factor domain superfamily
 IPR029071  Ubiquitin-like domain superfamily
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily
 IPR036964  Ras guanine-nucleotide exchange factor catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0017156 calcium ion regulated exocytosis IEA
 biological_processGO:0017157 regulation of exocytosis IEA
 biological_processGO:0019933 cAMP-mediated signaling IEA
 biological_processGO:0030073 insulin secretion IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0050796 regulation of insulin secretion TAS
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017016 Ras GTPase binding ISS
 molecular_functionGO:0030552 cAMP binding ISS


Pathways (from Reactome)
Pathway description
Integrin alphaIIb beta3 signaling
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Rap1 signalling
Regulation of insulin secretion


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000127314 RAP1B / P61224 / RAP1B, member of RAS oncogene family  / reaction
 ENSG00000116473 RAP1A / P62834 / RAP1A, member of RAS oncogene family  / reaction






 

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