ENSG00000171777


Homo sapiens

Features
Gene ID: ENSG00000171777
  
Biological name :RASGRP4
  
Synonyms : Q8TDF6 / RASGRP4 / RAS guanyl releasing protein 4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: q13.2
Gene start: 38409051
Gene end: 38426305
  
Corresponding Affymetrix probe sets: 231328_s_at (Human Genome U133 Plus 2.0 Array)   240862_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000479888
Ensembl peptide - ENSP00000484345
Ensembl peptide - ENSP00000481053
Ensembl peptide - ENSP00000293062
Ensembl peptide - ENSP00000411878
Ensembl peptide - ENSP00000416463
Ensembl peptide - ENSP00000445966
Ensembl peptide - ENSP00000465742
Ensembl peptide - ENSP00000465772
Ensembl peptide - ENSP00000466928
Ensembl peptide - ENSP00000467604
Ensembl peptide - ENSP00000468483
Ensembl peptide - ENSP00000479078
Ensembl peptide - ENSP00000479844
NCBI entrez gene - 115727     See in Manteia.
OMIM - 607320
RefSeq - NM_001146202
RefSeq - NM_001146203
RefSeq - NM_001146204
RefSeq - NM_001146205
RefSeq - NM_001146206
RefSeq - NM_170604
RefSeq - NM_001146207
RefSeq Peptide - NP_001139679
RefSeq Peptide - NP_001139674
RefSeq Peptide - NP_001139675
RefSeq Peptide - NP_001139676
RefSeq Peptide - NP_001139677
RefSeq Peptide - NP_001139678
RefSeq Peptide - NP_733749
swissprot - Q8TDF6
swissprot - C0LTP6
Ensembl - ENSG00000171777
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rasgrp4ENSDARG00000061796Danio rerio
 Q8BTM9ENSMUSG00000030589Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O95267 / RASGRP1 / RAS guanyl releasing protein 1ENSG0000017257545
Q8IV61 / RASGRP3 / RAS guanyl releasing protein 3ENSG0000015268939
Q7LDG7 / RASGRP2 / RAS guanyl releasing protein 2ENSG0000006883137
Q9Y4G8 / RAPGEF2 / Rap guanine nucleotide exchange factor 2ENSG0000010975618
Q8TEU7 / RAPGEF6 / Rap guanine nucleotide exchange factor 6ENSG0000015898718
AC008695.1ENSG0000027321718
O95398 / RAPGEF3 / Rap guanine nucleotide exchange factor 3ENSG0000007933716
Q8WZA2 / RAPGEF4 / Rap guanine nucleotide exchange factor 4ENSG0000009142814
Q8N9B8 / RASGEF1A / RasGEF domain family member 1AENSG0000019891512
Q92565 / RAPGEF5 / Rap guanine nucleotide exchange factor 5ENSG0000013623712
Q8N431 / RASGEF1C / RasGEF domain family member 1CENSG0000014609012
Q9UHV5 / RAPGEFL1 / Rap guanine nucleotide exchange factor like 1ENSG0000010835211
Q0VAM2 / RASGEF1B / RasGEF domain family member 1BENSG0000013867011


Protein motifs (from Interpro)
Interpro ID Name
 IPR000651  Ras-like guanine nucleotide exchange factor, N-terminal
 IPR001895  Ras guanine-nucleotide exchange factors catalytic domain
 IPR002048  EF-hand domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR020454  Diacylglycerol/phorbol-ester binding
 IPR023578  Ras guanine nucleotide exchange factor domain superfamily
 IPR036964  Ras guanine-nucleotide exchange factor catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway NAS
 biological_processGO:0007202 activation of phospholipase C activity NAS
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0008277 regulation of G-protein coupled receptor protein signaling pathway NAS
 biological_processGO:0008283 cell proliferation IDA
 biological_processGO:0009991 response to extracellular stimulus IDA
 biological_processGO:0030099 myeloid cell differentiation TAS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0046579 positive regulation of Ras protein signal transduction IDA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity IDA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0019992 diacylglycerol binding TAS
 molecular_functionGO:0030742 GTP-dependent protein binding NAS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
FCERI mediated NF-kB activation
RAF/MAP kinase cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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