ENSDARG00000005482


Danio rerio

Features
Gene ID: ENSDARG00000005482
  
Biological name :rapgef2
  
Synonyms : rapgef2 / Rap guanine nucleotide exchange factor (GEF) 2
  
Possible biological names infered from orthology : Q8CHG7 / Q9Y4G8 / Rap guanine nucleotide exchange factor 2
  
Species: Danio rerio
  
Chr. number: 14
Strand: -1
Band:
Gene start: 47779846
Gene end: 48033073
  
Corresponding Affymetrix probe sets: Dr.4032.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000150083
Ensembl peptide - ENSDARP00000155342
Ensembl peptide - ENSDARP00000154651
Ensembl peptide - ENSDARP00000152994
Ensembl peptide - ENSDARP00000004657
Ensembl peptide - ENSDARP00000132401
Ensembl peptide - ENSDARP00000140881
Ensembl peptide - ENSDARP00000146356
Ensembl peptide - ENSDARP00000148424
NCBI entrez gene - 557693     See in Manteia.
swissprot - E7F5Z0
swissprot - A0A0R4IYQ4
swissprot - A0A0R4IBW6
ZFIN ID - ZDB-GENE-030131-6959
Ensembl - ENSDARG00000005482
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RAPGEF2ENSGALG00000020249Gallus gallus
 Q9Y4G8ENSG00000109756Homo sapiens
 Q8CHG7ENSMUSG00000062232Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
si:dkey-253i9.4ENSDARG0000006145963
rapgef6 / Rap guanine nucleotide exchange factor (GEF) 6 / Q8TEU7* / AC008695.1* / Rap guanine nucleotide exchange factor 6*ENSDARG0000001094548
rapgef4 / Rap guanine nucleotide exchange factor (GEF) 4 / Q8WZA2* / Q9EQZ6* / Rap guanine nucleotide exchange factor 4*ENSDARG0000007987216
zgc:171558 / Q8WZA2* / Q9EQZ6* / RAPGEF4* / Rap guanine nucleotide exchange factor 4* / Rap guanine nucleotide exchange factor (GEF) 4*ENSDARG0000007592415
rapgef3 / Rap guanine nucleotide exchange factor (GEF) 3 / Q8VCC8* / O95398* / Rap guanine nucleotide exchange factor 3* / Mus musculus Rap guanine nucleotide exchange factor (GEF) 3 (Rapge...ENSDARG0000007929112
rapgefl1 / Rap guanine nucleotide exchange factor (GEF)-like 1 / Q68EF8* / Q9UHV5* / Rap guanine nucleotide exchange factor like 1*ENSDARG000000799129
rapgef5a / Rap guanine nucleotide exchange factor (GEF) 5a / Q92565* / RAPGEF5* / Rap guanine nucleotide exchange factor 5*ENSDARG000000752719
Q6DBW1 / rasgef1bb / RasGEF domain family, member 1Bb / Q8JZL7* / Q0VAM2* / RASGEF1B* / RasGEF domain family member 1B* / Ras-GEF domain-containing family member 1B *ENSDARG000000442517
Q6DHR3 / rasgef1ba / RasGEF domain family, member 1Ba / Q8JZL7* / Q0VAM2* / RASGEF1B* / RasGEF domain family member 1B* / Ras-GEF domain-containing family member 1B *ENSDARG000000336147
rasgrp3 / RAS guanyl releasing protein 3 (calcium and DAG-regulated) / Q8IV61* / RAS guanyl releasing protein 3*ENSDARG000000778647
rasgrp4 / RAS guanyl releasing protein 4 / Q8BTM9* / Q8TDF6*ENSDARG000000617967
RASGRP2 / RAS guanyl releasing protein 2 / Q7LDG7*ENSDARG000000990925
rasgrp2 / RAS guanyl releasing protein 2 (calcium and DAG-regulated) / Q7LDG7* / Q9QUG9* / RAS guanyl releasing protein 2*ENSDARG000000623285


Protein motifs (from Interpro)
Interpro ID Name
 IPR000159  Ras-associating (RA) domain
 IPR000595  Cyclic nucleotide-binding domain
 IPR000651  Ras-like guanine nucleotide exchange factor, N-terminal
 IPR001478  PDZ domain
 IPR001895  Ras guanine-nucleotide exchange factors catalytic domain
 IPR014710  RmlC-like jelly roll fold
 IPR018490  Cyclic nucleotide-binding-like
 IPR023578  Ras guanine nucleotide exchange factor domain superfamily
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0017034 Rap guanyl-nucleotide exchange factor activity IEA


Pathways (from Reactome)
Pathway description
RAF/MAP kinase cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001557 pronephric glomerulus pronephric glomerulus permeability , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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