ENSGALG00000020249


Gallus gallus

Features
Gene ID: ENSGALG00000020249
  
Biological name :RAPGEF2
  
Synonyms : RAPGEF2 / Rap guanine nucleotide exchange factor 2
  
Possible biological names infered from orthology : Q8CHG7 / Q9Y4G8
  
Species: Gallus gallus
  
Chr. number: 4
Strand: 1
Band:
Gene start: 22207134
Gene end: 22378393
  
Corresponding Affymetrix probe sets: Gga.18298.1.S1_at (Chicken Array)   GgaAffx.20865.1.S1_s_at (Chicken Array)   GgaAffx.22938.1.S1_s_at (Chicken Array)   GgaAffx.22938.2.S1_s_at (Chicken Array)   GgaAffx.22938.3.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000015407
Ensembl peptide - ENSGALP00000056710
Ensembl peptide - ENSGALP00000050941
Ensembl peptide - ENSGALP00000050564
Ensembl peptide - ENSGALP00000050144
NCBI entrez gene - 422418     See in Manteia.
RefSeq - XM_420387
RefSeq - XM_015285324
RefSeq - XM_015285325
RefSeq - XM_015285326
RefSeq - XM_015285327
RefSeq - XM_015285328
RefSeq - XM_004940909
RefSeq - XM_004940910
RefSeq - XM_015285321
RefSeq - XM_015285322
RefSeq - XM_015285323
swissprot - E1BVM2
swissprot - A0A1D5PUV2
swissprot - A0A1D5PDU5
swissprot - A0A1D5PCS3
swissprot - A0A1D5PBL4
Ensembl - ENSGALG00000020249
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rapgef2ENSDARG00000005482Danio rerio
 Q9Y4G8ENSG00000109756Homo sapiens
 Q8CHG7ENSMUSG00000062232Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8TEU7* / RAPGEF6* / AC008695.1* / Rap guanine nucleotide exchange factor 6* / Rap guanine nucleotide exchange factor (GEF) 6*ENSGALG0000002989666
RAPGEF4 / Rap guanine nucleotide exchange factor 4 / Q8WZA2* / Q9EQZ6* / Rap guanine nucleotide exchange factor (GEF) 4*ENSGALG0000004369415
RAPGEF3 / Rap guanine nucleotide exchange factor 3 / O95398* / Q8VCC8* / Mus musculus Rap guanine nucleotide exchange factor (GEF) 3 (Rapgef3), transcript variant 4, mRNA.*ENSGALG0000004377512
RAPGEF5 / Rap guanine nucleotide exchange factor 5 / Q8C0Q9* / Q92565*ENSGALG000000340249
RASGRP3 / RAS guanyl releasing protein 3 / Q8IV61*ENSGALG000000104358
RAPGEFL1 / Rap guanine nucleotide exchange factor like 1 / Q68EF8* / Q9UHV5*ENSGALG000000356907
RASGEF1C / RasGEF domain family member 1C / Q8N431* / Q9D300* / Ras-GEF domain-containing family member 1C *ENSGALG000000060766
RASGRP1 / RAS guanyl releasing protein 1 / O95267* / Q9Z1S3*ENSGALG000000097406
RASGEF1A / RasGEF domain family member 1A / Q8N9B8*ENSGALG000000025255
Q0VAM2* / Q8JZL7* / RASGEF1B* / RasGEF domain family member 1B* / Ras-GEF domain-containing family member 1B *ENSGALG000000109032


Protein motifs (from Interpro)
Interpro ID Name
 IPR000159  Ras-associating (RA) domain
 IPR000595  Cyclic nucleotide-binding domain
 IPR000651  Ras-like guanine nucleotide exchange factor, N-terminal
 IPR001478  PDZ domain
 IPR001895  Ras guanine-nucleotide exchange factors catalytic domain
 IPR014710  RmlC-like jelly roll fold
 IPR018490  Cyclic nucleotide-binding-like
 IPR023578  Ras guanine nucleotide exchange factor domain superfamily
 IPR029071  Ubiquitin-like domain superfamily
 IPR030739  Rap guanine nucleotide exchange factor 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007218 neuropeptide signaling pathway IEA
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0019933 cAMP-mediated signaling IEA
 biological_processGO:0030033 microvillus assembly IEA
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0032486 Rap protein signal transduction IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0043950 positive regulation of cAMP-mediated signaling IEA
 biological_processGO:0045860 positive regulation of protein kinase activity IEA
 biological_processGO:0050774 negative regulation of dendrite morphogenesis IEA
 biological_processGO:0061028 establishment of endothelial barrier IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071320 cellular response to cAMP IEA
 biological_processGO:0071321 cellular response to cGMP IEA
 biological_processGO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway IEA
 biological_processGO:0072659 protein localization to plasma membrane IEA
 biological_processGO:0090557 establishment of endothelial intestinal barrier IEA
 biological_processGO:1901888 regulation of cell junction assembly IEA
 biological_processGO:2000481 positive regulation of cAMP-dependent protein kinase activity IEA
 biological_processGO:2000670 positive regulation of dendritic cell apoptotic process IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030139 endocytic vesicle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0017034 Rap guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0030165 PDZ domain binding IEA
 molecular_functionGO:0030552 cAMP binding IEA
 molecular_functionGO:0031697 beta-1 adrenergic receptor binding IEA
 molecular_functionGO:0050699 WW domain binding IEA
 molecular_functionGO:0070300 phosphatidic acid binding IEA


Pathways (from Reactome)
Pathway description
RAF/MAP kinase cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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