ENSGALG00000010435


Gallus gallus

Features
Gene ID: ENSGALG00000010435
  
Biological name :RASGRP3
  
Synonyms : RASGRP3 / RAS guanyl releasing protein 3
  
Possible biological names infered from orthology : Q8IV61
  
Species: Gallus gallus
  
Chr. number: 3
Strand: -1
Band:
Gene start: 31145552
Gene end: 31183812
  
Corresponding Affymetrix probe sets: Gga.1287.1.S1_at (Chicken Array)   GgaAffx.12948.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000059938
Ensembl peptide - ENSGALP00000016973
NCBI entrez gene - 421460     See in Manteia.
RefSeq - XM_015283719
RefSeq - NM_001006401
RefSeq Peptide - NP_001006401
swissprot - Q5ZID9
swissprot - A0A1L1RMC9
Ensembl - ENSGALG00000010435
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rasgrp3ENSDARG00000077864Danio rerio
 Q8IV61ENSG00000152689Homo sapiens
 Rasgrp3ENSMUSG00000071042Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RASGRP1 / RAS guanyl releasing protein 1 / O95267* / Q9Z1S3*ENSGALG0000000974045
Q8TEU7* / RAPGEF6* / AC008695.1* / Rap guanine nucleotide exchange factor 6* / Rap guanine nucleotide exchange factor (GEF) 6*ENSGALG0000002989618
RAPGEF2 / Rap guanine nucleotide exchange factor 2 / Q8CHG7* / Q9Y4G8*ENSGALG0000002024918
RAPGEF3 / Rap guanine nucleotide exchange factor 3 / O95398* / Q8VCC8* / Mus musculus Rap guanine nucleotide exchange factor (GEF) 3 (Rapgef3), transcript variant 4, mRNA.*ENSGALG0000004377513
RAPGEF4 / Rap guanine nucleotide exchange factor 4 / Q8WZA2* / Q9EQZ6* / Rap guanine nucleotide exchange factor (GEF) 4*ENSGALG0000004369413
RAPGEF5 / Rap guanine nucleotide exchange factor 5 / Q8C0Q9* / Q92565*ENSGALG0000003402412
RASGEF1C / RasGEF domain family member 1C / Q8N431* / Q9D300* / Ras-GEF domain-containing family member 1C *ENSGALG0000000607611
RAPGEFL1 / Rap guanine nucleotide exchange factor like 1 / Q68EF8* / Q9UHV5*ENSGALG0000003569010
RASGEF1A / RasGEF domain family member 1A / Q8N9B8*ENSGALG000000025258
Q0VAM2* / Q8JZL7* / RASGEF1B* / RasGEF domain family member 1B* / Ras-GEF domain-containing family member 1B *ENSGALG000000109034


Protein motifs (from Interpro)
Interpro ID Name
 IPR000651  Ras-like guanine nucleotide exchange factor, N-terminal
 IPR001895  Ras guanine-nucleotide exchange factors catalytic domain
 IPR002048  EF-hand domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site
 IPR020454  Diacylglycerol/phorbol-ester binding
 IPR023578  Ras guanine nucleotide exchange factor domain superfamily
 IPR029645  Ras guanyl-releasing protein 1/3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0007265 Ras protein signal transduction IEA
 biological_processGO:0007268 chemical synaptic transmission IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0032045 guanyl-nucleotide exchange factor complex IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0017016 Ras GTPase binding IEA
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0019992 diacylglycerol binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Activation of RAS in B cells
RAF/MAP kinase cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000030943 KRAS / KRAS proto-oncogene, GTPase / P01116* / P32883* / GTPase KRas GTPase KRas, N-terminally processed*  / reaction
 ENSGALG00000029260 H-RAS / P08642 / GTPase HRas GTPase HRas, N-terminally processed / HRAS* / Q61411* / P01112* / HRas proto-oncogene, GTPase*  / reaction






 

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