Manteia

ENSDARG00000019815

Danio rerio

Features

Gene ID:	ENSDARG00000019815

Biological name :	fn1a

Synonyms :	fibronectin 1a / fn1a

Possible biological names infered from orthology :	fibronectin 1 / Fibronectin Anastellin / FN1 / P02751 / P11276

Species:	Danio rerio

Chr. number:	9
Strand:	-1
Band:
Gene start:	15362300
Gene end:	15424639

Corresponding Affymetrix probe sets:	Dr.12367.1.A1_at (Zebrafish Array) Dr.19965.1.S1_at (Zebrafish Array) Dr.19965.2.S1_a_at (Zebrafish Array) NM_131520_at (Zebrafish Genome Array with custom cdf files)

Cross references:	Ensembl peptide - ENSDARP00000147251 Ensembl peptide - ENSDARP00000112231 NCBI entrez gene - 100005469 See in Manteia. RefSeq - NM_131520 RefSeq - XM_009304503 RefSeq Peptide - NP_571595 swissprot - B0S602 ZFIN ID - ZDB-GENE-000426-1 Ensembl - ENSDARG00000019815

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
FN1	ENSGALG00000003578	Gallus gallus
FN1	ENSG00000115414	Homo sapiens
Fn1	ENSMUSG00000026193	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
fn1b / fibronectin 1b / FN1* / P02751* / P11276* / fibronectin 1* / Fibronectin Anastellin*	ENSDARG00000006526	64
tnc / tenascin C / P24821* / Q80YX1*	ENSDARG00000021948	14
zmp:0000000846 / TNC* / P24821* / tenascin C*	ENSDARG00000078362	13
tnr / tenascin R (restrictin, janusin) / Q8BYI9* / Q92752* / tenascin R*	ENSDARG00000020771	12
tnn / tenascin N / Q80Z71* / Q9UQP3*	ENSDARG00000024829	8
tnxba / tenascin XBa / TNXB* / P22105* / tenascin XB*	ENSDARG00000001760	6
angptl5 / angiopoietin-like 5 / Q86XS5*	ENSDARG00000056630	3
angptl3 / angiopoietin-like 3 / Q9R182* / Q9Y5C1* / Angiopoietin-related protein 3 ANGPTL3(17-224)*	ENSDARG00000044365	3
fgg / fibrinogen gamma chain / P02679* / Q8VCM7*	ENSDARG00000037281	3
angptl4 / angiopoietin-like 4 / Q9BY76* / Q9Z1P8* / Angiopoietin-related protein 4 *	ENSDARG00000035859	3
fgb / fibrinogen beta chain / P02675* / Q8K0E8* / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain*	ENSDARG00000008969	3
fga / fibrinogen alpha chain / E9PV24* / P02671* / Fibrinogen alpha chain Fibrinopeptide A Fibrinogen alpha chain*	ENSDARG00000020741	3
zgc:194887	ENSDARG00000098586	2
si:ch211-287a12.9	ENSDARG00000057004	2
fgl1 / fibrinogen-like 1 / Q08830*	ENSDARG00000105380	2

Protein motifs (from Interpro)

Interpro ID	Name
IPR000083	Fibronectin, type I
IPR000562	Fibronectin type II domain
IPR003961	Fibronectin type III
IPR013783	Immunoglobulin-like fold
IPR013806	Kringle-like fold

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001756	somitogenesis	IMP
biological_process	GO:0001757	somite specification	IGI
biological_process	GO:0002042	cell migration involved in sprouting angiogenesis	IMP
biological_process	GO:0002089	lens morphogenesis in camera-type eye	IMP
biological_process	GO:0003007	heart morphogenesis	IMP
biological_process	GO:0003128	heart field specification	IGI
biological_process	GO:0003146	heart jogging	IMP
biological_process	GO:0003319	cardioblast migration to the midline involved in heart rudiment formation	IGI
biological_process	GO:0007507	heart development	IMP
biological_process	GO:0021591	ventricular system development	IMP
biological_process	GO:0030325	adrenal gland development	IMP
biological_process	GO:0035050	embryonic heart tube development	IMP
biological_process	GO:0045198	establishment of epithelial cell apical/basal polarity	IMP
biological_process	GO:0048703	embryonic viscerocranium morphogenesis	IGI
biological_process	GO:0060956	endocardial cell differentiation	IMP
biological_process	GO:0070309	lens fiber cell morphogenesis	IMP
biological_process	GO:0098609	cell-cell adhesion	IMP
cellular_component	GO:0005576	extracellular region	IEA
cellular_component	GO:0005614	interstitial matrix	IMP
molecular_function	GO:0005178	integrin binding	IGI

Pathways (from Reactome)

Pathway description

Platelet degranulation

Degradation of the extracellular matrix

Extracellular matrix organization

Fibronectin matrix formation

Cell surface interactions at the vascular wall

Molecules associated with elastic fibres

Integrin cell surface interactions

Non-integrin membrane-ECM interactions

ECM proteoglycans

Integrin alphaIIb beta3 signaling

GRB2:SOS provides linkage to MAPK signaling for Integrins

p130Cas linkage to MAPK signaling for integrins

Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

MAP2K and MAPK activation

MET activates PTK2 signaling

Post-translational protein phosphorylation

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
ZFA:0000008	brain	brain quality , abnormal	Show
ZFA:0000014	dorsal aorta	dorsal aorta sprouting angiogenesis process quality , abnormal dorsal aorta increased size , abnormal	Show
ZFA:0000029	hindbrain	hindbrain quality , abnormal hindbrain morphology , abnormal	Show
ZFA:0000035	lens	lens morphology , abnormal lens nucleus increased amount , abnormal lens structure , abnormal lens separated from retina , abnormal lens cell loose , abnormal	Show
ZFA:0000072	somite 1	somite 1 morphology , abnormal	Show
ZFA:0000076	swim bladder	swim bladder decreased size , abnormal	Show
ZFA:0000107	eye	eye decreased size , abnormal	Show
ZFA:0000110	fourth ventricle	fourth ventricle decreased size , abnormal	Show
ZFA:0000114	heart	heart quality , abnormal heart morphology , abnormal	Show
ZFA:0000128	midbrain	midbrain quality , abnormal midbrain morphology , abnormal	Show
ZFA:0000155	somite	somite degenerate , abnormal	Show
ZFA:0000360	heart tube	heart tube straight , abnormal heart tube duplicated , abnormal	Show
ZFA:0000396	nervous system	nervous system quality , abnormal	Show
ZFA:0000728	somite 2	somite 2 morphology , abnormal	Show
ZFA:0000732	somite 3	somite 3 morphology , abnormal	Show
ZFA:0000857	somite 4	somite 4 morphology , abnormal	Show
ZFA:0001094	whole organism	whole organism lethal (sensu genetics) , abnormal whole organism viability , abnormal	Show
ZFA:0001115	trunk	trunk interstitial matrix morphology , abnormal	Show
ZFA:0001205	Meckel s cartilage	Meckels cartilage decreased length , abnormal	Show
ZFA:0001261	ventricular system	ventricular system collapsed , abnormal	Show
ZFA:0001338	intestine	intestine decreased size , abnormal	Show
ZFA:0001345	interrenal gland	interrenal gland steroid biosynthetic process decreased occurrence , abnormal interrenal gland mislocalised , abnormal	Show
ZFA:0001346	interrenal primordium	interrenal primordium left side unfused from interrenal primordium right side, abnormal interrenal primordium cell migration disrupted , abnormal interrenal primordium morphology , abnormal interrenal primordium position , abnormal	Show
ZFA:0001399	palatoquadrate cartilage	palatoquadrate cartilage decreased length , abnormal	Show
ZFA:0001400	ceratohyal cartilage	ceratohyal cartilage decreased length , abnormal	Show
ZFA:0001612	pharyngeal arch 1	pharyngeal arch 1 morphology , abnormal pharyngeal arch 1 embryonic morphogenesis disrupted , abnormal	Show
ZFA:0001683	corneal epithelium	corneal epithelium morphology , abnormal corneal epithelium undulate , abnormal	Show
ZFA:0005028	ventral wall of dorsal aorta	ventral wall of dorsal aorta amount , ameliorated	Show
ZFA:0005035	subintestinal vein	subintestinal vein morphology , abnormal	Show
ZFA:0005801	interrenal vessel	interrenal vessel absent , abnormal	Show
ZFA:0005802	interrenal angiogenic sprout	interrenal angiogenic sprout absent , abnormal	Show
ZFA:0009354	hematopoietic multipotent progenitor cell	hematopoietic multipotent progenitor cell increased accumulation ventral wall of dorsal aorta , ameliorated	Show

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSDARG00000006353	itga5 / integrin, alpha 5 (fibronectin receptor, alpha polypeptide) / P08648* / P11688* / integrin subunit alpha 5* / Integrin alpha-5 Integrin alpha-5 heavy chain Integrin alpha-5 light chain*	/ complex / reaction
ENSDARG00000044968	vcla / vinculin a / VCL* / Q64727* / P18206* / vinculin*	/ complex
ENSDARG00000021948	tnc / tenascin C / P24821* / Q80YX1*	/ reaction / complex
ENSDARG00000008867	rap1b / Q6TEN1 / RAP1B, member of RAS oncogene family / Q99JI6* / P61224* / RAS related protein 1b*	/ reaction / complex
ENSDARG00000071863	itgb1a / integrin, beta 1a / ITGB1* / P05556* / P09055* / Integrin beta-1 * / integrin subunit beta 1*	/ complex / reaction
ENSDARG00000012553	rap1aa / RAP1A, member of RAS oncogene family a / RAP1B* / Q99JI6* / P61224* / RAS related protein 1b* / RAP1B, member of RAS oncogene family*	/ reaction / complex
ENSDARG00000007923	ptpn1 / protein tyrosine phosphatase, non-receptor type 1 / P18031*	/ reaction
ENSDARG00000015156	fbln2 / fibulin 2 / P37889* / P98095*	/ complex / reaction
ENSDARG00000078362	zmp:0000000846 / TNC* / P24821* / tenascin C*	/ reaction / complex
ENSDARG00000006526	fn1b / fibronectin 1b / FN1* / P02751* / P11276* / fibronectin 1* / Fibronectin Anastellin*	/ complex / - / reaction
ENSDARG00000019815	fn1a / fibronectin 1a / FN1* / P02751* / P11276* / fibronectin 1* / Fibronectin Anastellin*	/ - / complex / reaction
ENSDARG00000008186	syk / spleen tyrosine kinase / P43405* / P48025* / spleen associated tyrosine kinase*	/ complex / reaction
ENSDARG00000056525	bcar1 / breast cancer anti-estrogen resistance 1 / Q61140* / P56945* / BCAR1, Cas family scaffolding protein* / Breast cancer anti-estrogen resistance protein 1 *	/ complex / reaction
ENSDARG00000038059	grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*	/ complex / reaction
ENSDARG00000055635	crk / v-crk avian sarcoma virus CT10 oncogene homolog / P46108* / Q64010* / Adapter molecule crk * / CRK proto-oncogene, adaptor protein*	/ complex / reaction
ENSDARG00000105276	grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*	/ reaction / complex
ENSDARG00000008107	src / Q1JPZ3 / v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyr...	/ complex / reaction
ENSDARG00000067996	csk / C-terminal Src kinase / P41240* / P41241* / Tyrosine-protein kinase CSK *	/ complex / reaction
ENSDARG00000087346	rap1ab / RAP1A, member of RAS oncogene family b / RAP1B* / Q99JI6* / P61224* / RAS related protein 1b* / RAP1B, member of RAS oncogene family*	/ reaction / complex
ENSDARG00000100729	tln1 / talin 1 / P26039* / Q9Y490*	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr