ENSDARG00000021948


Danio rerio

Features
Gene ID: ENSDARG00000021948
  
Biological name :tnc
  
Synonyms : tenascin C / tnc
  
Possible biological names infered from orthology : P24821 / Q80YX1
  
Species: Danio rerio
  
Chr. number: 5
Strand: -1
Band:
Gene start: 28560847
Gene end: 28679135
  
Corresponding Affymetrix probe sets: Dr.9638.1.A1_a_at (Zebrafish Array)   Dr.9638.1.S1_a_at (Zebrafish Array)   NM_130907_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000114191
Ensembl peptide - ENSDARP00000010247
Ensembl peptide - ENSDARP00000146747
Ensembl peptide - ENSDARP00000154936
Ensembl peptide - ENSDARP00000116907
Ensembl peptide - ENSDARP00000144742
NCBI entrez gene - 30037     See in Manteia.
RefSeq - XM_017356031
RefSeq - XM_017356032
RefSeq - XM_021475994
RefSeq - NM_001312916
RefSeq - NM_130907
RefSeq Peptide - NP_001299845
RefSeq Peptide - NP_570982
swissprot - F1R5T0
swissprot - E9QHI1
swissprot - F1QYE2
ZFIN ID - ZDB-GENE-980526-104
Ensembl - ENSDARG00000021948
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TNCENSGALG00000039990Gallus gallus
 TNCENSG00000041982Homo sapiens
 TncENSMUSG00000028364Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
zmp:0000000846 / TNC* / P24821* / tenascin C*ENSDARG0000007836254
tnr / tenascin R (restrictin, janusin) / Q8BYI9* / Q92752* / tenascin R*ENSDARG0000002077132
tnn / tenascin N / Q80Z71* / Q9UQP3*ENSDARG0000002482920
fn1a / fibronectin 1a / FN1* / P02751* / P11276* / fibronectin 1* / Fibronectin Anastellin*ENSDARG0000001981519
fn1b / fibronectin 1b / FN1* / P02751* / P11276* / fibronectin 1* / Fibronectin Anastellin*ENSDARG0000000652618
tnxba / tenascin XBa / TNXB* / P22105* / tenascin XB*ENSDARG0000000176018
fga / fibrinogen alpha chain / E9PV24* / P02671* / Fibrinogen alpha chain Fibrinopeptide A Fibrinogen alpha chain*ENSDARG000000207417
fgb / fibrinogen beta chain / P02675* / Q8K0E8* / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain*ENSDARG000000089696
fgl1 / fibrinogen-like 1 / Q08830*ENSDARG000001053806
angptl3 / angiopoietin-like 3 / Q9R182* / Q9Y5C1* / Angiopoietin-related protein 3 ANGPTL3(17-224)*ENSDARG000000443656
fgg / fibrinogen gamma chain / P02679* / Q8VCM7*ENSDARG000000372816
angptl4 / angiopoietin-like 4 / Q9BY76* / Q9Z1P8* / Angiopoietin-related protein 4 *ENSDARG000000358596
angptl5 / angiopoietin-like 5 / Q86XS5*ENSDARG000000566305
si:ch211-287a12.9ENSDARG000000570045
zgc:194887ENSDARG000000985864


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR002181  Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
 IPR003961  Fibronectin type III
 IPR013032  EGF-like, conserved site
 IPR013111  EGF-like domain, extracellular
 IPR013783  Immunoglobulin-like fold
 IPR014715  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
 IPR014716  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
 IPR033078  Tenascin-C


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001755 neural crest cell migration IEP
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0007413 axonal fasciculation IMP
 biological_processGO:0007498 mesoderm development IEP
 biological_processGO:0014814 axon regeneration at neuromuscular junction IMP
 biological_processGO:0021554 optic nerve development IMP
 biological_processGO:0030517 negative regulation of axon extension IMP
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0045887 positive regulation of synaptic growth at neuromuscular junction IMP
 biological_processGO:0048680 positive regulation of axon regeneration IMP
 cellular_componentGO:0031012 extracellular matrix IEA


Pathways (from Reactome)
Pathway description
Integrin cell surface interactions
ECM proteoglycans
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000094 blood island blood island nucleate erythrocyte aggregated , abnormal
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 ZFA:0000543 medial longitudinal fasciculus medial longitudinal fasciculus axon decreased amount , abnormal
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 ZFA:0001094 whole organism whole organism movement quality , abnormal
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 ZFA:0001114 head head decreased position , abnormal
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 ZFA:0009052 motor neuron motor neuron axon truncated , abnormal
motor neuron axon defasciculated , abnormal
motor neuron axon increased branchiness , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000032435 itga9 / integrin, alpha 9 / Q13797* / integrin subunit alpha 9*  / reaction / complex
 ENSDARG00000019815 fn1a / fibronectin 1a / FN1* / P02751* / P11276* / fibronectin 1* / Fibronectin Anastellin*  / reaction / complex
 ENSDARG00000071863 itgb1a / integrin, beta 1a / ITGB1* / P05556* / P09055* / Integrin beta-1 * / integrin subunit beta 1*  / reaction / complex
 ENSDARG00000021948 tnc / tenascin C / P24821* / Q80YX1*  / complex
 ENSDARG00000078362 zmp:0000000846 / TNC* / P24821* / tenascin C*  / complex
 ENSDARG00000006526 fn1b / fibronectin 1b / FN1* / P02751* / P11276* / fibronectin 1* / Fibronectin Anastellin*  / complex / reaction






 

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