ENSG00000041982


Homo sapiens

Features
Gene ID: ENSG00000041982
  
Biological name :TNC
  
Synonyms : P24821 / tenascin C / TNC
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: -1
Band: q33.1
Gene start: 115019578
Gene end: 115118257
  
Corresponding Affymetrix probe sets: 201645_at (Human Genome U133 Plus 2.0 Array)   216005_at (Human Genome U133 Plus 2.0 Array)   237169_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000443478
Ensembl peptide - ENSP00000443469
Ensembl peptide - ENSP00000445380
Ensembl peptide - ENSP00000489385
Ensembl peptide - ENSP00000265131
Ensembl peptide - ENSP00000339553
Ensembl peptide - ENSP00000411406
Ensembl peptide - ENSP00000438152
Ensembl peptide - ENSP00000442242
NCBI entrez gene - 3371     See in Manteia.
OMIM - 187380
RefSeq - XM_017014681
RefSeq - XM_006717101
RefSeq - XM_011518625
RefSeq - XM_011518626
RefSeq - XM_011518628
RefSeq - XM_011518629
RefSeq - XM_017014678
RefSeq - XM_017014679
RefSeq - XM_017014680
RefSeq - NM_002160
RefSeq - XM_005251972
RefSeq - XM_005251973
RefSeq - XM_005251974
RefSeq - XM_005251975
RefSeq - XM_006717096
RefSeq - XM_006717097
RefSeq - XM_006717098
RefSeq Peptide - NP_002151
swissprot - F5H5D6
swissprot - F5H7V9
swissprot - H0YGZ3
swissprot - J3QSU6
swissprot - A0A0U1RR80
swissprot - E9PC84
swissprot - P24821
Ensembl - ENSG00000041982
  
Related genetic diseases (OMIM): 615629 - Deafness, autosomal dominant 56, 615629
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tncENSDARG00000021948Danio rerio
 zmp:0000000846ENSDARG00000078362Danio rerio
 TNCENSGALG00000039990Gallus gallus
 TncENSMUSG00000028364Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TNR / Q92752 / tenascin RENSG0000011614728
TNN / Q9UQP3 / tenascin NENSG0000012033221
FN1 / P02751 / fibronectin 1ENSG0000011541418
TNXB / P22105 / tenascin XBENSG0000016847711
FGA / P02671 / fibrinogen alpha chainENSG000001715608
FGL1 / Q08830 / fibrinogen like 1ENSG000001047605
FGB / P02675 / fibrinogen beta chainENSG000001715645
FGG / P02679 / fibrinogen gamma chainENSG000001715575
Q9Y5C1 / ANGPTL3 / angiopoietin like 3ENSG000001328555
Q9BY76 / ANGPTL4 / angiopoietin like 4ENSG000001677724
Q86XS5 / ANGPTL5 / angiopoietin like 5ENSG000001871514


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR002181  Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
 IPR003961  Fibronectin type III
 IPR013032  EGF-like, conserved site
 IPR013111  EGF-like domain, extracellular
 IPR013783  Immunoglobulin-like fold
 IPR014715  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
 IPR014716  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
 IPR033078  Tenascin-C
 IPR036056  Fibrinogen-like, C-terminal
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001649 osteoblast differentiation HDA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007162 negative regulation of cell adhesion IEA
 biological_processGO:0007528 neuromuscular junction development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0009611 response to wounding IEP
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0014012 peripheral nervous system axon regeneration IEA
 biological_processGO:0030198 extracellular matrix organization TAS
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IEA
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0060447 bud outgrowth involved in lung branching IEA
 biological_processGO:0060739 mesenchymal-epithelial cell signaling involved in prostate gland development IEA
 biological_processGO:0060740 prostate gland epithelium morphogenesis IEA
 biological_processGO:0071300 cellular response to retinoic acid IEA
 biological_processGO:0071305 cellular response to vitamin D IEA
 biological_processGO:0071774 response to fibroblast growth factor IEA
 biological_processGO:0071799 cellular response to prostaglandin D stimulus IEA
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005604 basement membrane IEA
 cellular_componentGO:0005614 interstitial matrix IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0045545 syndecan binding IDA


Pathways (from Reactome)
Pathway description
Integrin cell surface interactions
Syndecan interactions
ECM proteoglycans
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000006 Autosomal dominant inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." [HPO:curators]
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 HP:0000365 Hearing loss 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000144668 ITGA9 / Q13797 / integrin subunit alpha 9  / reaction / complex
 ENSG00000150093 ITGB1 / P05556 / integrin subunit beta 1  / complex / reaction
 ENSG00000259207 ITGB3 / P05106 / integrin subunit beta 3  / complex / reaction
 ENSG00000077943 ITGA8 / P53708 / integrin subunit alpha 8  / complex / reaction
 ENSG00000138448 ITGAV / P06756 / integrin subunit alpha V  / complex / reaction
 ENSG00000041982 TNC / P24821 / tenascin C  / complex
 ENSG00000115414 FN1 / P02751 / fibronectin 1  / complex / reaction






 

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