ENSG00000138448


Homo sapiens

Features
Gene ID: ENSG00000138448
  
Biological name :ITGAV
  
Synonyms : integrin subunit alpha V / ITGAV / P06756
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q32.1
Gene start: 186590065
Gene end: 186680901
  
Corresponding Affymetrix probe sets: 202351_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000261023
Ensembl peptide - ENSP00000364042
Ensembl peptide - ENSP00000389442
Ensembl peptide - ENSP00000404291
NCBI entrez gene - 3685     See in Manteia.
OMIM - 193210
RefSeq - NM_001144999
RefSeq - NM_002210
RefSeq - NM_001145000
RefSeq Peptide - NP_001138471
RefSeq Peptide - NP_002201
RefSeq Peptide - NP_001138472
swissprot - P06756
swissprot - H7BZG1
swissprot - L7RXH0
Ensembl - ENSG00000138448
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itgavENSDARG00000006314Danio rerio
 ITGAVENSGALG00000002655Gallus gallus
 ItgavENSMUSG00000027087Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ITGA8 / P53708 / integrin subunit alpha 8ENSG0000007794348
ITGA5 / P08648 / integrin subunit alpha 5ENSG0000016163845
ITGA2B / P08514 / integrin subunit alpha 2bENSG0000000596137
ITGA7 / Q13683 / integrin subunit alpha 7ENSG0000013542429
ITGA6 / P23229 / integrin subunit alpha 6ENSG0000009140928
ITGA9 / Q13797 / integrin subunit alpha 9ENSG0000014466825
ITGA3 / P26006 / integrin subunit alpha 3ENSG0000000588425
ITGA4 / P13612 / integrin subunit alpha 4ENSG0000011523225
ITGA2 / P17301 / integrin subunit alpha 2ENSG0000016417122
ITGA11 / Q9UKX5 / integrin subunit alpha 11ENSG0000013780921
ITGAM / P11215 / integrin subunit alpha MENSG0000016989621
ITGAX / P20702 / integrin subunit alpha XENSG0000014067821
ITGAD / Q13349 / integrin subunit alpha DENSG0000015688621
ITGA1 / P56199 / integrin subunit alpha 1ENSG0000021394921
ITGA10 / O75578 / integrin subunit alpha 10ENSG0000014312721
ITGAE / P38570 / integrin subunit alpha EENSG0000008345720
ITGAL / P20701 / integrin subunit alpha LENSG0000000584420


Protein motifs (from Interpro)
Interpro ID Name
 IPR000413  Integrin alpha chain
 IPR013517  FG-GAP repeat
 IPR013519  Integrin alpha beta-propellor
 IPR013649  Integrin alpha-2
 IPR018184  Integrin alpha chain, C-terminal cytoplasmic region, conserved site
 IPR032695  Integrin domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEP
 biological_processGO:0001568 blood vessel development IEA
 biological_processGO:0001570 vasculogenesis IEA
 biological_processGO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS
 biological_processGO:0006874 cellular calcium ion homeostasis IEA
 biological_processGO:0007155 cell adhesion IDA
 biological_processGO:0007160 cell-matrix adhesion NAS
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007229 integrin-mediated signaling pathway NAS
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0010745 negative regulation of macrophage derived foam cell differentiation IMP
 biological_processGO:0010888 negative regulation of lipid storage IMP
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0030198 extracellular matrix organization TAS
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0031589 cell-substrate adhesion IMP
 biological_processGO:0032369 negative regulation of lipid transport IMP
 biological_processGO:0033627 cell adhesion mediated by integrin IDA
 biological_processGO:0033690 positive regulation of osteoblast proliferation IEA
 biological_processGO:0034113 heterotypic cell-cell adhesion IMP
 biological_processGO:0034446 substrate adhesion-dependent cell spreading IDA
 biological_processGO:0035987 endodermal cell differentiation IMP
 biological_processGO:0038027 apolipoprotein A-I-mediated signaling pathway IMP
 biological_processGO:0038044 transforming growth factor-beta secretion IEA
 biological_processGO:0043277 apoptotic cell clearance ISS
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process IMP
 biological_processGO:0045785 positive regulation of cell adhesion IDA
 biological_processGO:0046718 viral entry into host cell TAS
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway TAS
 biological_processGO:0050748 negative regulation of lipoprotein metabolic process IMP
 biological_processGO:0050764 regulation of phagocytosis IDA
 biological_processGO:0050900 leukocyte migration TAS
 biological_processGO:0050919 negative chemotaxis IMP
 biological_processGO:0052066 entry of symbiont into host cell by promotion of host phagocytosis NAS
 biological_processGO:0070371 ERK1 and ERK2 cascade ISS
 biological_processGO:0070588 calcium ion transmembrane transport IDA
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand ISS
 biological_processGO:2000536 negative regulation of entry of bacterium into host cell IDA
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IMP
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0005925 focal adhesion IDA
 cellular_componentGO:0008305 integrin complex NAS
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface HDA
 cellular_componentGO:0016020 membrane ISS
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031258 lamellipodium membrane IDA
 cellular_componentGO:0031527 filopodium membrane IDA
 cellular_componentGO:0031528 microvillus membrane IDA
 cellular_componentGO:0032587 ruffle membrane IDA
 cellular_componentGO:0034683 integrin alphav-beta3 complex IDA
 cellular_componentGO:0034684 integrin alphav-beta5 complex IDA
 cellular_componentGO:0034685 integrin alphav-beta6 complex IEA
 cellular_componentGO:0034686 integrin alphav-beta8 complex IDA
 cellular_componentGO:0035579 specific granule membrane TAS
 cellular_componentGO:0035866 alphav-beta3 integrin-PKCalpha complex NAS
 cellular_componentGO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex IDA
 cellular_componentGO:0035868 alphav-beta3 integrin-HMGB1 complex IDA
 cellular_componentGO:0045335 phagocytic vesicle TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0001618 virus receptor activity IEA
 molecular_functionGO:0001846 opsonin binding ISS
 molecular_functionGO:0001968 fibronectin binding IDA
 molecular_functionGO:0002020 protease binding IDA
 molecular_functionGO:0005080 protein kinase C binding ISS
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005178 integrin binding IPI
 molecular_functionGO:0005245 voltage-gated calcium channel activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015026 coreceptor activity TAS
 molecular_functionGO:0017134 fibroblast growth factor binding IDA
 molecular_functionGO:0019960 C-X3-C chemokine binding IDA
 molecular_functionGO:0031994 insulin-like growth factor I binding IDA
 molecular_functionGO:0038132 neuregulin binding IDA
 molecular_functionGO:0042277 peptide binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050431 transforming growth factor beta binding ISS
 molecular_functionGO:0050840 extracellular matrix binding IDA
 molecular_functionGO:1990430 extracellular matrix protein binding IDA


Pathways (from Reactome)
Pathway description
Cross-presentation of particulate exogenous antigens (phagosomes)
Elastic fibre formation
PECAM1 interactions
Molecules associated with elastic fibres
Integrin cell surface interactions
Laminin interactions
Syndecan interactions
ECM proteoglycans
VEGFA-VEGFR2 Pathway
Signal transduction by L1
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000105664 COMP / P49747 / cartilage oligomeric matrix protein  / reaction / complex
 ENSG00000109072 VTN / P04004 / vitronectin  / complex / reaction
 ENSG00000105855 ITGB8 / P26012 / integrin subunit beta 8  / complex
 ENSG00000112715 VEGFA / P15692 / vascular endothelial growth factor A  / complex / reaction
 ENSG00000118785 SPP1 / P10451 / secreted phosphoprotein 1  / reaction / complex
 ENSG00000128052 KDR / P35968 / kinase insert domain receptor  / reaction / complex
 ENSG00000188157 AGRN / agrin / O00468  / reaction / complex
 ENSG00000169398 PTK2 / Q05397 / protein tyrosine kinase 2  / reaction
 ENSG00000082781 ITGB5 / P18084 / integrin subunit beta 5  / complex
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / reaction
 ENSG00000152591 DSPP / Q9NZW4 / dentin sialophosphoprotein  / complex / reaction
 ENSG00000120899 PTK2B / Q14289 / protein tyrosine kinase 2 beta  / complex / reaction
 ENSG00000150093 ITGB1 / P05556 / integrin subunit beta 1  / complex
 ENSG00000166147 FBN1 / P35555 / fibrillin 1  / complex / reaction
 ENSG00000029559 IBSP / P21815 / integrin binding sialoprotein  / reaction / complex
 ENSG00000080824 P07900 / HSP90AA1 / heat shock protein 90 alpha family class A member 1  / reaction
 ENSG00000107338 SHB / Q15464 / SH2 domain containing adaptor protein B  / reaction
 ENSG00000110799 VWF / P04275 / von Willebrand factor  / complex / reaction
 ENSG00000115221 ITGB6 / P18564 / integrin subunit beta 6  / complex
 ENSG00000152592 DMP1 / Q13316 / dentin matrix acidic phosphoprotein 1  / reaction / complex
 ENSG00000041982 TNC / P24821 / tenascin C  / reaction / complex
 ENSG00000259207 ITGB3 / P05106 / integrin subunit beta 3  / complex






 

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