Manteia

ENSG00000109072

Homo sapiens

Features

Gene ID:	ENSG00000109072

Biological name :	VTN

Synonyms :	P04004 / vitronectin / VTN

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	17
Strand:	-1
Band:	q11.2
Gene start:	28367276
Gene end:	28373091

Corresponding Affymetrix probe sets:	204534_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000226218 Ensembl peptide - ENSP00000440439 NCBI entrez gene - 7448 See in Manteia. OMIM - 193190 RefSeq - NM_000638 RefSeq Peptide - NP_000629 swissprot - D9ZGG2 swissprot - F5GX75 swissprot - P04004 Ensembl - ENSG00000109072

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
vtna	ENSDARG00000055388	Danio rerio
vtnb	ENSDARG00000053831	Danio rerio
VTN	ENSGALG00000003589	Gallus gallus
Vtn	ENSMUSG00000017344	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
PRG4 / Q92954 / proteoglycan 4	ENSG00000116690	24
AC002094.3	ENSG00000273171	11

Protein motifs (from Interpro)

Interpro ID	Name
IPR000585	Hemopexin-like domain
IPR001212	Somatomedin B domain
IPR018486	Hemopexin, conserved site
IPR018487	Hemopexin-like repeats
IPR020436	Somatomedin B, chordata
IPR036024	Somatomedin B-like domain superfamily
IPR036375	Hemopexin-like domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006898	receptor-mediated endocytosis	IEA
biological_process	GO:0006955	immune response	IEA
biological_process	GO:0007155	cell adhesion	TAS
biological_process	GO:0007160	cell-matrix adhesion	IDA
biological_process	GO:0008283	cell proliferation	IGI
biological_process	GO:0010811	positive regulation of cell-substrate adhesion	IEA
biological_process	GO:0010951	negative regulation of endopeptidase activity	IDA
biological_process	GO:0014911	positive regulation of smooth muscle cell migration	IDA
biological_process	GO:0016477	cell migration	IGI
biological_process	GO:0030195	negative regulation of blood coagulation	IC
biological_process	GO:0030198	extracellular matrix organization	TAS
biological_process	GO:0030449	regulation of complement activation	TAS
biological_process	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	TAS
biological_process	GO:0032092	positive regulation of protein binding	IDA
biological_process	GO:0033627	cell adhesion mediated by integrin	IDA
biological_process	GO:0035987	endodermal cell differentiation	IDA
biological_process	GO:0048260	positive regulation of receptor-mediated endocytosis	IDA
biological_process	GO:0048709	oligodendrocyte differentiation	IEA
biological_process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IDA
biological_process	GO:0051258	protein polymerization	IEA
biological_process	GO:0061302	smooth muscle cell-matrix adhesion	IDA
biological_process	GO:0090303	positive regulation of wound healing	IC
biological_process	GO:0097421	liver regeneration	IEA
cellular_component	GO:0005576	extracellular region	IDA
cellular_component	GO:0005604	basement membrane	IEA
cellular_component	GO:0005615	extracellular space	TAS
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005783	endoplasmic reticulum	IDA
cellular_component	GO:0005796	Golgi lumen	IEA
cellular_component	GO:0031012	extracellular matrix	IEA
cellular_component	GO:0043231	intracellular membrane-bounded organelle	IDA
cellular_component	GO:0048237	rough endoplasmic reticulum lumen	IEA
cellular_component	GO:0070062	extracellular exosome	HDA
cellular_component	GO:0071062	alphav-beta3 integrin-vitronectin complex	TAS
cellular_component	GO:0072562	blood microparticle	HDA
molecular_function	GO:0005044	scavenger receptor activity	IEA
molecular_function	GO:0005178	integrin binding	IPI
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0005518	collagen binding	IEA
molecular_function	GO:0008201	heparin binding	IEA
molecular_function	GO:0030247	polysaccharide binding	IEA
molecular_function	GO:0042802	identical protein binding	IEA
molecular_function	GO:0050840	extracellular matrix binding	IEA

Pathways (from Reactome)

Pathway description

Molecules associated with elastic fibres

Integrin cell surface interactions

Syndecan interactions

ECM proteoglycans

Regulation of Complement cascade

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000138448	ITGAV / P06756 / integrin subunit alpha V	/ complex / reaction
ENSG00000082781	ITGB5 / P18084 / integrin subunit beta 5	/ complex / reaction
ENSG00000039537	C6 / P13671 / complement C6	/ reaction / complex
ENSG00000112936	C7 / P10643 / complement C7	/ complex / reaction
ENSG00000113600	C9 / P02748 / complement C9	/ reaction / complex
ENSG00000021852	C8B / P07358 / complement C8 beta chain	/ complex / reaction
ENSG00000106804	C5 / P01031 / complement C5	/ complex / reaction
ENSG00000259207	ITGB3 / P05106 / integrin subunit beta 3	/ reaction / complex
ENSG00000106366	P05121 / SERPINE1 / serpin family E member 1	/ reaction / complex
ENSG00000105855	ITGB8 / P26012 / integrin subunit beta 8	/ complex / reaction
ENSG00000150093	ITGB1 / P05556 / integrin subunit beta 1	/ complex / reaction
ENSG00000157131	C8A / P07357 / complement C8 alpha chain	/ complex / reaction
ENSG00000176919	C8G / P07360 / complement C8 gamma chain	/ complex / reaction
ENSG00000005961	ITGA2B / P08514 / integrin subunit alpha 2b	/ reaction / complex
ENSG00000049540	ELN / P15502 / elastin	/ complex / reaction
ENSG00000138829	FBN2 / P35556 / fibrillin 2	/ complex / reaction
ENSG00000166147	FBN1 / P35555 / fibrillin 1	/ complex / reaction
ENSG00000197614	MFAP5 / Q13361 / microfibril associated protein 5	/ complex / reaction
ENSG00000117122	MFAP2 / P55001 / microfibril associated protein 2	/ reaction / complex
ENSG00000138080	Q9Y6C2 / EMILIN1 / elastin microfibril interfacer 1	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr