ENSG00000105855


Homo sapiens

Features
Gene ID: ENSG00000105855
  
Biological name :ITGB8
  
Synonyms : integrin subunit beta 8 / ITGB8 / P26012
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: p21.1
Gene start: 20330702
Gene end: 20415754
  
Corresponding Affymetrix probe sets: 1563010_at (Human Genome U133 Plus 2.0 Array)   205816_at (Human Genome U133 Plus 2.0 Array)   211488_s_at (Human Genome U133 Plus 2.0 Array)   226189_at (Human Genome U133 Plus 2.0 Array)   242982_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000222573
Ensembl peptide - ENSP00000441561
NCBI entrez gene - 3696     See in Manteia.
OMIM - 604160
RefSeq - XM_017012183
RefSeq - NM_002214
RefSeq - XM_017012181
RefSeq - XM_017012182
RefSeq - XM_011515393
RefSeq - XM_011515394
RefSeq - XM_011515396
RefSeq - XM_017012178
RefSeq - XM_017012179
RefSeq - XM_017012180
RefSeq Peptide - NP_002205
swissprot - P26012
Ensembl - ENSG00000105855
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itgb8ENSDARG00000028222Danio rerio
 ITGB8ENSGALG00000010875Gallus gallus
 Itgb8ENSMUSG00000025321Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ITGB6 / P18564 / integrin subunit beta 6ENSG0000011522135
AC068234.1ENSG0000025975334
ITGB3 / P05106 / integrin subunit beta 3ENSG0000025920734
ITGB5 / P18084 / integrin subunit beta 5ENSG0000008278134
ITGB1 / P05556 / integrin subunit beta 1ENSG0000015009333
ITGB2 / P05107 / integrin subunit beta 2ENSG0000016025531
ITGB7 / P26010 / integrin subunit beta 7ENSG0000013962630
ITGB4 / P16144 / integrin subunit beta 4ENSG0000013247028
ITGBL1 / O95965 / integrin subunit beta like 1ENSG0000019854214


Protein motifs (from Interpro)
Interpro ID Name
 IPR002369  Integrin beta subunit, VWA domain
 IPR013032  EGF-like, conserved site
 IPR013111  EGF-like domain, extracellular
 IPR015442  Integrin beta-8 subunit
 IPR015812  Integrin beta subunit
 IPR016201  PSI domain
 IPR032695  Integrin domain superfamily
 IPR033760  Integrin beta N-terminal
 IPR036465  von Willebrand factor A-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001573 ganglioside metabolic process IEA
 biological_processGO:0007155 cell adhesion TAS
 biological_processGO:0007160 cell-matrix adhesion IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0030198 extracellular matrix organization TAS
 biological_processGO:0045766 positive regulation of angiogenesis IMP
 biological_processGO:0051216 cartilage development IMP
 biological_processGO:0060674 placenta blood vessel development TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0008305 integrin complex TAS
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0034686 integrin alphav-beta8 complex IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:1990430 extracellular matrix protein binding IDA


Pathways (from Reactome)
Pathway description
Molecules associated with elastic fibres
Integrin cell surface interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000109072 VTN / P04004 / vitronectin  / complex / reaction
 ENSG00000138448 ITGAV / P06756 / integrin subunit alpha V  / complex






 

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