ENSG00000160255


Homo sapiens

Features
Gene ID: ENSG00000160255
  
Biological name :ITGB2
  
Synonyms : integrin subunit beta 2 / ITGB2 / P05107
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 21
Strand: -1
Band: q22.3
Gene start: 44885953
Gene end: 44931989
  
Corresponding Affymetrix probe sets: 1555349_a_at (Human Genome U133 Plus 2.0 Array)   202803_s_at (Human Genome U133 Plus 2.0 Array)   236988_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000380948
Ensembl peptide - ENSP00000430901
Ensembl peptide - ENSP00000429683
Ensembl peptide - ENSP00000428979
Ensembl peptide - ENSP00000428870
Ensembl peptide - ENSP00000428503
Ensembl peptide - ENSP00000428434
Ensembl peptide - ENSP00000428413
Ensembl peptide - ENSP00000428125
Ensembl peptide - ENSP00000427732
Ensembl peptide - ENSP00000380955
Ensembl peptide - ENSP00000380952
Ensembl peptide - ENSP00000380950
Ensembl peptide - ENSP00000303242
Ensembl peptide - ENSP00000317697
Ensembl peptide - ENSP00000347279
Ensembl peptide - ENSP00000380944
NCBI entrez gene - 3689     See in Manteia.
OMIM - 600065
RefSeq - XM_017028341
RefSeq - NM_000211
RefSeq - NM_001127491
RefSeq - NM_001303238
RefSeq - XM_006724001
RefSeq Peptide - NP_000202
RefSeq Peptide - NP_001120963
RefSeq Peptide - NP_001290167
swissprot - D3DSM0
swissprot - A8MVG7
swissprot - E5RK54
swissprot - J3KNI6
swissprot - P05107
swissprot - E7EVZ9
swissprot - E5RK25
swissprot - E5RIG7
swissprot - E5RIE4
swissprot - E5RHE6
swissprot - E5RHT0
swissprot - E5RGK9
swissprot - E5RFI0
Ensembl - ENSG00000160255
  
Related genetic diseases (OMIM): 116920 - Leukocyte adhesion deficiency, 116920
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itgb2ENSDARG00000016939Danio rerio
 ITGB2ENSGALG00000007511Gallus gallus
 Itgb2ENSMUSG00000000290Mus musculus
 Itgb2lENSMUSG00000000157Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ITGB7 / P26010 / integrin subunit beta 7ENSG0000013962648
ITGB1 / P05556 / integrin subunit beta 1ENSG0000015009346
ITGB3 / P05106 / integrin subunit beta 3ENSG0000025920739
AC068234.1ENSG0000025975338
ITGB5 / P18084 / integrin subunit beta 5ENSG0000008278138
ITGB6 / P18564 / integrin subunit beta 6ENSG0000011522137
ITGB4 / P16144 / integrin subunit beta 4ENSG0000013247033
ITGB8 / P26012 / integrin subunit beta 8ENSG0000010585531
ITGBL1 / O95965 / integrin subunit beta like 1ENSG0000019854217


Protein motifs (from Interpro)
Interpro ID Name
 IPR002369  Integrin beta subunit, VWA domain
 IPR012896  Integrin beta subunit, tail
 IPR014836  Integrin beta subunit, cytoplasmic domain
 IPR015439  Integrin beta-2 subunit
 IPR015812  Integrin beta subunit
 IPR016201  PSI domain
 IPR021157  Cytochrome c1, transmembrane anchor, C-terminal
 IPR032695  Integrin domain superfamily
 IPR033760  Integrin beta N-terminal
 IPR036349  Integrin beta tail domain superfamily
 IPR036465  von Willebrand factor A-like domain superfamily
 IPR037076  Integrin beta subunit, cytoplasmic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002523 leukocyte migration involved in inflammatory response IEA
 biological_processGO:0006909 phagocytosis IEA
 biological_processGO:0006911 phagocytosis, engulfment ISS
 biological_processGO:0006915 apoptotic process NAS
 biological_processGO:0006954 inflammatory response NAS
 biological_processGO:0007155 cell adhesion TAS
 biological_processGO:0007159 leukocyte cell-cell adhesion IDA
 biological_processGO:0007160 cell-matrix adhesion IMP
 biological_processGO:0007229 integrin-mediated signaling pathway TAS
 biological_processGO:0007267 cell-cell signaling NAS
 biological_processGO:0007568 aging IEA
 biological_processGO:0008360 regulation of cell shape NAS
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0030101 natural killer cell activation IEA
 biological_processGO:0030198 extracellular matrix organization TAS
 biological_processGO:0030593 neutrophil chemotaxis IDA
 biological_processGO:0031623 receptor internalization ISS
 biological_processGO:0032930 positive regulation of superoxide anion generation IGI
 biological_processGO:0034113 heterotypic cell-cell adhesion IMP
 biological_processGO:0034142 toll-like receptor 4 signaling pathway TAS
 biological_processGO:0035987 endodermal cell differentiation IEP
 biological_processGO:0043113 receptor clustering IMP
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0043315 positive regulation of neutrophil degranulation IGI
 biological_processGO:0043542 endothelial cell migration IEA
 biological_processGO:0045123 cellular extravasation IEA
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0050730 regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0050776 regulation of immune response TAS
 biological_processGO:0050900 leukocyte migration TAS
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0071404 cellular response to low-density lipoprotein particle stimulus ISS
 biological_processGO:0097242 amyloid-beta clearance ISS
 biological_processGO:0098609 cell-cell adhesion IEA
 biological_processGO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules NAS
 biological_processGO:1990266 neutrophil migration IMP
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0008305 integrin complex NAS
 cellular_componentGO:0009897 external side of plasma membrane NAS
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0034687 integrin alphaL-beta2 complex IDA
 cellular_componentGO:0034688 integrin alphaM-beta2 complex NAS
 cellular_componentGO:0035579 specific granule membrane TAS
 cellular_componentGO:0043235 receptor complex IDA
 cellular_componentGO:0044853 plasma membrane raft IDA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0070821 tertiary granule membrane TAS
 cellular_componentGO:0099568 cytoplasmic region IPI
 cellular_componentGO:0101003 ficolin-1-rich granule membrane TAS
 cellular_componentGO:1903561 extracellular vesicle HDA
 molecular_functionGO:0001540 amyloid-beta binding ISS
 molecular_functionGO:0001851 complement component C3b binding ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0030369 ICAM-3 receptor activity IMP
 molecular_functionGO:0031072 heat shock protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity NAS
 molecular_functionGO:0050839 cell adhesion molecule binding IMP


Pathways (from Reactome)
Pathway description
Toll Like Receptor 4 (TLR4) Cascade
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Cell surface interactions at the vascular wall
Integrin cell surface interactions
Interleukin-4 and Interleukin-13 signaling
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
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 HP:0000230 Gingivitis 
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 HP:0000704 Periodontal disease 
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 HP:0001974 Leukocytosis "An abnormal increase in the number of `leukocytes` (CL:0000738) in the `blood` (FMA:9670)." [HPO:probinson]
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 HP:0005224 Rectal abscess 
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 HP:0005420 Recurrent staphylococcal and gram-negative infections 
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 HP:0007499 Recurrent staphylococcal infections 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000140678 ITGAX / P20702 / integrin subunit alpha X  / complex
 ENSG00000170458 CD14 / P08571 / CD14 molecule  / reaction / complex
 ENSG00000160255 ITGB2 / P05107 / integrin subunit beta 2  / reaction
 ENSG00000171557 FGG / P02679 / fibrinogen gamma chain  / complex / reaction
 ENSG00000171560 FGA / P02671 / fibrinogen alpha chain  / complex / reaction
 ENSG00000171564 FGB / P02675 / fibrinogen beta chain  / reaction / complex
 ENSG00000166086 JAM3 / Q9BX67 / junctional adhesion molecule 3  / reaction / complex
 ENSG00000169896 ITGAM / P11215 / integrin subunit alpha M  / complex / reaction
 ENSG00000158769 F11R / Q9Y624 / F11 receptor  / complex / reaction
 ENSG00000005844 ITGAL / P20701 / integrin subunit alpha L  / complex
 ENSG00000156886 ITGAD / Q13349 / integrin subunit alpha D  / complex






 

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