ENSG00000005844


Homo sapiens

Features
Gene ID: ENSG00000005844
  
Biological name :ITGAL
  
Synonyms : integrin subunit alpha L / ITGAL / P20701
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: p11.2
Gene start: 30472658
Gene end: 30523185
  
Corresponding Affymetrix probe sets: 1554240_a_at (Human Genome U133 Plus 2.0 Array)   213475_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000457785
Ensembl peptide - ENSP00000456888
Ensembl peptide - ENSP00000458739
Ensembl peptide - ENSP00000461006
Ensembl peptide - ENSP00000349252
Ensembl peptide - ENSP00000350886
Ensembl peptide - ENSP00000409377
Ensembl peptide - ENSP00000454342
Ensembl peptide - ENSP00000454908
Ensembl peptide - ENSP00000456521
NCBI entrez gene - 3683     See in Manteia.
OMIM - 153370
RefSeq - XM_011545849
RefSeq - NM_001114380
RefSeq - NM_002209
RefSeq - XM_005255313
RefSeq - XM_006721044
RefSeq Peptide - NP_001107852
RefSeq Peptide - NP_002200
swissprot - I3L468
swissprot - P20701
swissprot - B4DQ77
swissprot - B4E021
swissprot - H3BNL5
swissprot - H3BS37
swissprot - H3BUT3
swissprot - H3BSV1
swissprot - I3L1D1
Ensembl - ENSG00000005844
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zmp:0000001082ENSDARG00000098899Danio rerio
 ItgalENSMUSG00000030830Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ITGAX / P20702 / integrin subunit alpha XENSG0000014067832
ITGAM / P11215 / integrin subunit alpha MENSG0000016989632
ITGAD / Q13349 / integrin subunit alpha DENSG0000015688631
ITGA11 / Q9UKX5 / integrin subunit alpha 11ENSG0000013780927
ITGA10 / O75578 / integrin subunit alpha 10ENSG0000014312727
ITGA1 / P56199 / integrin subunit alpha 1ENSG0000021394926
ITGAE / P38570 / integrin subunit alpha EENSG0000008345725
ITGA2 / P17301 / integrin subunit alpha 2ENSG0000016417124
ITGA7 / Q13683 / integrin subunit alpha 7ENSG0000013542419
ITGA5 / P08648 / integrin subunit alpha 5ENSG0000016163819
ITGA3 / P26006 / integrin subunit alpha 3ENSG0000000588419
ITGA9 / Q13797 / integrin subunit alpha 9ENSG0000014466819
ITGA8 / P53708 / integrin subunit alpha 8ENSG0000007794319
ITGA4 / P13612 / integrin subunit alpha 4ENSG0000011523219
ITGAV / P06756 / integrin subunit alpha VENSG0000013844818
ITGA2B / P08514 / integrin subunit alpha 2bENSG0000000596117
ITGA6 / P23229 / integrin subunit alpha 6ENSG0000009140917


Protein motifs (from Interpro)
Interpro ID Name
 IPR000413  Integrin alpha chain
 IPR002035  von Willebrand factor, type A
 IPR013517  FG-GAP repeat
 IPR013519  Integrin alpha beta-propellor
 IPR013649  Integrin alpha-2
 IPR018184  Integrin alpha chain, C-terminal cytoplasmic region, conserved site
 IPR032695  Integrin domain superfamily
 IPR036465  von Willebrand factor A-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IMP
 biological_processGO:0006909 phagocytosis IEA
 biological_processGO:0006954 inflammatory response NAS
 biological_processGO:0007155 cell adhesion NAS
 biological_processGO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IMP
 biological_processGO:0007159 leukocyte cell-cell adhesion IMP
 biological_processGO:0007160 cell-matrix adhesion IMP
 biological_processGO:0007165 signal transduction NAS
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0030198 extracellular matrix organization TAS
 biological_processGO:0043113 receptor clustering IMP
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0050776 regulation of immune response TAS
 biological_processGO:0050900 leukocyte migration TAS
 biological_processGO:0098609 cell-cell adhesion IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0008305 integrin complex NAS
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0034687 integrin alphaL-beta2 complex IDA
 cellular_componentGO:0035579 specific granule membrane TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030369 ICAM-3 receptor activity IMP
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0050839 cell adhesion molecule binding IPI


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Cell surface interactions at the vascular wall
Integrin cell surface interactions
Neutrophil degranulation
RUNX3 Regulates Immune Response and Cell Migration


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000158769 F11R / Q9Y624 / F11 receptor  / reaction / complex
 ENSG00000160255 ITGB2 / P05107 / integrin subunit beta 2  / complex






 

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contact: otassy@igbmc.fr