ENSG00000161638


Homo sapiens

Features
Gene ID: ENSG00000161638
  
Biological name :ITGA5
  
Synonyms : integrin subunit alpha 5 / ITGA5 / P08648
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q13.13
Gene start: 54395261
Gene end: 54419460
  
Corresponding Affymetrix probe sets: 201389_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000447347
Ensembl peptide - ENSP00000450267
Ensembl peptide - ENSP00000293379
Ensembl peptide - ENSP00000405865
NCBI entrez gene - 3678     See in Manteia.
OMIM - 135620
RefSeq - NM_002205
RefSeq Peptide - NP_002196
swissprot - B4E3F4
swissprot - H0YHL9
swissprot - H0YIV7
swissprot - P08648
Ensembl - ENSG00000161638
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itga5ENSDARG00000006353Danio rerio
 Itga5ENSMUSG00000000555Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ITGAV / P06756 / integrin subunit alpha VENSG0000013844845
ITGA8 / P53708 / integrin subunit alpha 8ENSG0000007794345
ITGA2B / P08514 / integrin subunit alpha 2bENSG0000000596137
ITGA7 / Q13683 / integrin subunit alpha 7ENSG0000013542428
ITGA6 / P23229 / integrin subunit alpha 6ENSG0000009140927
ITGA9 / Q13797 / integrin subunit alpha 9ENSG0000014466825
ITGA3 / P26006 / integrin subunit alpha 3ENSG0000000588425
ITGA4 / P13612 / integrin subunit alpha 4ENSG0000011523225
ITGAX / P20702 / integrin subunit alpha XENSG0000014067823
ITGAM / P11215 / integrin subunit alpha MENSG0000016989622
ITGA1 / P56199 / integrin subunit alpha 1ENSG0000021394922
ITGA10 / O75578 / integrin subunit alpha 10ENSG0000014312722
ITGAD / Q13349 / integrin subunit alpha DENSG0000015688622
ITGA2 / P17301 / integrin subunit alpha 2ENSG0000016417121
ITGA11 / Q9UKX5 / integrin subunit alpha 11ENSG0000013780921
ITGAL / P20701 / integrin subunit alpha LENSG0000000584421
ITGAE / P38570 / integrin subunit alpha EENSG0000008345719


Protein motifs (from Interpro)
Interpro ID Name
 IPR000413  Integrin alpha chain
 IPR013517  FG-GAP repeat
 IPR013519  Integrin alpha beta-propellor
 IPR013649  Integrin alpha-2
 IPR018184  Integrin alpha chain, C-terminal cytoplasmic region, conserved site
 IPR032695  Integrin domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis TAS
 biological_processGO:0007044 cell-substrate junction assembly IEA
 biological_processGO:0007155 cell adhesion TAS
 biological_processGO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IEA
 biological_processGO:0007159 leukocyte cell-cell adhesion IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0007613 memory IEA
 biological_processGO:0010811 positive regulation of cell-substrate adhesion IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0030198 extracellular matrix organization TAS
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway TAS
 biological_processGO:0031589 cell-substrate adhesion IMP
 biological_processGO:0033627 cell adhesion mediated by integrin IDA
 biological_processGO:0033631 cell-cell adhesion mediated by integrin IEA
 biological_processGO:0034113 heterotypic cell-cell adhesion IMP
 biological_processGO:0035313 wound healing, spreading of epidermal cells IEP
 biological_processGO:0035987 endodermal cell differentiation IMP
 biological_processGO:0045765 regulation of angiogenesis IEA
 biological_processGO:0046718 viral entry into host cell IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IMP
 biological_processGO:0050900 leukocyte migration TAS
 biological_processGO:1903672 positive regulation of sprouting angiogenesis IMP
 biological_processGO:2000811 negative regulation of anoikis IMP
 cellular_componentGO:0001726 ruffle TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0008305 integrin complex TAS
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0032587 ruffle membrane IDA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0071062 alphav-beta3 integrin-vitronectin complex TAS
 molecular_functionGO:0001618 virus receptor activity IEA
 molecular_functionGO:0005154 epidermal growth factor receptor binding IEA
 molecular_functionGO:0005161 platelet-derived growth factor receptor binding TAS
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043184 vascular endothelial growth factor receptor 2 binding TAS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050839 cell adhesion molecule binding IEA


Pathways (from Reactome)
Pathway description
Elastic fibre formation
Fibronectin matrix formation
Cell surface interactions at the vascular wall
Integrin cell surface interactions
Signal transduction by L1
RUNX2 regulates genes involved in cell migration


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000105664 COMP / P49747 / cartilage oligomeric matrix protein  / complex / reaction
 ENSG00000118785 SPP1 / P10451 / secreted phosphoprotein 1  / reaction / complex
 ENSG00000115414 FN1 / P02751 / fibronectin 1  / complex / reaction
 ENSG00000150093 ITGB1 / P05556 / integrin subunit beta 1  / complex
 ENSG00000166147 FBN1 / P35555 / fibrillin 1  / complex / reaction






 

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