ENSDARG00000006353


Danio rerio

Features
Gene ID: ENSDARG00000006353
  
Biological name :itga5
  
Synonyms : integrin, alpha 5 (fibronectin receptor, alpha polypeptide) / itga5
  
Possible biological names infered from orthology : Integrin alpha-5 Integrin alpha-5 heavy chain Integrin alpha-5 light chain / integrin subunit alpha 5 / P08648 / P11688
  
Species: Danio rerio
  
Chr. number: 23
Strand: -1
Band:
Gene start: 33447625
Gene end: 33558161
  
Corresponding Affymetrix probe sets: Dr.22498.1.A1_at (Zebrafish Array)   NM_001004288_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000027718
NCBI entrez gene - 386787     See in Manteia.
RefSeq - NM_001004288
RefSeq Peptide - NP_001004288
swissprot - Q5I2A9
ZFIN ID - ZDB-GENE-031116-52
Ensembl - ENSDARG00000006353
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ITGA5ENSG00000161638Homo sapiens
 Itga5ENSMUSG00000000555Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
itga8 / integrin, alpha 8 / P53708* / A2ARA8* / integrin subunit alpha 8* / Integrin alpha-8 Integrin alpha-8 heavy chain Integrin alpha-8 light chain*ENSDARG0000007871747
itgav / integrin, alpha V / P06756* / integrin subunit alpha V*ENSDARG0000000631445
itga2b / integrin, alpha 2b / P08514* / Q9QUM0* / integrin subunit alpha 2b*ENSDARG0000001868737
itga6a / integrin, alpha 6a / ITGA6* / P23229* / Q61739* / integrin subunit alpha 6* / Integrin alpha-6 Integrin alpha-6 heavy chain Integrin alpha-6 light chain*ENSDARG0000004228225
itga3b / integrin, alpha 3b / ITGA3* / P26006* / Q62470* / integrin subunit alpha 3* / Integrin alpha-3 Integrin alpha-3 heavy chain Integrin alpha-3 light chain*ENSDARG0000001282425
itga6b / integrin, alpha 6b / ITGA6* / P23229* / Q61739* / integrin subunit alpha 6* / Integrin alpha-6 Integrin alpha-6 heavy chain Integrin alpha-6 light chain*ENSDARG0000006994624
itga9 / integrin, alpha 9 / Q13797* / integrin subunit alpha 9*ENSDARG0000003243524
itga10 / integrin, alpha 10 / O75578* / integrin subunit alpha 10*ENSDARG0000000250723
itga6l / integrin, alpha 6, like / ITGA6* / P23229* / Q61739* / integrin subunit alpha 6* / Integrin alpha-6 Integrin alpha-6 heavy chain Integrin alpha-6 light chain*ENSDARG0000005601823
itga4 / integrin alpha 4 / P13612* / integrin subunit alpha 4*ENSDARG0000010305623
itga3a / integrin, alpha 3a / ITGA3* / P26006* / Q62470* / integrin subunit alpha 3* / Integrin alpha-3 Integrin alpha-3 heavy chain Integrin alpha-3 light chain*ENSDARG0000003791723
itga11a / integrin, alpha 11a / ITGA11* / Q9UKX5* / integrin subunit alpha 11*ENSDARG0000003608622
itga1 / integrin, alpha 1 / P56199* / Q3V3R4* / integrin subunit alpha 1*ENSDARG0000007431621
itga2.2 / integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor), tandem duplicate 2 / ITGA2* / P17301* / Q62469* / Integrin alpha-2 * / integrin subunit alpha 2*ENSDARG0000006297421
itga11b / integrin, alpha 11b / ITGA11* / Q9UKX5* / integrin subunit alpha 11*ENSDARG0000000795020
si:dkey-32n7.4 / ITGAD* / ITGAM* / ITGAX* / Q13349* / P11215* / P20702* / Q9QXH4* / Q3V0T4* / integrin alpha M* / Integrin alpha-X * / Integrin alpha-D * / integrin subunit alpha X* / integ...ENSDARG0000000295619
zmp:0000001082 / ITGAL* / P20701* / P24063* / Integrin alpha-L * / integrin subunit alpha L*ENSDARG0000009889917
itgae.2 / integrin, alpha E, tandem duplicate 2 / ITGAE* / P38570* / Q60677* / integrin subunit alpha E* / integrin alpha E, epithelial-associated*ENSDARG0000005778715
itgam / integrin, alpha M (complement component 3 receptor 3 subunit) / ITGAD* / ITGAX* / P11215* / P20702* / Q13349* / Q3V0T4* / Q9QXH4* / integrin alpha M* / Integrin alpha-X * / Integrin...ENSDARG0000009658714
CU469503.1 / ITGA6* / P23229* / Q61739* / integrin subunit alpha 6* / Integrin alpha-6 Integrin alpha-6 heavy chain Integrin alpha-6 light chain*ENSDARG0000009934810


Protein motifs (from Interpro)
Interpro ID Name
 IPR000413  Integrin alpha chain
 IPR013517  FG-GAP repeat
 IPR013519  Integrin alpha beta-propellor
 IPR013649  Integrin alpha-2
 IPR018184  Integrin alpha chain, C-terminal cytoplasmic region, conserved site
 IPR032695  Integrin domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IMP
 biological_processGO:0001756 somitogenesis IMP
 biological_processGO:0001944 vasculature development IMP
 biological_processGO:0002042 cell migration involved in sprouting angiogenesis IMP
 biological_processGO:0002089 lens morphogenesis in camera-type eye IMP
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0030325 adrenal gland development IMP
 biological_processGO:0032525 somite rostral/caudal axis specification IGI
 biological_processGO:0048703 embryonic viscerocranium morphogenesis IMP
 biological_processGO:0070309 lens fiber cell morphogenesis IMP
 biological_processGO:0085029 extracellular matrix assembly IMP
 biological_processGO:0090245 axis elongation involved in somitogenesis IMP
 cellular_componentGO:0008305 integrin complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane NAS
 molecular_functionGO:0001968 fibronectin binding IGI
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
Elastic fibre formation
Fibronectin matrix formation
Cell surface interactions at the vascular wall
Integrin cell surface interactions
Signal transduction by L1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000035 lens lens morphology , abnormal
lens nucleus increased amount , abnormal
lens separated from retina , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0000155 somite somite shape , abnormal
somite quality , abnormal
somite degenerate , abnormal
Show

 ZFA:0000692 symplectic symplectic quality , abnormal
Show

 ZFA:0001058 caudal fin caudal fin morphology , abnormal
Show

 ZFA:0001115 trunk trunk interstitial matrix morphology , abnormal
Show

 ZFA:0001216 splanchnocranium splanchnocranium quality , abnormal
Show

 ZFA:0001276 pharyngeal arch 2 skeleton pharyngeal arch 2 skeleton quality , abnormal
Show

 ZFA:0001285 intersegmental vessel intersegmental vessel decreased length , abnormal
intersegmental vessel vasculature development delayed , abnormal
Show

 ZFA:0001346 interrenal primordium interrenal primordium morphology , abnormal
interrenal primordium position , abnormal
interrenal primordium left side unfused from interrenal primordium right side, abnormal
Show

 ZFA:0001460 pharyngeal arch cartilage pharyngeal arch cartilage has fewer parts of type ceratobranchial cartilage , abnormal
pharyngeal arch cartilage lacks all parts of type ceratobranchial 2 cartilage , abnormal
pharyngeal arch cartilage lacks all parts of type ceratobranchial 3 cartilage , abnormal
pharyngeal arch cartilage lacks all parts of type ceratobranchial 4 cartilage , abnormal
pharyngeal arch cartilage lacks all parts of type ceratobranchial 5 cartilage , abnormal
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 ZFA:0001462 somite border somite border aplastic/hypoplastic , abnormal
somite border malformed , abnormal
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 ZFA:0001520 ceratobranchial 1 cartilage ceratobranchial 1 cartilage fused with ceratobranchial 2 cartilage , abnormal
Show

 ZFA:0005802 interrenal angiogenic sprout interrenal angiogenic sprout absent , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000019815 fn1a / fibronectin 1a / FN1* / P02751* / P11276* / fibronectin 1* / Fibronectin Anastellin*  / complex / reaction
 ENSDARG00000098431 COMP / si:ch211-43f4.1 / P49747* / Q9R0G6* / cartilage oligomeric matrix protein*  / reaction / complex
 ENSDARG00000006526 fn1b / fibronectin 1b / FN1* / P02751* / P11276* / fibronectin 1* / Fibronectin Anastellin*  / reaction / complex
 ENSDARG00000071863 itgb1a / integrin, beta 1a / ITGB1* / P05556* / P09055* / Integrin beta-1 * / integrin subunit beta 1*  / complex






 

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