ENSDARG00000018687


Danio rerio

Features
Gene ID: ENSDARG00000018687
  
Biological name :itga2b
  
Synonyms : integrin, alpha 2b / itga2b
  
Possible biological names infered from orthology : integrin subunit alpha 2b / P08514 / Q9QUM0
  
Species: Danio rerio
  
Chr. number: 3
Strand: -1
Band:
Gene start: 21350509
Gene end: 21382491
  
Corresponding Affymetrix probe sets: DrAffx.1.8.S1_at (Zebrafish Array)   NM_001003857_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000013339
NCBI entrez gene - 445380     See in Manteia.
RefSeq - NM_001003857
RefSeq Peptide - NP_001003857
swissprot - B3DIZ6
ZFIN ID - ZDB-GENE-051031-1
Ensembl - ENSDARG00000018687
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ITGA2BENSG00000005961Homo sapiens
 Itga2bENSMUSG00000034664Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
itga8 / integrin, alpha 8 / P53708* / A2ARA8* / integrin subunit alpha 8* / Integrin alpha-8 Integrin alpha-8 heavy chain Integrin alpha-8 light chain*ENSDARG0000007871740
itgav / integrin, alpha V / P06756* / integrin subunit alpha V*ENSDARG0000000631438
itga5 / integrin, alpha 5 (fibronectin receptor, alpha polypeptide) / P08648* / P11688* / integrin subunit alpha 5* / Integrin alpha-5 Integrin alpha-5 heavy chain Integrin alpha-5 light chain*ENSDARG0000000635338
itga3b / integrin, alpha 3b / ITGA3* / P26006* / Q62470* / integrin subunit alpha 3* / Integrin alpha-3 Integrin alpha-3 heavy chain Integrin alpha-3 light chain*ENSDARG0000001282424
itga9 / integrin, alpha 9 / Q13797* / integrin subunit alpha 9*ENSDARG0000003243523
itga6b / integrin, alpha 6b / ITGA6* / P23229* / Q61739* / integrin subunit alpha 6* / Integrin alpha-6 Integrin alpha-6 heavy chain Integrin alpha-6 light chain*ENSDARG0000006994623
itga6a / integrin, alpha 6a / ITGA6* / P23229* / Q61739* / integrin subunit alpha 6* / Integrin alpha-6 Integrin alpha-6 heavy chain Integrin alpha-6 light chain*ENSDARG0000004228223
itga6l / integrin, alpha 6, like / ITGA6* / P23229* / Q61739* / integrin subunit alpha 6* / Integrin alpha-6 Integrin alpha-6 heavy chain Integrin alpha-6 light chain*ENSDARG0000005601822
itga10 / integrin, alpha 10 / O75578* / integrin subunit alpha 10*ENSDARG0000000250722
itga4 / integrin alpha 4 / P13612* / integrin subunit alpha 4*ENSDARG0000010305622
itga11a / integrin, alpha 11a / ITGA11* / Q9UKX5* / integrin subunit alpha 11*ENSDARG0000003608621
itga2.2 / integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor), tandem duplicate 2 / ITGA2* / P17301* / Q62469* / Integrin alpha-2 * / integrin subunit alpha 2*ENSDARG0000006297421
itga1 / integrin, alpha 1 / P56199* / Q3V3R4* / integrin subunit alpha 1*ENSDARG0000007431620
itga3a / integrin, alpha 3a / ITGA3* / P26006* / Q62470* / integrin subunit alpha 3* / Integrin alpha-3 Integrin alpha-3 heavy chain Integrin alpha-3 light chain*ENSDARG0000003791720
itga11b / integrin, alpha 11b / ITGA11* / Q9UKX5* / integrin subunit alpha 11*ENSDARG0000000795020
zmp:0000001082 / ITGAL* / P20701* / P24063* / Integrin alpha-L * / integrin subunit alpha L*ENSDARG0000009889918
si:dkey-32n7.4 / ITGAD* / ITGAM* / ITGAX* / Q13349* / P11215* / P20702* / Q9QXH4* / Q3V0T4* / integrin alpha M* / Integrin alpha-X * / Integrin alpha-D * / integrin subunit alpha X* / integ...ENSDARG0000000295618
itgae.2 / integrin, alpha E, tandem duplicate 2 / ITGAE* / P38570* / Q60677* / integrin subunit alpha E* / integrin alpha E, epithelial-associated*ENSDARG0000005778715
itgam / integrin, alpha M (complement component 3 receptor 3 subunit) / ITGAD* / ITGAX* / P11215* / P20702* / Q13349* / Q3V0T4* / Q9QXH4* / integrin alpha M* / Integrin alpha-X * / Integrin...ENSDARG0000009658713
CU469503.1 / ITGA6* / P23229* / Q61739* / integrin subunit alpha 6* / Integrin alpha-6 Integrin alpha-6 heavy chain Integrin alpha-6 light chain*ENSDARG000000993489


Protein motifs (from Interpro)
Interpro ID Name
 IPR000413  Integrin alpha chain
 IPR013517  FG-GAP repeat
 IPR013519  Integrin alpha beta-propellor
 IPR013649  Integrin alpha-2
 IPR018184  Integrin alpha chain, C-terminal cytoplasmic region, conserved site
 IPR032695  Integrin domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0001935 endothelial cell proliferation IMP
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0007596 blood coagulation IMP
 cellular_componentGO:0008305 integrin complex IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Platelet degranulation
Integrin cell surface interactions
ECM proteoglycans
Integrin alphaIIb beta3 signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
Signal transduction by L1
MAP2K and MAPK activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000011 caudal artery caudal artery decreased accumulation thrombocyte , abnormal
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 ZFA:0001057 intersegmental vein intersegmental vein physical quality , abnormal
Show

 ZFA:0001094 whole organism whole organism kinked , abnormal
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 ZFA:0001117 post-vent region post-vent region curled , abnormal
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 ZFA:0001286 caudal vein plexus caudal vein plexus morphology , abnormal
caudal vein plexus branchiness , abnormal
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 ZFA:0005035 subintestinal vein subintestinal vein aplastic , abnormal
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 ZFA:0009036 blood vessel endothelial cell blood vessel endothelial cell decreased amount , abnormal
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 ZFA:0009323 thrombocyte thrombocyte distributed , abnormal
thrombocyte decreased functionality , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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