ENSDARG00000006314


Danio rerio

Features
Gene ID: ENSDARG00000006314
  
Biological name :itgav
  
Synonyms : integrin, alpha V / itgav
  
Possible biological names infered from orthology : Integrin alpha-V Integrin alpha-V heavy chain Integrin alpha-V light chain / integrin subunit alpha V / P06756 / P43406
  
Species: Danio rerio
  
Chr. number: 9
Strand: -1
Band:
Gene start: 11597500
Gene end: 11655031
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000044313
NCBI entrez gene - 100151255     See in Manteia.
RefSeq - NM_001033721
RefSeq Peptide - NP_001028893
swissprot - B8JLK8
ZFIN ID - ZDB-GENE-060616-382
Ensembl - ENSDARG00000006314
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ITGAVENSGALG00000002655Gallus gallus
 ITGAVENSG00000138448Homo sapiens
 ItgavENSMUSG00000027087Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
itga5 / integrin, alpha 5 (fibronectin receptor, alpha polypeptide) / P08648* / P11688* / integrin subunit alpha 5* / Integrin alpha-5 Integrin alpha-5 heavy chain Integrin alpha-5 light chain*ENSDARG0000000635346
itga8 / integrin, alpha 8 / P53708* / A2ARA8* / integrin subunit alpha 8* / Integrin alpha-8 Integrin alpha-8 heavy chain Integrin alpha-8 light chain*ENSDARG0000007871746
itga2b / integrin, alpha 2b / P08514* / Q9QUM0* / integrin subunit alpha 2b*ENSDARG0000001868738
itga6a / integrin, alpha 6a / ITGA6* / P23229* / Q61739* / integrin subunit alpha 6* / Integrin alpha-6 Integrin alpha-6 heavy chain Integrin alpha-6 light chain*ENSDARG0000004228227
itga6b / integrin, alpha 6b / ITGA6* / P23229* / Q61739* / integrin subunit alpha 6* / Integrin alpha-6 Integrin alpha-6 heavy chain Integrin alpha-6 light chain*ENSDARG0000006994626
itga3a / integrin, alpha 3a / ITGA3* / P26006* / Q62470* / integrin subunit alpha 3* / Integrin alpha-3 Integrin alpha-3 heavy chain Integrin alpha-3 light chain*ENSDARG0000003791725
itga9 / integrin, alpha 9 / Q13797* / integrin subunit alpha 9*ENSDARG0000003243524
itga4 / integrin alpha 4 / P13612* / integrin subunit alpha 4*ENSDARG0000010305624
itga6l / integrin, alpha 6, like / ITGA6* / P23229* / Q61739* / integrin subunit alpha 6* / Integrin alpha-6 Integrin alpha-6 heavy chain Integrin alpha-6 light chain*ENSDARG0000005601824
itga3b / integrin, alpha 3b / ITGA3* / P26006* / Q62470* / integrin subunit alpha 3* / Integrin alpha-3 Integrin alpha-3 heavy chain Integrin alpha-3 light chain*ENSDARG0000001282424
itga10 / integrin, alpha 10 / O75578* / integrin subunit alpha 10*ENSDARG0000000250722
itga11a / integrin, alpha 11a / ITGA11* / Q9UKX5* / integrin subunit alpha 11*ENSDARG0000003608622
itga2.2 / integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor), tandem duplicate 2 / ITGA2* / P17301* / Q62469* / Integrin alpha-2 * / integrin subunit alpha 2*ENSDARG0000006297421
itga1 / integrin, alpha 1 / P56199* / Q3V3R4* / integrin subunit alpha 1*ENSDARG0000007431621
itga11b / integrin, alpha 11b / ITGA11* / Q9UKX5* / integrin subunit alpha 11*ENSDARG0000000795020
si:dkey-32n7.4 / ITGAD* / ITGAM* / ITGAX* / Q13349* / P11215* / P20702* / Q9QXH4* / Q3V0T4* / integrin alpha M* / Integrin alpha-X * / Integrin alpha-D * / integrin subunit alpha X* / integ...ENSDARG0000000295618
zmp:0000001082 / ITGAL* / P20701* / P24063* / Integrin alpha-L * / integrin subunit alpha L*ENSDARG0000009889917
itgae.2 / integrin, alpha E, tandem duplicate 2 / ITGAE* / P38570* / Q60677* / integrin subunit alpha E* / integrin alpha E, epithelial-associated*ENSDARG0000005778715
itgam / integrin, alpha M (complement component 3 receptor 3 subunit) / ITGAD* / ITGAX* / P11215* / P20702* / Q13349* / Q3V0T4* / Q9QXH4* / integrin alpha M* / Integrin alpha-X * / Integrin...ENSDARG0000009658714
CU469503.1 / ITGA6* / P23229* / Q61739* / integrin subunit alpha 6* / Integrin alpha-6 Integrin alpha-6 heavy chain Integrin alpha-6 light chain*ENSDARG0000009934811


Protein motifs (from Interpro)
Interpro ID Name
 IPR000413  Integrin alpha chain
 IPR013517  FG-GAP repeat
 IPR013519  Integrin alpha beta-propellor
 IPR013649  Integrin alpha-2
 IPR018184  Integrin alpha chain, C-terminal cytoplasmic region, conserved site
 IPR032695  Integrin domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IGI
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0001935 endothelial cell proliferation IGI
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0016477 cell migration IGI
 biological_processGO:0042074 cell migration involved in gastrulation IMP
 biological_processGO:0070121 Kupffer"s vesicle development IMP
 biological_processGO:0090245 axis elongation involved in somitogenesis IMP
 cellular_componentGO:0008305 integrin complex IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Cross-presentation of particulate exogenous antigens (phagosomes)
Elastic fibre formation
Molecules associated with elastic fibres
Integrin cell surface interactions
ECM proteoglycans
VEGFA-VEGFR2 Pathway
Signal transduction by L1
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000001 Kupffer s vesicle Kupffers vesicle decreased volume , abnormal
Kupffers vesicle cilium decreased amount , abnormal
Kupffers vesicle unlumenized , abnormal
Kupffers vesicle epithelial cell apical-basal polarity , abnormal
Show

 ZFA:0000008 brain brain hemorrhagic , abnormal
brain hydrocephalic , abnormal
Show

 ZFA:0000023 forerunner cell group forerunner cell group spatial pattern , abnormal
forerunner cell group stratification , abnormal
forerunner cell group disorganized , abnormal
forerunner cell group orientation forerunner cell group , abnormal
forerunner cell group circular , abnormal
forerunner cell group detached from forerunner cell group , abnormal
forerunner cell group pseudopodium direction , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000099 brain vasculature brain vasculature broken , abnormal
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 ZFA:0000100 cerebellum cerebellum malformed , abnormal
Show

 ZFA:0000110 fourth ventricle fourth ventricle increased accumulation cerebral spinal fluid , abnormal
Show

 ZFA:0000155 somite somite absent , abnormal
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 ZFA:0000180 caudal vein caudal vein ventral region decreased diameter , abnormal
Show

 ZFA:0000360 heart tube heart tube positional polarity , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased length , abnormal
Show

 ZFA:0001286 caudal vein plexus caudal vein plexus ventral region decreased diameter , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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