ENSGALG00000002655


Gallus gallus

Features
Gene ID: ENSGALG00000002655
  
Biological name :ITGAV
  
Synonyms : integrin alpha-V precursor / ITGAV
  
Possible biological names infered from orthology : Integrin alpha-V Integrin alpha-V heavy chain Integrin alpha-V light chain / integrin subunit alpha V / P06756 / P43406
  
Species: Gallus gallus
  
Chr. number: 7
Strand: -1
Band:
Gene start: 1319204
Gene end: 1364895
  
Corresponding Affymetrix probe sets: Gga.815.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000047574
Ensembl peptide - ENSGALP00000004173
NCBI entrez gene - 396420     See in Manteia.
RefSeq - NM_205439
RefSeq Peptide - NP_990770
swissprot - F1NGX1
swissprot - A0A1D5P4G6
Ensembl - ENSGALG00000002655
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itgavENSDARG00000006314Danio rerio
 ITGAVENSG00000138448Homo sapiens
 ItgavENSMUSG00000027087Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ITGA8 / integrin alpha-8 precursor / A2ARA8* / P53708* / integrin subunit alpha 8* / Integrin alpha-8 Integrin alpha-8 heavy chain Integrin alpha-8 light chain*ENSGALG0000000874747
ITGA3 / integrin alpha-3 precursor / P26006* / Q62470* / integrin subunit alpha 3* / Integrin alpha-3 Integrin alpha-3 heavy chain Integrin alpha-3 light chain*ENSGALG0000003270226
ITGA6 / integrin alpha-6 precursor / P23229* / Q61739* / integrin subunit alpha 6* / Integrin alpha-6 Integrin alpha-6 heavy chain Integrin alpha-6 light chain*ENSGALG0000003400726
ITGA4 / integrin subunit alpha 4 / P13612*ENSGALG0000004157724
ITGA9 / integrin alpha-9 precursor / B8JK39* / Q13797* / Integrin alpha-9 * / integrin subunit alpha 9*ENSGALG0000002937824
ITGA2 / integrin subunit alpha 2 / P17301* / Q62469* / Integrin alpha-2 *ENSGALG0000001490323
ITGA11 / integrin subunit alpha 11 / Q9UKX5*ENSGALG0000000800722
ITGA1 / integrin alpha-1 precursor / Q3V3R4* / P56199* / Integrin alpha-1 * / integrin subunit alpha 1*ENSGALG0000001489121
ITGAD* / ITGAM* / ITGAX* / P11215* / P20702* / Q13349* / Q3V0T4* / Q9QXH4* / integrin alpha M* / Integrin alpha-X * / Integrin alpha-D * / integrin subunit alpha X* / integrin subunit alpha...ENSGALG0000004129818


Protein motifs (from Interpro)
Interpro ID Name
 IPR000413  Integrin alpha chain
 IPR013517  FG-GAP repeat
 IPR013519  Integrin alpha beta-propellor
 IPR013649  Integrin alpha-2
 IPR018184  Integrin alpha chain, C-terminal cytoplasmic region, conserved site
 IPR032695  Integrin domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001568 blood vessel development IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007160 cell-matrix adhesion IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010745 negative regulation of macrophage derived foam cell differentiation IEA
 biological_processGO:0010888 negative regulation of lipid storage IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0031589 cell-substrate adhesion IEA
 biological_processGO:0032369 negative regulation of lipid transport IEA
 biological_processGO:0033627 cell adhesion mediated by integrin IEA
 biological_processGO:0033690 positive regulation of osteoblast proliferation IEA
 biological_processGO:0034113 heterotypic cell-cell adhesion IEA
 biological_processGO:0034446 substrate adhesion-dependent cell spreading IEA
 biological_processGO:0035987 endodermal cell differentiation IEA
 biological_processGO:0038027 apolipoprotein A-I-mediated signaling pathway IEA
 biological_processGO:0038044 transforming growth factor-beta secretion IEA
 biological_processGO:0043277 apoptotic cell clearance IEA
 biological_processGO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process IEA
 biological_processGO:0045785 positive regulation of cell adhesion IEA
 biological_processGO:0046718 viral entry into host cell IEA
 biological_processGO:0050748 negative regulation of lipoprotein metabolic process IEA
 biological_processGO:0050764 regulation of phagocytosis IEA
 biological_processGO:0050919 negative chemotaxis IEA
 biological_processGO:0070371 ERK1 and ERK2 cascade IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IEA
 biological_processGO:2000536 negative regulation of entry of bacterium into host cell IEA
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0008305 integrin complex IEA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031258 lamellipodium membrane IEA
 cellular_componentGO:0031527 filopodium membrane IEA
 cellular_componentGO:0031528 microvillus membrane IEA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0034683 integrin alphav-beta3 complex IEA
 cellular_componentGO:0034684 integrin alphav-beta5 complex IEA
 cellular_componentGO:0034685 integrin alphav-beta6 complex IEA
 cellular_componentGO:0034686 integrin alphav-beta8 complex IEA
 cellular_componentGO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex IEA
 cellular_componentGO:0035868 alphav-beta3 integrin-HMGB1 complex IEA
 molecular_functionGO:0001846 opsonin binding IEA
 molecular_functionGO:0001968 fibronectin binding IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0005080 protein kinase C binding IEA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0005245 voltage-gated calcium channel activity IEA
 molecular_functionGO:0017134 fibroblast growth factor binding IEA
 molecular_functionGO:0019960 C-X3-C chemokine binding IEA
 molecular_functionGO:0031994 insulin-like growth factor I binding IEA
 molecular_functionGO:0038132 neuregulin binding IEA
 molecular_functionGO:0050840 extracellular matrix binding IEA
 molecular_functionGO:1990430 extracellular matrix protein binding IEA


Pathways (from Reactome)
Pathway description
Cross-presentation of particulate exogenous antigens (phagosomes)
Elastic fibre formation
Molecules associated with elastic fibres
Integrin cell surface interactions
Syndecan interactions
ECM proteoglycans
VEGFA-VEGFR2 Pathway
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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