ENSGALG00000041577


Gallus gallus

Features
Gene ID: ENSGALG00000041577
  
Biological name :ITGA4
  
Synonyms : integrin subunit alpha 4 / ITGA4
  
Possible biological names infered from orthology : P13612
  
Species: Gallus gallus
  
Chr. number: 7
Strand: -1
Band:
Gene start: 14373277
Gene end: 14404802
  
Corresponding Affymetrix probe sets: Gga.4999.1.S1_a_at (Chicken Array)   Gga.4999.2.S1_at (Chicken Array)   GgaAffx.5654.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000053380
NCBI entrez gene - 424121     See in Manteia.
RefSeq - XM_421974
swissprot - A0A1D5PKL9
Ensembl - ENSGALG00000041577
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itga4ENSDARG00000103056Danio rerio
 ITGA4ENSG00000115232Homo sapiens
 Itga4ENSMUSG00000027009Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ITGA9 / integrin alpha-9 precursor / B8JK39* / Q13797* / Integrin alpha-9 * / integrin subunit alpha 9*ENSGALG0000002937841
ITGA6 / integrin alpha-6 precursor / P23229* / Q61739* / integrin subunit alpha 6* / Integrin alpha-6 Integrin alpha-6 heavy chain Integrin alpha-6 light chain*ENSGALG0000003400726
ITGA8 / integrin alpha-8 precursor / A2ARA8* / P53708* / integrin subunit alpha 8* / Integrin alpha-8 Integrin alpha-8 heavy chain Integrin alpha-8 light chain*ENSGALG0000000874724
ITGAV / integrin alpha-V precursor / P06756* / P43406* / integrin subunit alpha V* / Integrin alpha-V Integrin alpha-V heavy chain Integrin alpha-V light chain*ENSGALG0000000265524
ITGA11 / integrin subunit alpha 11 / Q9UKX5*ENSGALG0000000800723
ITGA3 / integrin alpha-3 precursor / P26006* / Q62470* / integrin subunit alpha 3* / Integrin alpha-3 Integrin alpha-3 heavy chain Integrin alpha-3 light chain*ENSGALG0000003270223
ITGA1 / integrin alpha-1 precursor / Q3V3R4* / P56199* / Integrin alpha-1 * / integrin subunit alpha 1*ENSGALG0000001489121
ITGA2 / integrin subunit alpha 2 / P17301* / Q62469* / Integrin alpha-2 *ENSGALG0000001490321
ITGAD* / ITGAM* / ITGAX* / P11215* / P20702* / Q13349* / Q3V0T4* / Q9QXH4* / integrin alpha M* / Integrin alpha-X * / Integrin alpha-D * / integrin subunit alpha X* / integrin subunit alpha...ENSGALG0000004129819


Protein motifs (from Interpro)
Interpro ID Name
 IPR000413  Integrin alpha chain
 IPR013517  FG-GAP repeat
 IPR013519  Integrin alpha beta-propellor
 IPR013649  Integrin alpha-2
 IPR018184  Integrin alpha chain, C-terminal cytoplasmic region, conserved site
 IPR032695  Integrin domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003366 cell-matrix adhesion involved in ameboidal cell migration IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007159 leukocyte cell-cell adhesion IEA
 biological_processGO:0007160 cell-matrix adhesion IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0034113 heterotypic cell-cell adhesion IEA
 biological_processGO:0034446 substrate adhesion-dependent cell spreading IEA
 biological_processGO:0035987 endodermal cell differentiation IEA
 biological_processGO:0043113 receptor clustering IEA
 biological_processGO:0050901 leukocyte tethering or rolling IEA
 biological_processGO:0090074 negative regulation of protein homodimerization activity IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0008305 integrin complex IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0034669 integrin alpha4-beta7 complex IEA
 molecular_functionGO:0019960 C-X3-C chemokine binding IEA
 molecular_functionGO:0050839 cell adhesion molecule binding IEA


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Cell surface interactions at the vascular wall
Integrin cell surface interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001472 JAM3 / junctional adhesion molecule 3 / Q9BX67* / Q9D8B7* / Junctional adhesion molecule C *  / complex / reaction
 ENSGALG00000007145 ITGB1 / integrin subunit beta 1 / P05556* / P09055* / Integrin beta-1 *  / complex
 ENSGALG00000005257 VCAM1 / vascular cell adhesion molecule 1 / P19320* / P29533*  / reaction / complex
 ENSGALG00000015746 JAM2 / junctional adhesion molecule 2 / P57087* / Q9JI59* / Junctional adhesion molecule B *  / complex / reaction






 

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