ENSG00000115232


Homo sapiens

Features
Gene ID: ENSG00000115232
  
Biological name :ITGA4
  
Synonyms : integrin subunit alpha 4 / ITGA4 / P13612
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q31.3
Gene start: 181457202
Gene end: 181536187
  
Corresponding Affymetrix probe sets: 205884_at (Human Genome U133 Plus 2.0 Array)   205885_s_at (Human Genome U133 Plus 2.0 Array)   213416_at (Human Genome U133 Plus 2.0 Array)   243685_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000340149
Ensembl peptide - ENSP00000380227
Ensembl peptide - ENSP00000233573
NCBI entrez gene - 3676     See in Manteia.
OMIM - 192975
RefSeq - NM_000885
RefSeq - NM_001316312
RefSeq Peptide - NP_000876
RefSeq Peptide - NP_001303241
swissprot - E7EP60
swissprot - P13612
Ensembl - ENSG00000115232
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itga4ENSDARG00000103056Danio rerio
 ITGA4ENSGALG00000041577Gallus gallus
 Itga4ENSMUSG00000027009Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ITGA9 / Q13797 / integrin subunit alpha 9ENSG0000014466842
ITGA2B / P08514 / integrin subunit alpha 2bENSG0000000596126
ITGA6 / P23229 / integrin subunit alpha 6ENSG0000009140926
ITGAV / P06756 / integrin subunit alpha VENSG0000013844826
ITGA5 / P08648 / integrin subunit alpha 5ENSG0000016163825
ITGA7 / Q13683 / integrin subunit alpha 7ENSG0000013542425
ITGA8 / P53708 / integrin subunit alpha 8ENSG0000007794325
ITGA3 / P26006 / integrin subunit alpha 3ENSG0000000588423
ITGAX / P20702 / integrin subunit alpha XENSG0000014067823
ITGA11 / Q9UKX5 / integrin subunit alpha 11ENSG0000013780923
ITGAD / Q13349 / integrin subunit alpha DENSG0000015688622
ITGA2 / P17301 / integrin subunit alpha 2ENSG0000016417122
ITGAM / P11215 / integrin subunit alpha MENSG0000016989622
ITGA1 / P56199 / integrin subunit alpha 1ENSG0000021394922
ITGA10 / O75578 / integrin subunit alpha 10ENSG0000014312721
ITGAL / P20701 / integrin subunit alpha LENSG0000000584421
ITGAE / P38570 / integrin subunit alpha EENSG0000008345720


Protein motifs (from Interpro)
Interpro ID Name
 IPR000413  Integrin alpha chain
 IPR013517  FG-GAP repeat
 IPR013519  Integrin alpha beta-propellor
 IPR013649  Integrin alpha-2
 IPR018184  Integrin alpha chain, C-terminal cytoplasmic region, conserved site
 IPR032695  Integrin domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002687 positive regulation of leukocyte migration IEA
 biological_processGO:0003366 cell-matrix adhesion involved in ameboidal cell migration IMP
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007159 leukocyte cell-cell adhesion IDA
 biological_processGO:0007160 cell-matrix adhesion IMP
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0030183 B cell differentiation IC
 biological_processGO:0030198 extracellular matrix organization TAS
 biological_processGO:0034113 heterotypic cell-cell adhesion IMP
 biological_processGO:0034446 substrate adhesion-dependent cell spreading IMP
 biological_processGO:0035987 endodermal cell differentiation IEP
 biological_processGO:0043113 receptor clustering IMP
 biological_processGO:0050776 regulation of immune response TAS
 biological_processGO:0050900 leukocyte migration TAS
 biological_processGO:0050901 leukocyte tethering or rolling IMP
 biological_processGO:0050904 diapedesis IEA
 biological_processGO:0071345 cellular response to cytokine stimulus IEA
 biological_processGO:0090074 negative regulation of protein homodimerization activity IDA
 biological_processGO:0098657 import into cell IEA
 biological_processGO:1903039 positive regulation of leukocyte cell-cell adhesion IEA
 biological_processGO:1903238 positive regulation of leukocyte tethering or rolling IEA
 biological_processGO:1990771 clathrin-dependent extracellular exosome endocytosis IEA
 biological_processGO:2000406 positive regulation of T cell migration IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0008305 integrin complex IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0034669 integrin alpha4-beta7 complex IDA
 cellular_componentGO:0070062 extracellular exosome IEA
 molecular_functionGO:0001968 fibronectin binding IEA
 molecular_functionGO:0003823 antigen binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015026 coreceptor activity TAS
 molecular_functionGO:0019960 C-X3-C chemokine binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050839 cell adhesion molecule binding IEA
 molecular_functionGO:1990405 protein antigen binding IEA


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Cell surface interactions at the vascular wall
Integrin cell surface interactions
RUNX3 Regulates Immune Response and Cell Migration


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000099866 Q13477 / MADCAM1 / mucosal vascular addressin cell adhesion molecule 1  / reaction / complex
 ENSG00000150093 ITGB1 / P05556 / integrin subunit beta 1  / complex
 ENSG00000139626 ITGB7 / P26010 / integrin subunit beta 7  / complex
 ENSG00000118785 SPP1 / P10451 / secreted phosphoprotein 1  / complex / reaction
 ENSG00000137801 THBS1 / P07996 / thrombospondin 1  / complex / reaction
 ENSG00000162692 VCAM1 / P19320 / vascular cell adhesion molecule 1  / reaction / complex
 ENSG00000154721 JAM2 / P57087 / junctional adhesion molecule 2  / reaction / complex
 ENSG00000166086 JAM3 / Q9BX67 / junctional adhesion molecule 3  / reaction / complex






 

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