ENSG00000162692


Homo sapiens

Features
Gene ID: ENSG00000162692
  
Biological name :VCAM1
  
Synonyms : P19320 / vascular cell adhesion molecule 1 / VCAM1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p21.2
Gene start: 100719742
Gene end: 100739045
  
Corresponding Affymetrix probe sets: 203868_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000359137
Ensembl peptide - ENSP00000294728
Ensembl peptide - ENSP00000304611
Ensembl peptide - ENSP00000359133
NCBI entrez gene - 7412     See in Manteia.
OMIM - 192225
RefSeq - NM_001078
RefSeq - NM_001199834
RefSeq - NM_080682
RefSeq Peptide - NP_001069
RefSeq Peptide - NP_001186763
RefSeq Peptide - NP_542413
swissprot - P19320
swissprot - E9PDD2
Ensembl - ENSG00000162692
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vcam1bENSDARG00000062479Danio rerio
 VCAM1ENSGALG00000005257Gallus gallus
 Vcam1ENSMUSG00000027962Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9BZZ2 / SIGLEC1 / sialic acid binding Ig like lectin 1ENSG0000008882719
CD22 / P20273 / CD22 moleculeENSG0000001212417


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR003987  Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal
 IPR003989  Vascular cell adhesion molecule-1
 IPR007110  Immunoglobulin-like domain
 IPR008424  Immunoglobulin C2-set
 IPR013098  Immunoglobulin I-set
 IPR013106  Immunoglobulin V-set domain
 IPR013151  Immunoglobulin
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0002526 acute inflammatory response IEA
 biological_processGO:0002544 chronic inflammatory response IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IDA
 biological_processGO:0007159 leukocyte cell-cell adhesion IDA
 biological_processGO:0007160 cell-matrix adhesion IDA
 biological_processGO:0007568 aging IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0009308 amine metabolic process IDA
 biological_processGO:0010043 response to zinc ion IEA
 biological_processGO:0010212 response to ionizing radiation IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0022614 membrane to membrane docking IEP
 biological_processGO:0030183 B cell differentiation IC
 biological_processGO:0030198 extracellular matrix organization TAS
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0035094 response to nicotine IEA
 biological_processGO:0035584 calcium-mediated signaling using intracellular calcium source IGI
 biological_processGO:0035924 cellular response to vascular endothelial growth factor stimulus IEA
 biological_processGO:0042102 positive regulation of T cell proliferation IDA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0050776 regulation of immune response TAS
 biological_processGO:0050901 leukocyte tethering or rolling IDA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060326 cell chemotaxis IEA
 biological_processGO:0060333 interferon-gamma-mediated signaling pathway TAS
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0098609 cell-cell adhesion IEA
 cellular_componentGO:0002102 podosome IDA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005769 early endosome IDA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005902 microvillus IDA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030175 filopodium IDA
 cellular_componentGO:0042383 sarcolemma IEA
 cellular_componentGO:0045177 apical part of cell IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0071065 alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex IDA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008131 primary amine oxidase activity IDA
 molecular_functionGO:0050839 cell adhesion molecule binding IPI


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Integrin cell surface interactions
Interleukin-4 and Interleukin-13 signaling
Interferon gamma signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000144668 ITGA9 / Q13797 / integrin subunit alpha 9  / reaction / complex
 ENSG00000115232 ITGA4 / P13612 / integrin subunit alpha 4  / reaction / complex
 ENSG00000150093 ITGB1 / P05556 / integrin subunit beta 1  / reaction / complex






 

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