ENSMUSG00000027962


Mus musculus

Features
Gene ID: ENSMUSG00000027962
  
Biological name :Vcam1
  
Synonyms : P29533 / vascular cell adhesion molecule 1 / Vcam1
  
Possible biological names infered from orthology : P19320
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: G1
Gene start: 116109949
Gene end: 116129688
  
Corresponding Affymetrix probe sets: 10501608 (MoGene1.0st)   1415989_at (Mouse Genome 430 2.0 Array)   1436003_at (Mouse Genome 430 2.0 Array)   1448162_at (Mouse Genome 430 2.0 Array)   1451314_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000143260
Ensembl peptide - ENSMUSP00000029574
Ensembl peptide - ENSMUSP00000142876
NCBI entrez gene - 22329     See in Manteia.
MGI - MGI:98926
RefSeq - NM_011693
RefSeq Peptide - NP_035823
swissprot - A0A0G2JFP9
swissprot - P29533
swissprot - Q3UPN1
swissprot - Q544V4
Ensembl - ENSMUSG00000027962
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vcam1bENSDARG00000062479Danio rerio
 VCAM1ENSGALG00000005257Gallus gallus
 VCAM1ENSG00000162692Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Siglec1 / sialic acid binding Ig-like lectin 1, sialoadhesin / Q9BZZ2* / sialic acid binding Ig like lectin 1*ENSMUSG0000002732219
Cd22 / CD22 molecule / P20273*ENSMUSG0000003057717


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR003987  Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal
 IPR003989  Vascular cell adhesion molecule-1
 IPR007110  Immunoglobulin-like domain
 IPR008424  Immunoglobulin C2-set
 IPR013098  Immunoglobulin I-set
 IPR013151  Immunoglobulin
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0002526 acute inflammatory response IEA
 biological_processGO:0002544 chronic inflammatory response IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISO
 biological_processGO:0007159 leukocyte cell-cell adhesion ISO
 biological_processGO:0007160 cell-matrix adhesion ISO
 biological_processGO:0007507 heart development IMP
 biological_processGO:0007568 aging IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0009308 amine metabolic process ISO
 biological_processGO:0010043 response to zinc ion IEA
 biological_processGO:0010212 response to ionizing radiation IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0022614 membrane to membrane docking IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0035094 response to nicotine IEA
 biological_processGO:0035584 calcium-mediated signaling using intracellular calcium source ISO
 biological_processGO:0035924 cellular response to vascular endothelial growth factor stimulus IEA
 biological_processGO:0042102 positive regulation of T cell proliferation ISO
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0050901 leukocyte tethering or rolling ISO
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060326 cell chemotaxis IEA
 biological_processGO:0060669 embryonic placenta morphogenesis IMP
 biological_processGO:0060710 chorio-allantoic fusion IMP
 biological_processGO:0061032 visceral serous pericardium development TAS
 biological_processGO:0071333 cellular response to glucose stimulus IDA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0098609 cell-cell adhesion IEA
 cellular_componentGO:0002102 podosome ISO
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0005769 early endosome ISO
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005902 microvillus ISO
 cellular_componentGO:0009897 external side of plasma membrane ISO
 cellular_componentGO:0009986 cell surface ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030175 filopodium ISO
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0042383 sarcolemma IEA
 cellular_componentGO:0045177 apical part of cell ISO
 cellular_componentGO:0071065 alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex ISO
 cellular_componentGO:0071944 cell periphery IDA
 molecular_functionGO:0005178 integrin binding ISO
 molecular_functionGO:0008131 primary amine oxidase activity ISO
 molecular_functionGO:0050839 cell adhesion molecule binding ISO


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Integrin cell surface interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Vcam1tm1Dmil/Vcam1tm1Dmil
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr,Ldlrtm1Her/Ldlrtm1Her,Vcam1tm1Dmil/Vcam1tm1Dmil
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Vcam1tm2Flv/Vcam1tm3Flv,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S1/Sv * C3H * C57BL/6

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr,Ldlrtm1Her/Ldlrtm1Her,Vcam1tm1Dmil/Vcam1tm1Dmil
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ckmt2tm1Bew/Ckmt2tm1Bew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Vcam1tm1Dmil/Vcam1tm1Dmil
Genetic Background: C.129S4-Vcam1tm1Dmil

Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr,Ldlrtm1Her/Ldlrtm1Her,Vcam1tm1Dmil/Vcam1tm1Dmil
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Otx1tm1Asim/Otx1tm1Asim
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Vcam1tm2Flv/Vcam1tm2Flv,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Vcam1tm2Flv/Vcam1tm3Flv,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S1/Sv * C3H * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Otx1tm1Asim/Otx1tm1Asim
Genetic Background: involves: 129P2/OlaHsd

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0001726 abnormal allantois "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ogttm1Gwh/Ogttm1Gwh,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ogttm1Gwh/Ogttm1Gwh,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0002127 abnormal cardiovascular system morphology "abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0002190 disorganized myocardium "malformed or poorly developed cardiac muscle layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67044]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Otx1tm1Asim/Otx1tm1Asim
Genetic Background: involves: 129P2/OlaHsd

 MP:0002429 abnormal blood cell morphology/development "anomalous structure, differentiation, or number of any of the cells found in the blood" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Otx1tm1Asim/Otx1tm1Asim
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Vcam1tm2Flv/Vcam1tm2Flv,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Otx1tm1Asim/Otx1tm1Asim
Genetic Background: involves: 129P2/OlaHsd

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0002824 abnormal chorioallantoic fusion "abnormal process of or failure of the formation of the membrane that forms the fetal portion of the placenta; derived from the fusion of the chorion and the allantois" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

Allelic Composition: Vcam1tm1Dmil/Vcam1tm1Dmil
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Vcam1tm1Dmil/Vcam1tm1Dmil
Genetic Background: C.129S4-Vcam1tm1Dmil

Allelic Composition: Vcam1tm1Dmil/Vcam1tm1Dmil
Genetic Background: either: B6.129S4-Vcam1tm1Dmil or (involves: 129S4/SvJae)

 MP:0003057 abnormal epicardium morphology "anomalous structure of the visceral layer of the pericardium that surrounds and attaches to all the surfaces of the heart" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0003799 impaired macrophage migration "defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr,Vcam1tm1Dmil/Vcam1tm1Dmil
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003945 abnormal lymphocyte physiology "abnormal function of any of the white blood cells that includes B cells, T cells, and NK cells " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Vcam1tm2Flv/Vcam1tm3Flv,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S1/Sv * C3H * C57BL/6

 MP:0004057 thin myocardial compact layer "reduced thickness of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0004392 abnormal CD8-positive T cell physiology "abnormal function of the subset of T lymphocytes that express the CD8 marker on the cell surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vcam1tm2Flv/Vcam1tm3Flv,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S1/Sv * C3H * C57BL/6

 MP:0004557 dilated allantois "an expansion in the volume of the fetal membrane which contributes to the formation of the umbilical cord and placental blood vessels, as by stretching or distention" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr,Ldlrtm1Her/Ldlrtm1Her,Vcam1tm1Dmil/Vcam1tm1Dmil
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vcam1tm1Dmil/Vcam1tm1Dmil
Genetic Background: C.129S4-Vcam1tm1Dmil

Allelic Composition: Vcam1tm2Roml/Vcam1tm2Roml,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vcam1tm1Dmil/Vcam1tm1Dmil
Genetic Background: C.129S4-Vcam1tm1Dmil

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ogttm1Gwh/Ogttm1Gwh,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Vcam1tm2Flv/Vcam1tm3Flv,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S1/Sv * C3H * C57BL/6

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr,Ldlrtm1Her/Ldlrtm1Her,Vcam1tm1Dmil/Vcam1tm1Dmil
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0005341 decreased susceptibility to atherosclerosis "less likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Vcam1tm1Dmil/Vcam1tm1Dmil
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr,Ldlrtm1Her/Ldlrtm1Her,Vcam1tm1Dmil/Vcam1tm1Dmil
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vcam1tm2Flv/Vcam1tm3Flv,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S1/Sv * C3H * C57BL/6

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vcam1tm2Flv/Vcam1tm3Flv,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S1/Sv * C3H * C57BL/6

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vcam1tm2Flv/Vcam1tm3Flv,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S1/Sv * C3H * C57BL/6

 MP:0008189 increased transitional stage B cell number "greater number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vcam1tm2Roml/Vcam1tm2Roml,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0008190 decreased transitional stage B cell number "reduced number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vcam1tm2Roml/Vcam1tm2Roml,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0008210 increased mature B cell number "greater number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Vcam1tm2Roml/Vcam1tm2Roml,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Vcam1tm2Roml/Vcam1tm2Roml,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0008214 increased immature B cell number "greater number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vcam1tm2Roml/Vcam1tm2Roml,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Vcam1tm2Flv/Vcam1tm3Flv,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S1/Sv * C3H * C57BL/6

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vcam1tm2Flv/Vcam1tm3Flv,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S1/Sv * C3H * C57BL/6

 MP:0008826 abnormal splenic cell ratio "deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Vcam1tm2Flv/Vcam1tm3Flv,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S1/Sv * C3H * C57BL/6

 MP:0009657 failure of chorioallantoic fusion "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Ogttm1Gwh/Ogttm1Gwh,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Vcam1tm1Dmil/Vcam1tm1Dmil
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Vcam1tm1Dmil/Vcam1tm1Dmil
Genetic Background: C.129S4-Vcam1tm1Dmil

Allelic Composition: Vcam1tm1Dmil/Vcam1tm1Dmil
Genetic Background: either: B6.129S4-Vcam1tm1Dmil or (involves: 129S4/SvJae)

 MP:0011825 decreased cell chemotaxis "reduciton in the directed movement response of a motile cell guided by a specific chemical concentration gradient; movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)" [MGI:csmith]
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Allelic Composition: Vcam1tm1Dmil/Vcam1tm1Dmil
Genetic Background: C.129S4-Vcam1tm1Dmil

Allelic Composition: Vcam1tm2Dmil/Vcam1tm2Dmil
Genetic Background: B6.129S4-Vcam1tm2Dmil

Allelic Composition: Vcam1tm1Dmil/Vcam1tm1Dmil
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr,Vcam1tm1Dmil/Vcam1tm1Dmil
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr,Vcam1tm1Dmil/Vcam1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0012299 hydropic allantois "excessive accumulation of fluid within the allantoic sac" [MGI:anna]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000039115 Itga9 / B8JK39 / Integrin alpha-9 / Q13797* / integrin subunit alpha 9*  / reaction / complex
 ENSMUSG00000027009 Itga4 / integrin subunit alpha 4 / P13612*  / complex / reaction
 ENSMUSG00000025809 Itgb1 / P09055 / Integrin beta-1 / P05556* / integrin subunit beta 1*  / complex / reaction






 

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