Manteia - Molecule gene

ENSMUSG00000030577

Mus musculus

Features

Gene ID:	ENSMUSG00000030577

Biological name :	Cd22

Synonyms :	Cd22 / CD22 molecule

Possible biological names infered from orthology :	P20273

Species:	Mus musculus

Chr. number:	7
Strand:	-1
Band:	B1
Gene start:	30865402
Gene end:	30880342

Corresponding Affymetrix probe sets:	10562132 (MoGene1.0st) 1419768_at (Mouse Genome 430 2.0 Array) 1419769_at (Mouse Genome 430 2.0 Array) 1445222_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000140014 Ensembl peptide - ENSMUSP00000150025 Ensembl peptide - ENSMUSP00000141178 Ensembl peptide - ENSMUSP00000140528 Ensembl peptide - ENSMUSP00000140521 Ensembl peptide - ENSMUSP00000140450 Ensembl peptide - ENSMUSP00000140357 Ensembl peptide - ENSMUSP00000019248 Ensembl peptide - ENSMUSP00000103760 Ensembl peptide - ENSMUSP00000139685 Ensembl peptide - ENSMUSP00000139871 NCBI entrez gene - 12483 See in Manteia. MGI - MGI:88322 RefSeq - XM_006539489 RefSeq - XM_006539494 RefSeq - XM_006539493 RefSeq - XM_006539492 RefSeq - XM_006539491 RefSeq - NM_001043317 RefSeq - NM_009845 RefSeq - XM_006539495 RefSeq - XM_006539490 RefSeq Peptide - NP_001036782 RefSeq Peptide - NP_033975 swissprot - Q3UP36 swissprot - A0A1L1SSS3 swissprot - A0A087WQ27 swissprot - A0A087WQV3 swissprot - A0A087WR31 swissprot - A0A087WR96 swissprot - A0A087WST4 Ensembl - ENSMUSG00000030577

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
BX927068.2	ENSDARG00000096621	Danio rerio
cd22	ENSDARG00000053005	Danio rerio
si:ch211-152f2.1	ENSDARG00000092322	Danio rerio
si:ch211-152f2.2	ENSDARG00000034910	Danio rerio
si:ch211-152f2.3	ENSDARG00000043445	Danio rerio
si:ch211-152f2.4	ENSDARG00000096574	Danio rerio
si:ch211-1f22.10	ENSDARG00000096619	Danio rerio
si:ch211-1f22.11	ENSDARG00000094524	Danio rerio
si:ch211-1f22.12	ENSDARG00000093845	Danio rerio
si:ch211-1f22.13	ENSDARG00000096623	Danio rerio
si:ch211-1f22.14	ENSDARG00000062309	Danio rerio
si:ch211-1f22.16	ENSDARG00000096670	Danio rerio
si:ch211-1f22.3	ENSDARG00000101532	Danio rerio
si:ch211-1f22.5	ENSDARG00000054655	Danio rerio
si:ch211-1f22.6	ENSDARG00000096656	Danio rerio
si:ch211-1f22.7	ENSDARG00000096543	Danio rerio
si:ch211-1f22.8	ENSDARG00000096507	Danio rerio
si:ch211-1f22.9	ENSDARG00000096585	Danio rerio
si:ch73-94k4.1	ENSDARG00000096634	Danio rerio
si:ch73-94k4.3	ENSDARG00000096671	Danio rerio
si:ch73-94k4.5	ENSDARG00000096523	Danio rerio
si:dkey-24p1.1	ENSDARG00000039096	Danio rerio
si:dkey-27j5.10	ENSDARG00000094157	Danio rerio
si:dkey-27j5.11	ENSDARG00000096650	Danio rerio
si:dkey-27j5.6	ENSDARG00000086301	Danio rerio
si:dkey-27j5.7	ENSDARG00000096570	Danio rerio
si:dkey-27j5.8	ENSDARG00000096534	Danio rerio
si:dkey-33i11.1	ENSDARG00000053027	Danio rerio
zgc:171470	ENSDARG00000057844	Danio rerio
zmp:0000001289	ENSDARG00000089894	Danio rerio
CD22	ENSG00000012124	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Siglec1 / sialic acid binding Ig-like lectin 1, sialoadhesin / Q9BZZ2* / sialic acid binding Ig like lectin 1*	ENSMUSG00000027322	23
Vcam1 / P29533 / vascular cell adhesion molecule 1 / P19320*	ENSMUSG00000027962	15

Protein motifs (from Interpro)

Interpro ID	Name
IPR003598	Immunoglobulin subtype 2
IPR003599	Immunoglobulin subtype
IPR007110	Immunoglobulin-like domain
IPR013162	CD80-like, immunoglobulin C2-set
IPR013783	Immunoglobulin-like fold
IPR036179	Immunoglobulin-like domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA

Pathways (from Reactome)

Pathway description

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

CD22 mediated BCR regulation

Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000685	abnormal immune system morphology	"morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cd22^tm3Lnit/Cd22^tm3Lnit Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0001790	abnormal immune system physiology	"deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Itk^tm1Ljb/Itk^tm1Ljb Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Cd22^tm3Lnit/Cd22^tm3Lnit Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0001800	abnormal humoral immune response	"abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Ar^tm1Verh/Y,Pten^tm1Hwu/Pten^tm1Hwu,Tg(Pbsn-cre)4Prb/0 Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * DBA/2
MP:0001802	arrested B cell development	"inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]	Show Allelic Composition: Tnfsf13b^m1Anu/Tnfsf13b^m1Anu Genetic Background: C57BL/6JAnu-Tnfsf13b^m1Anu/Apb
MP:0001806	decreased IgM	"less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ucp1^tm1Kz/Ucp1^tm1Kz,Ucp3^tm1Rei/Ucp3^tm1Rei Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss Allelic Composition: Cd22^m1Btlr/Cd22^m1Btlr Genetic Background: involves: C57BL/6J
MP:0001844	autoimmune response	"condition in which cells and/or antibodies arise from and are directed against one s own tissues " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cd22^tm1Lnit/Cd22^tm1Lnit Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Cd22^tm3Lnit/Cd22^tm3Lnit Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Itk^tm1Ljb/Itk^tm1Ljb Genetic Background: involves: 129 * C57BL/6
MP:0002144	abnormal B lymphocyte development	"atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ar^tm1Verh/Y,Pten^tm1Hwu/Pten^tm1Hwu,Tg(Pbsn-cre)4Prb/0 Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * DBA/2 Allelic Composition: Cd22^m1Btlr/Cd22^m1Btlr Genetic Background: involves: C57BL/6J Allelic Composition: Cd22^m2Btlr/Cd22^m2Btlr Genetic Background: C57BL/6J-Cd22^m2Btlr
MP:0002459	abnormal B cell physiology	"abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Itk^tm1Ljb/Itk^tm1Ljb Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Cd22^{tm1.1(CD22)Lnit}/Cd22^{tm1.1(CD22)Lnit} Genetic Background: involves: 129S4/SvJae Allelic Composition: Cd22^tm3Lnit/Cd22^tm3Lnit Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0002490	abnormal circulating immunoglobulin concentration	"deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Itk^tm1Ljb/Itk^tm1Ljb Genetic Background: involves: 129 * C57BL/6
MP:0002493	increased IgG	"greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Itk^tm1Ljb/Itk^tm1Ljb Genetic Background: involves: 129 * C57BL/6
MP:0002494	increased IgM	"greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cd22^tm1Eac/Cd22⁺,Lyn^tm1Ard/Lyn⁺,Ptpn6^me-v/Ptpn6⁺,Tg(IghelMD4)4Ccg/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Cd22^tm1Msn/Cd22^tm1Msn Genetic Background: either: (involves: 129S/SvEv * BALB/c) or (involves: 129S/SvEv * C57BL/6J)
MP:0004762	increased anti-double stranded DNA antibody level	"increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd22^tm1Msn/Cd22^tm1Msn Genetic Background: either: (involves: 129S/SvEv * BALB/c) or (involves: 129S/SvEv * C57BL/6J)
MP:0004816	abnormal class switch recombination	"anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tg(Tcra51-11.5,Tcrb51-11.5)AR206Ayr/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6NTac * DBA/2
MP:0004944	abnormal B cell negative selection	"any anomaly in the process through which B cells which react strongly with self-antigens are eliminated, usually through anergy or deletion" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd22^tm1Eac/Cd22⁺,Lyn^tm1Ard/Lyn⁺,Ptpn6^me-v/Ptpn6⁺,Tg(IghelMD4)4Ccg/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Cd22^tm1Eac/Cd22⁺,Ptpn6^me-v/Ptpn6⁺,Tg(IghelMD4)4Ccg/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Cd22^tm1Eac/Cd22⁺,Lyn^tm1Ard/Lyn⁺,Tg(IghelMD4)4Ccg/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004977	increased B-1 B cell number	"greater number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd22^tm1Msn/Cd22^tm1Msn Genetic Background: either: (involves: 129S/SvEv * BALB/c) or (involves: 129S/SvEv * C57BL/6J)
MP:0005017	decreased B cell number	"fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tnfrsf13c^tm1Mass/Tnfrsf13c^tm1Mass Genetic Background: C57BL/6-Tnfrsf13c^tm1Mass Allelic Composition: Cd22^tm3Tft/Cd22^tm3Tft Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Cd22^tm1Tft/Cd22^tm1Tft Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Cd22^m1Anu/Cd22^m1Anu Genetic Background: C57BL/6JAnu-Cd22^m1Anu/Apb Allelic Composition: Cd22^{tm1.1(CD22)Lnit}/Cd22^{tm1.1(CD22)Lnit} Genetic Background: involves: 129S4/SvJae Allelic Composition: Cd22^tm3Lnit/Cd22^tm3Lnit Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 Allelic Composition: Cd22^tm2Tft/Cd22^tm2Tft Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Cd22^m3Btlr/Cd22^m3Btlr Genetic Background: C57BL/6J-Cd22^m3Btlr Allelic Composition: Cd22^m4Btlr/Cd22^m4Btlr Genetic Background: C57BL/6J-Cd22^m4Btlr Allelic Composition: Cd22^m5Btlr/Cd22^m5Btlr Genetic Background: C57BL/6J-Cd22^m5Btlr
MP:0005093	impaired B cell proliferation	"absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tnfrsf13c^tm1Mass/Tnfrsf13c^tm1Mass Genetic Background: C57BL/6-Tnfrsf13c^tm1Mass Allelic Composition: Cd22^tm3Tft/Cd22^tm3Tft Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Cd22^tm2Tft/Cd22^tm2Tft Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0005153	abnormal B cell proliferation	"change from the norm in the ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ucp1^tm1Kz/Ucp1^tm1Kz,Ucp3^tm1Rei/Ucp3^tm1Rei Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss
MP:0005154	increased B cell proliferation	"greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tnfrsf13c^tm1Mass/Tnfrsf13c^tm1Mass Genetic Background: C57BL/6-Tnfrsf13c^tm1Mass Allelic Composition: Cd22^tm3Tft/Cd22^tm3Tft Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Cd22^tm1Tft/Cd22^tm1Tft Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0005463	abnormal CD4+ T cell physiology	"anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cd22^m2Btlr/Cd22^m2Btlr Genetic Background: C57BL/6J-Cd22^m2Btlr
MP:0008167	increased B-1a cell number	"greater number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]	Show Allelic Composition: Cd22^m3Btlr/Cd22^m3Btlr Genetic Background: C57BL/6J-Cd22^m3Btlr Allelic Composition: Cd22^m4Btlr/Cd22^m4Btlr Genetic Background: C57BL/6J-Cd22^m4Btlr
MP:0008168	decreased B-1a cell number	"reduced number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]	Show Allelic Composition: Cd22^tm1Lam/Cd22^tm1Lam Genetic Background: involves: 129 * C57BL/6
MP:0008171	abnormal mature B cell morphology	"any structural anomaly of the mature form of a B cell, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ucp1^tm1Kz/Ucp1^tm1Kz,Ucp3^tm1Rei/Ucp3^tm1Rei Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss Allelic Composition: Cd22^tm1Eac/Cd22⁺,Tg(IghelMD4)4Ccg/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Cd22^tm1Eac/Cd22⁺,Lyn^tm1Ard/Lyn⁺,Ptpn6^me-v/Ptpn6⁺,Tg(IghelMD4)4Ccg/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Cd22^tm1Eac/Cd22⁺,Ptpn6^me-v/Ptpn6⁺,Tg(IghelMD4)4Ccg/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Cd22^tm1Eac/Cd22⁺,Lyn^tm1Ard/Lyn⁺,Tg(IghelMD4)4Ccg/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Cd22^tm1Msn/Cd22^tm1Msn Genetic Background: either: (involves: 129S/SvEv * BALB/c) or (involves: 129S/SvEv * C57BL/6J)
MP:0008182	decreased marginal zone B cell number	"reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]	Show Allelic Composition: Cd22^tm1Tft/Cd22^tm1Tft Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Cd22^tm1Lam/Cd22^tm1Lam Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Cd22^tm1Eac/Cd22^tm1Eac Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Cd22^{tm1.1(CD22)Lnit}/Cd22^{tm1.1(CD22)Lnit} Genetic Background: involves: 129S4/SvJae Allelic Composition: Cd22^tm1Lnit/Cd22^tm1Lnit Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Cd22^tm2Lnit/Cd22^tm2Lnit Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Cd22^tm3Lnit/Cd22^tm3Lnit Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0008188	abnormal transitional stage B cell morphology	"any structural anomaly of an immature B cell of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd22^tm1Eac/Cd22^tm1Eac Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008190	decreased transitional stage B cell number	"reduced number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd22^tm3Lnit/Cd22^tm3Lnit Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0008207	decreased B-2 cell number	"reduced number of conventional B cells subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells" [CL:0000822, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:11861604]	Show Allelic Composition: Cd22^m4Btlr/Cd22^m4Btlr Genetic Background: C57BL/6J-Cd22^m4Btlr
MP:0008211	decreased mature B cell number	"reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]	Show Allelic Composition: Cd22^tm1Tft/Cd22^tm1Tft Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Cd22^tm1Lam/Cd22^tm1Lam Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Cd22^tm1Eac/Cd22^tm1Eac Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008212	absent mature B cells	"absence of the mature form of a B cell, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd22^tm2Lnit/Cd22^tm2Lnit Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Cd22^tm3Lnit/Cd22^tm3Lnit Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0008217	abnormal B cell activation	"any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific" [GO:0002312, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd22^tm1Lam/Cd22^tm1Lam Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Cd22^tm1Lam/Cd22^tm1Lam,Igh^tm1.2Rsky/Igh^tm1.2Rsky Genetic Background: involves: 129 * BALB/c * C57BL/6 Allelic Composition: Cd22^tm1Eac/Cd22^tm1Eac Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Cd22^tm1Msn/Cd22^tm1Msn Genetic Background: either: (involves: 129S/SvEv * BALB/c) or (involves: 129S/SvEv * C57BL/6J)
MP:0008495	decreased IgG1 level	"less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd22^tm1Eac/Cd22^tm1Eac Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008498	decreased IgG3 level	"less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd22^tm1Eac/Cd22^tm1Eac Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008499	increased IgG1 level	"greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd22^tm3Lnit/Cd22^tm3Lnit Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0008500	increased IgG2a level	"greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd22^tm1Msn/Cd22^tm1Msn Genetic Background: either: (involves: 129S/SvEv * BALB/c) or (involves: 129S/SvEv * C57BL/6J)
MP:0008729	decreased memory B cell number	"reduced number of distinctly differentiated long-lived B cells that are readily activated upon reencounter of an antigenic determinant; memory B cells differentiate from antigen-activated B cells which have been selected for expression of higher affinity immunoglobulin" [CL:0000787, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd22^tm1Eac/Cd22^tm1Eac Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Cd22^m4Btlr/Cd22^m4Btlr Genetic Background: C57BL/6J-Cd22^m4Btlr
MP:0008746	abnormal peripheral B cell anergy	"any anomaly of the processes of B cell anergy that occur outside the bone marrow" [GO:0002453]	Show Allelic Composition: Cd22^tm2Tft/Cd22^tm2Tft Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0008782	increased B cell apoptosis	"increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd22^tm1Eac/Cd22^tm1Eac Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Cd22^tm3Lnit/Cd22^tm3Lnit Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0009923	decreased transitional stage T1 B cell number	"reduced number of a type of transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen; this cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative" [PMID:12810111]	Show Allelic Composition: Cd22^{tm1.1(CD22)Lnit}/Cd22^{tm1.1(CD22)Lnit} Genetic Background: involves: 129S4/SvJae
MP:0009926	decreased transitional stage T2 B cell number	"reduced number of a type of transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, and is located in the splenic B follicles" [PMID:12810111]	Show Allelic Composition: Cd22^{tm1.1(CD22)Lnit}/Cd22^{tm1.1(CD22)Lnit} Genetic Background: involves: 129S4/SvJae
MP:0010168	increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number	"a greater number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]	Show Allelic Composition: Cd22^m5Btlr/Cd22^m5Btlr Genetic Background: C57BL/6J-Cd22^m5Btlr
MP:0010674	increased activation-induced B cell apoptosis	"increased frequency of B cell apoptosis that occurs upon engagement of either the B cell receptor or CD40, but not both; the engagement leads to expression of fas or related receptors that make the B cell susceptible to fas-ligand mediated death" [PMID:11032170]	Show Allelic Composition: Cd22^tm2Tft/Cd22^tm2Tft Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0010838	increased CD8-positive, alpha-beta memory T cell number	"increased number of CD8-positive, alpha-beta T cells with memory phenotype indicated by being CD45RO and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high" [CL:0000909, GO_REF:0000031, GOC:tfm, PMID:20146720]	Show Allelic Composition: Cd22^m5Btlr/Cd22^m5Btlr Genetic Background: C57BL/6J-Cd22^m5Btlr
MP:0011805	decreased cell migration	"reduced or slower movement of cells from one site to another, often occuring during developmental or chemotactic processes" [GO:0016477, MGI:csmith]	Show Allelic Composition: Cd22^tm3Lnit/Cd22^tm3Lnit Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr